Organic Chemistry Research Paper Topics

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  • Carbon family
  • Fermentation
  • Hydrologic cycle
  • Natural gas
  • Nitrogen cycle
  • Nitrogen family
  • Oxygen family

In 1828, German chemist Friedrich Wöhler (1800–1882) proved that this theory of vitalism was untrue. He found a very simple way to convert chemical compounds from living organisms into comparable compounds from nonliving entities.

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As a result of Wöhler’s research, the definition of organic chemistry changed. The new definition was based on the observation that every compound discovered in living organisms had one property in common: they all contained the element carbon. As a result, the modern definition of organic chemistry—as the study of carbon compounds—was adopted.

Organic and Inorganic Chemistry

One important point that Wöhler’s research showed was that the principles and techniques of chemistry apply equally well to compounds found in living organisms and in nonliving things. Nonetheless, some important differences between organic and inorganic (not organic) compounds exist. These include the following:

  • The number of organic compounds vastly exceeds the number of inorganic compounds. The ratio of carbon-based compounds to noncarbon- based compounds is at least ten to one, with close to 10 million organic compounds known today. The reason for this dramatic difference is a special property of the carbon atom: its ability to join with other carbon atoms in very long chains, in rings, and in other kinds of geometric arrangements. It is not at all unusual for dozens, hundreds, or thousands of carbon atoms to bond to each other within a single compound—a property that no other element exhibits.
  • In general, organic compounds tend to have much lower melting and boiling points than do inorganic compounds.
  • In general, organic compounds are less likely to dissolve in water than are inorganic compounds.
  • Organic compounds are likely to be more flammable but poorer conductors of heat and electricity than are inorganic compounds.
  • Organic reactions tend to take place more slowly and to produce a much more complex set of products than do inorganic reactions.

Functional Groups and Organic Families

The huge number of organic compounds requires that some system be developed for organizing them. The criterion on which those compounds are organized is the presence of various functional groups. A functional group is an arrangement of atoms that is responsible for certain characteristic physical and chemical properties in a compound. For example, one such functional group is the hydroxyl group, consisting of an oxygen atom and hydrogen atom joined to each other. It is represented by the formula -OH.

All organic compounds with the same functional group are said to belong to the same organic family. Any organic compound that contains a hydroxyl group, for instance, is called an alcohol. All alcohols are similar to each other in that: (1) they contain one or more hydroxyl groups, and (2) because of those groups, they have similar physical and chemical properties. For example, alcohols tend to be more soluble in water than other organic compounds because the hydroxyl groups in the alcohol form bonds with water molecules.

The simplest organic compounds are the hydrocarbons, compounds that contain only two elements: carbon and hydrogen. The class of hydrocarbons can be divided into subgroups depending on the way in which carbon and hydrogen atoms are joined to each other. In some hydrocarbons, for example, carbon and hydrogen atoms are joined to each other only by single bonds. A single bond is a chemical bond that consists of a pair of electrons. Such hydrocarbons are known as saturated hydrocarbons.

In other hydrocarbons, carbon and hydrogen atoms are joined to each other by double or triple bonds. A double bond consists of two pairs of electrons, and a triple bond consists of three pairs of electrons. Hydrocarbons containing double and triple bonds are said to be unsaturated.

Hydrocarbons can also be open-chain or ring compounds. In an open-chain hydrocarbon, the carbon atoms are all arranged in a straight line, like a strand of spaghetti. In a ring hydrocarbon, the carbons are arranged in a continuous loop, such as a square, a pentagon, or a triangle.

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research paper topics in organic chemistry pdf

research paper topics in organic chemistry pdf

Themed collection Most popular 2022 organic chemistry articles

Open Access

Umpolung strategies for the functionalization of peptides and proteins

This perspective highlights the growing body of literature that leverages polarity reversal (umpolung reactivity) for the selective modification of proteinogenic functionalities and identifies opportunities for further innovation.

Graphical abstract: Umpolung strategies for the functionalization of peptides and proteins

Photocatalytic C(sp 3 ) radical generation via C–H, C–C, and C–X bond cleavage

C(sp 3 ) radicals (R˙) are of broad research interest and synthetic utility.

Graphical abstract: Photocatalytic C(sp3) radical generation via C–H, C–C, and C–X bond cleavage

H-bond cooperativity: polarisation effects on secondary amides

Formation of an intramolecular phenol-amide H-bond leads to a dramatic increase in the H-bond donor strength of the amide NH group. Polarisation of the amide group is directly proportional to the polarity of the phenol H-bond donor.

Graphical abstract: H-bond cooperativity: polarisation effects on secondary amides

Fast relaxing red and near-IR switchable azobenzenes with chalcogen and halogen substituents: periodic trends, tuneable thermal half-lives and chalcogen bonding

The synthesis of red-shifted azobenzenes functionalised with heavy chalcogen and halogen substituents is reported, enabling photo-switching with red and near IR light and Z → E thermal isomerization rates spanning seven orders of magnitude.

Graphical abstract: Fast relaxing red and near-IR switchable azobenzenes with chalcogen and halogen substituents: periodic trends, tuneable thermal half-lives and chalcogen bonding

BQ-AurIPr: a redox-active anticancer Au( I ) complex that induces immunogenic cell death

A redox-active anticancer Au( I ) complex that induces immunogenic cell death in non-small cell lung cancer cells has been identified. Mitochondrial oxidative stress leading to mitophagy-dependent secretion of various DAMPs is implicated as the main mechanism inducing ICD.

Graphical abstract: BQ-AurIPr: a redox-active anticancer Au(i) complex that induces immunogenic cell death

Discovery of novel drug-like antitubercular hits targeting the MEP pathway enzyme DXPS by strategic application of ligand-based virtual screening

We identified two drug-like antitubercular hits with submicromolar inhibition constants against the target 1-deoxy- D -xylulose-5-phosphate synthase (DXPS) with a new mode of action and promising activity against drug-resistant tuberculosis.

Graphical abstract: Discovery of novel drug-like antitubercular hits targeting the MEP pathway enzyme DXPS by strategic application of ligand-based virtual screening

Highly contorted superhelicene hits near-infrared circularly polarized luminescence

This twisted superhelicene employed its twists and loops to shine chiral emission into the NIR region. The proof of its promising applicability in optoelectronic devices is the analogous chiroptical properties obtained in solution and thin films.

Graphical abstract: Highly contorted superhelicene hits near-infrared circularly polarized luminescence

Ferroptosis promotes sonodynamic therapy: a platinum( II )–indocyanine sonosensitizer

A novel platinum( II )–cyanine complex showed a greater excellent sonodynamic therapeutic effect than photodynamic therapy in vivo . This work expands the biological applications of metal complexes from traditional photodynamic therapy to sonodynamic therapy.

Graphical abstract: Ferroptosis promotes sonodynamic therapy: a platinum(ii)–indocyanine sonosensitizer

Non-directed Pd-catalysed electrooxidative olefination of arenes

The Fujiwara–Moritani reaction using electric current is a powerful tool for the olefination of arenes by Pd-catalysed C–H activation.

Graphical abstract: Non-directed Pd-catalysed electrooxidative olefination of arenes

Subphthalocyanine capsules: molecular reactors for photoredox transformations of fullerenes

A photoredox cage built by coordination of two pyridyl-subphthalocyanines to Pd centers has proved versatile and efficient to catalyze photoredox addition reactions over encapsulated C 60 .

Graphical abstract: Subphthalocyanine capsules: molecular reactors for photoredox transformations of fullerenes

Iridium-catalyzed α-selective deuteration of alcohols

An α-selective, iridium( III )-bipyridonate-catalyzed hydrogen isotope exchange of alcohols using D 2 O has been developed for the direct, chemoselective deuteration of primary and secondary alcohols, thereby providing deuterated bioactive molecules.

Graphical abstract: Iridium-catalyzed α-selective deuteration of alcohols

Catalytic defluorinative ketyl–olefin coupling by halogen-atom transfer

A catalytic ketyl–olefin coupling reaction including sequentially orchestrated Lewis acid activation, halogen-atom transfer, radical addition, single-electron reduction and β-fluoro elimination has been developed.

Graphical abstract: Catalytic defluorinative ketyl–olefin coupling by halogen-atom transfer

Zn( II )-Coordination-driven self-assembled nanoagents for multimodal imaging-guided photothermal/gene synergistic therapy

siRNA@PT-ZIF-8 was prepared by one pot self-assembly for tri-mode imaging guided mild-temperature photothermal synergetic gene therapy.

Graphical abstract: Zn(ii)-Coordination-driven self-assembled nanoagents for multimodal imaging-guided photothermal/gene synergistic therapy

General electrochemical Minisci alkylation of N -heteroarenes with alkyl halides

Herein, we report, a general, facile and environmentally friendly Minisci-type alkylation of N -heteroarenes under simple and straightforward electrochemical conditions using widely available alkyl halides as radical precursors.

Graphical abstract: General electrochemical Minisci alkylation of N-heteroarenes with alkyl halides

Customising excitation properties of polycyclic aromatic hydrocarbons by rational positional heteroatom doping: the peri -xanthenoxanthene ( PXX ) case

In this paper we tackle the challenge of gaining control of the photophysical properties of PAHs through a site-specific N-doping within the structural aromatic framework.

Graphical abstract: Customising excitation properties of polycyclic aromatic hydrocarbons by rational positional heteroatom doping: the peri-xanthenoxanthene (PXX) case

A practical and sustainable two-component Minisci alkylation via photo-induced EDA-complex activation

An operationally simple, open-air, and efficient light-mediated Minisci C–H alkylation method is described, based on the formation of an electron donor–acceptor (EDA) complex between nitrogen-containing heterocycles and redox-active esters.

Graphical abstract: A practical and sustainable two-component Minisci alkylation via photo-induced EDA-complex activation

A sequential cyclization/π-extension strategy for modular construction of nanographenes enabled by stannole cycloadditions

Stannoles are introduced as a new, spontaneously aromatizing diene for [4 + 2] cycloadditions that can be easily introduced into diverse conjugated systems, facilitating the efficient synthesis of complex PAHs and their π-extension.

Graphical abstract: A sequential cyclization/π-extension strategy for modular construction of nanographenes enabled by stannole cycloadditions

Functional group divergence and the structural basis of acridine photocatalysis revealed by direct decarboxysulfonylation

Carboxylic acids can now serve as a single point of entry to several sulfonyl functional groups by a one-step organophotocatalytic sulfonylation, revealing structural effects that enable the photocatalysis.

Graphical abstract: Functional group divergence and the structural basis of acridine photocatalysis revealed by direct decarboxysulfonylation

An integrated platform approach enables discovery of potent, selective and ligand-competitive cyclic peptides targeting the GIP receptor

mRNA display generates vast datasets of protein binders. Bioinformatic clustering of the sequences combined with high throughput synthesis and analysis methods allow efficient prioritisation of hits for in vivo experiments.

Graphical abstract: An integrated platform approach enables discovery of potent, selective and ligand-competitive cyclic peptides targeting the GIP receptor

NHC and visible light-mediated photoredox co-catalyzed 1,4-sulfonylacylation of 1,3-enynes for tetrasubstituted allenyl ketones

Unprecedented NHC and photocatalysis co-catalyzed radical 1,4-sulfonylacylation of 1,3-enynes has been realized, providing structurally diversified tetrasubstituted allenyl ketones via allenyl and ketyl radical cross-coupling.

Graphical abstract: NHC and visible light-mediated photoredox co-catalyzed 1,4-sulfonylacylation of 1,3-enynes for tetrasubstituted allenyl ketones

Selective covalent targeting of SARS-CoV-2 main protease by enantiopure chlorofluoroacetamide

Chlorofluoroacetamide (CFA) was used as the warhead for covalent targeting of SARS-CoV-2 M pro . The chirality at CFA showed marked influence on inhibitory activity, suggesting stereospecific activation of CFA for cysteine modification in the protein.

Graphical abstract: Selective covalent targeting of SARS-CoV-2 main protease by enantiopure chlorofluoroacetamide

Electrooxidative palladium- and enantioselective rhodium-catalyzed [3 + 2] spiroannulations

Despite indisputable progress in the development of electrochemical transformations, electrocatalytic annulations for the synthesis of biologically relevant three-dimensional spirocyclic compounds has as of yet not been accomplished.

Graphical abstract: Electrooxidative palladium- and enantioselective rhodium-catalyzed [3 + 2] spiroannulations

Pressing matter: why are ionic liquids so viscous?

We use an experimental approach to compare an ionic liquid with a molecular mimic, focusing on viscosities. Charge network and coulombic compaction contribute significantly to the high viscosity of ionic liquids; we discuss the implications on their design and optimisation.

Graphical abstract: Pressing matter: why are ionic liquids so viscous?

Suzuki-type cross-coupling of alkyl trifluoroborates with acid fluoride enabled by NHC/photoredox dual catalysis

An acylative Suzuki-type cross-coupling of alkyl trifluoroborates and acid fluorides was developed by merging NHC organocatalysis with photoredox catalysis. A broad spectrum of ketones could be facilely synthesised under mild reaction conditions.

Graphical abstract: Suzuki-type cross-coupling of alkyl trifluoroborates with acid fluoride enabled by NHC/photoredox dual catalysis

Retaining the structural integrity of disulfide bonds in diphtheria toxoid carrier protein is crucial for the effectiveness of glycoconjugate vaccine candidates

The introduction of glycoconjugate vaccines marks an important point in the fight against various infectious diseases.

Graphical abstract: Retaining the structural integrity of disulfide bonds in diphtheria toxoid carrier protein is crucial for the effectiveness of glycoconjugate vaccine candidates

Prediction of protein p K a with representation learning

We developed new empirical ML model for protein p K a prediction with MAEs below 0.5 for all amino acid types.

Graphical abstract: Prediction of protein pKa with representation learning

Enhanced N-directed electrophilic C–H borylation generates BN–[5]- and [6]helicenes with improved photophysical properties

An enhanced N-directed electrophilic C–H borylation methodology has been developed that provides access to azaborine containing helicenes.

Graphical abstract: Enhanced N-directed electrophilic C–H borylation generates BN–[5]- and [6]helicenes with improved photophysical properties

About this collection

This specially curated collection pulls together some of the most popular articles from 2022 in the field of organic chemistry. The collection presents some outstanding contributions to the field, ranging from photocatalytic radical generation to prediction of protein pKa, and as with all Chemical Science articles – they are all completely free to access and read. We hope you enjoy browsing through this collection.

If a particular article has inspired you, do feel free to share on social media using the buttons on each article landing page and use our hashtag: #ChemSciMostPopular

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Organic chemistry articles within Scientific Reports

Article 31 March 2024 | Open Access

Design, synthesis and bioactivity study on oxygen-heterocyclic-based pyran analogues as effective P -glycoprotein-mediated multidrug resistance in MCF-7/ADR cell

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Sulfonated magnetic spirulina nanobiomaterial as a novel and environmentally friendly catalyst for the synthesis of dihydroquinazolin-4(1H)-ones in aqueous medium

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Article 26 January 2024 | Open Access

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Article 16 January 2024 | Open Access

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Palladium-based pseudohomogeneous catalyst for highly selective aerobic oxidation of benzylic alcohols to aldehydes

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Copper-catalyzed synthesis of pyrazolo[1,5- a ]pyrimidine based triazole-linked glycohybrids: mechanistic insights and bio-applications

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Department of chemistry: dissertations, theses, and student research.

Halide Exchange and Transport in Halide Perovskite Lattices , Temban Acha Billy

Synthesis and Study of High-Spin Stable Organic Radicals for Electrical Conductors and Mannosamine Nitroxide for MRI Contrast Agents , Shuyang Zhang

Designing Experiments: The Impact of Peer Review Structure on Organic Chemistry Students' Experimental Designs , Katie Patterson

Study of halide gradient formation via solution-solid halide exchange in crystalline CH 3 NH 3 PbBr 3 thin films , Behnaz Akbari

Oxygen Binding Thermodynamics of Human Hemoglobin in the Red Blood Cell , Kyle K. Hill

Developing Techniques for the Identification of Non-Canonical RNA Pairing and Analysis of LC-MS Datasets , Christopher Jurich

Surface Functionalization of Elastomers for Tunable Crystal Growth and Smart Adhesives , John Kapitan

Issue of False Amphetamine Field Test Positives Caused By Sugar. Use of Baeyer Test as a Secondary Test Solution. , Reed A. Knutson, Jennah Duncan, Kara Peightal, and Samuel Thomas

Harnessing Surface Chemistry and Instabilities in Silicone Elastomers to Synthesize Adaptive Systems with Mechanically Tunable Surface Properties and Functionality , Ali Jamal Mazaltarim

How Oxygen-Binding Affects Structural Evolution of Even-Sized Gold Anion Clusters. (Size Range 20 to 34) , David Brunken-Deibert

Analysis of Hydroxychloroquine Interaction with Serum Proteins by High Performance Affinity Chromatography , Kyungah Suh, Sadia Sharmeen, and David S. Hage

The Application and Development of Metabolomics Methodologies for the Profiling of Food and Cellular Toxicity , Jade Woods

Evaluation of the Overall Binding of Acetohexamide and Tolbutamide with Methyl Glyoxal-Modified HSA by High-Performance Affinity Chromatography , Ashley G. Woolfork and David S. Hage

C(sp2)-C(sp3) Cross-Coupling of Aryl Halides and Active C(sp3)-H Bonds via Dual Catalysis: Organic Photocatalysis/Nickel Redox Catalysis , Nicholas Armada

Phosphonate-Directed Catalytic Asymmetric Hydroboration: Synthesis of Functionalized Chiral Secondary and Tertiary Boronic Esters and Mechanistic Insights , Suman Chakrabarty

COMPUTATIONAL STUDIES OF THERMAL PROPERTIES AND DESALINATION PERFORMANCE OF LOW-DIMENSIONAL MATERIALS , Yang Hong

QUANTUM CHEMICAL CALCULATIONS APPLIED TO SOMO-HOMO CONVERSION AND VIBRATIONALLY AVERAGED NMR SHIELDING PARAMETERS , Erik Johnson

Design and Synthesis of Stable Aminyl and Nitroxide Radical Precursors , Joshua Bryan Lovell

Development of Nanomaterial Supports for the Study of Affinity-Based Analytes Using Ultra-Thin Layer Chromatography , Allegra Pekarek

ANALYSIS OF DRUG-PROTEIN INTERACTIONS DURING DIABETES BY HIGH-PERFORMANCE AFFINITY CHROMATOGRAPHY , Pingyang Tao

Electropolymerization and Characterization of Thin Film Dielectrics , Christopher White II

Synthesis, Characterization, and Catalytic Activity of Copper Palladium Oxide Solid Solutions. , Gregory L. Christensen

GLOBAL MINIMUM SEARCH AND CARBON MONOXIDE BINDING STUDIES OF NOVEL GOLD NANOCLUSTERS , Navneet S. Khetrapal

Mass Spectrometry and Nuclear Magnetic Resonance in the Chemometric Analysis of Cellular Metabolism , Eli Riekeberg

Ultrafast Affinity Extraction and High-Performance Affinity Chromatography Applications for Measuring Free Drug Fractions: Interactions of Sulfonylurea Drugs with Normal and Glycated Human Serum Albumin , Bao Yang

DEVELOPMENT OF ENTRAPMENT COLUMNS FOR THE STUDY OF AFFINITY BASED ANALYSIS OF DRUG-PROTEIN INTERACTIONS , Shiden T. Azaria

Chemical Vapor Deposition of Two-Dimensional Materials and Heterostructures , Alex J. Boson

Bioinformatic and Biophysical Analyses of Proteins , Jonathan Catazaro

Developing Functionalized Peroxide Precursors for the Synthesis of Cyclic and Spirocyclic Ethers , Anna J. Diepenbrock

Decarboxylative Elimination for the Systhesis of Olefins Via Photoredox/Cobalt Dual Catalysis , Renjie Gui

Enantioselective γ- and δ -Borylation of Unsaturated Carbonyl Derivatives: Synthesis, Mechanistic Insights, and Applications. , Gia L. Hoang

Entrapment of proteins in high-performance affinity columns for chromatographic studies of drug-protein interactions , Saumen Poddar, Elliott Rodriguez, Shiden Azaria, and David S. Hage

Genetic Code Expansion in Biochemical Investigations and Biomedical Applications , Nanxi Wang

Applying the Diffusion of Innovation Theory to Characterize STEM Faculty Attending Professional Development Programs , Dihua Xue

Who is attending pedagogical workshops? Applying the Innovation Diffusion to Characterize Faculty Attendees , Victoria Dihua Xue, Trisha Vickrey, and Marilyne Stains

Genetically Encoded Fluorescent Protein Biosensor for Nitric Oxide , Wenjia Zhai

STUDIES IN DIRECTED CATALYTIC ASYMMETRIC HYDROBORATION OF 1,2-DISUBSTITUTED UNSATURATED AMIDE , Shuyang Zhang

Synthesis and Applications of Cyclobutenes , Benjamin Enns

Binding of Oxygen to Human Hemoglobin Within the Erythrocyte Using ICAM Spectrophotometry , Kyle K. Hill

Design and Synthesis of Novel Octacarboxy Porphyrinic Metal-Organic Frameworks , Jacob A. Johnson

Development of a Direct Activity Probe for Rho-Associated Protein Kinase , Maia Kelly

Thermolysis of Hypervalent Iodine Complexes: Synthesis of Fluorinated Radiotracers for Positron Emission Tomography and Synthesis of Quaternary α-Alkyl α-Aryl Amino Acids , Jayson J. Kempinger

Synthesis and Applications of Lanthanide Sulfides and Oxides , Christopher Marin

SELECTIVE IODINATION USING DIARYLIODONIUM SALTS , William H. Miller IV

MOLECULAR MECHANISM FOR THE BIOSYNTHESIS AND REGULATION OF SECONDARY METABOLITES IN LYSOBACTER , Simon Tesfamichael Tombosa

STUDIES IN ASYMMETRIC CATALYSIS: SUPRAMOLECULAR CATALYSIS AND BORANE-ASSISTED HYDROGENATION , Kazuya Toyama

Molecular Mechanism for the Biosynthesis of Antifungal HSAF and Antibacterial WAP-8294A2 , Haotong Chen

Toward the Probing of DHQS Activity by Protein Engineering through the Introduction of Unnatural Amino Acids and the Selection of tRNA/tRNA Synthetase Pairs , Shaina E. Ives

Toward an Expanded Role for Collision-Induced Dissociation in Glycoproteomic Analysis , Venkata Kolli

New Methods for Synthesis of Organic Peroxides and Application of Peroxide Electrophiles to Synthesis of Functionalized Ethers , Shiva Kumar Kyasa

Chromatographic Analysis of Drug-Protein Interactions During Diabetes and Characterization of Human Serum Albumin Through Multidimensional Mass Spectrometry , Ryan E. Matsuda

THREE-DIMENSIONAL SCAFFOLDS OF GRAPHENE, CARBON NANOTUBES AND TRANSITION-METAL OXIDES FOR APPLICATIONS IN ELECTRONICS, SENSORS AND ENERGY STORAGE , Gilbert N. Mbah

TOWARD THE MEASUREMENT OF BIODISTRIBUTION OF 18 F-LABELED INDUSTRIAL CHEMICALS WITH POSITRON EMISSION TOMOGRAPHY (PET) , Katelyenn S. McCauley

Investigations into the Molecular Mechanisms of Bacterial Pathogen-Host Interactions: Construction of a Dual Plasmid System for Incorporation of Unnatural Amino Acids into Pseudomonas syringae pv. tomato DC3000 , Scotty D. Raber

Applications of High Performance Affinity Chromatography with High Capacity Stationary Phases Made by Entrapment , John A. Vargas Badilla

Uses of Diaryliodonium Salts and Methods for their Synthesis , Jordan M. Veness

The intersection of nuclear magnetic resonance and quantum chemistry , Yali Wang

Chemometric and Bioinformatic Analyses of Cellular Biochemistry , Bradley Worley

Analysis of Free Solute Fractions and Solute-Protein Interactions Using Ultrafast Affinity Extraction and Affinity Microcolumns , Xiwei Zheng

The 8-Silyloxyquinoline Scaffold as a Versatile Platform for the Sensitive Detection of Aqueous Fluoride , Xinqi Zhou

Nanostructured Cerium Oxide Based Catalysts: Synthesis, Physical Properties, and Catalytic Performance , Yunyun Zhou

Hydrolytically Stable Analogues of Sugar Phosphates and a Miniaturized in Situ Enzymatic Screen , Xiang Fei

Development and Application of Combined Quantum Mechanical and Molecular Mechanical Methods , Rui Lai

Syntheses of Aminyl Diradicals and Nitroxide Tetra- and Octaradicals , Arnon Olankitwanit

Analysis of Drug Interactions with Lipoproteins by High Performance Affinity Chromatography , Matthew R. Sobansky

Studies in Asymmetric Synthesis: Supramolecular Catalysis, C-H Activation, and D-Cycloserine Synthesis , Nathan C. Thacker

Application of Nuclear Magnetic Resonance Based Metabolomics to Study the Central Metabolism of Staphylococci , Bo Zhang

IMPLEMENTATION AND APPLICATION OF THE MMFF94 FORCE FIELD , Hongbo Zhu

The Electrochemical Analysis of Bovine Bone Derived Supercapacitors, Organic Peroxide Explosives, and Conducting Polymer Nanojunctions , Paul Goodman

The Development and Applications of NMR Metabolomics Analysis of Bacterial Metabolomes , Steven M. Halouska

Utilizing NMR Spectroscopy and Molecular Docking as Tools for the Structural Determination and Functional Annotation of Proteins , Jaime Stark

A. Catalysis of CO-PROX by Water-Soluble Rhodium Fluorinated Porphyrins B. Studies toward Fluorination of Electron Rich Aromatics by Nucleophilic Fluoride , Shri Harsha Uppaluri

Regulation of Secondary Metabolism in Lysobacter enzymogenes : Studies of Intercellular and Intracellular Signaling , Stephen J. Wright

DIRECTED CATALYTIC ASYMMETRIC HYDROBORATION OF 1,1-DISUBSTITUTED ALKENES , Mohammad Odeh Bani Khaled

I. Synthesis of β-Sitosterol and Phytosterol Esters; II. New Methodology for Singlet Oxygen Generation from 1,1-Dihydroperoxides , Jiliang Hang

Experimental and Theoretical Studies in Solid-state Nuclear Magnetic Resonance , Monica N. Kinde

Experimental and Theoretical Studies in Nuclear Magnetic Resonance , John D. Persons

RHODIUM-CATALYZED HYDROBORATION OF 1,1-DISUBSTITUTED ALKENES , Scott A. Pettibone

INVESTIGATIONS OF INTER- AND INTRAMOLECULAR C-O BOND FORMING REACTIONS OF PEROXIDE ELECTROPHILES , Benjamin W. Puffer

The Use of Rhenium (VII) Oxide as a Catalyst for the Substution of Hemiacetals , Michael W. Richardson

Characterization of Novel Macrocyclic Polyether Modified Pseudostationary Phases for use in Micellar Electrokinetic Chromatography and Development of a Chemiluminescence Presumptive Assay for Peroxide-based Explosives , Raychelle Burks

Preparation and Characterization of Biomimetic Hydroxyapatite-Resorbable Polymer Composites for Hard Tissue Repair , Kristopher R. Hiebner

High Yield Synthesis of Positron Emission Tomography Ligands for Metabotropic Glutamate Receptor Imaging , Saraanne E. Hitchcock

Optimization and Implementation of Entrapment: A Novel Immobilization Technique for High-performance Affinity Chromatography , Abby J. Jackson

Fabrication and Catalytic Property of Cerium Oxide Nanomaterials , Keren Jiang

Affinity Chromatography in Environmental Analysis and Drug-Protein Interaction Studies , Efthimia Papastavros

Development and Optimization of Organic Based Monoliths for Use in Affinity Chromatography , Erika L. Pfaunmiller

I. An Improved Procedure for Alkene Ozonolysis. II. Exploring a New Structural Paradigm for Peroxide Antimalarials. , Charles Edward Schiaffo

QUANTUM MECHANICAL AND MOLECULAR MECHANICAL STUDY OF SOLVENT EFFECTS , Dejun Si

Resorbable Polymer-Hydroxyapatite Composites for Bone Trauma Treatment: Synthesis and Properties , Troy E. Wiegand

PURIFICATION OF LYSINE DECARBOXYLASE: A MODEL SYSTEM FOR PLP ENZYME INHIBITOR DEVELOPMENT AND STUDY , Leah C. Zohner

Characterization of Glycation Sites on Human Serum Albumin using Mass Spectrometry , Omar S. Barnaby

HIGH TEMPERATURE RARE EARTH COMPOUNDS: SYNTHESIS, CHARACTERIZATION AND APPLICATIONS IN DEVICE FABRICATION , Joseph R. Brewer

Classification, Synthesis and Characterization of Pyridyl Porphyrin Frameworks , Lucas D. DeVries

Ultrasonic Activation of Triacetone Triperoxide , LaTravia R. Dobson

Characteristics and Stability of Oxide Films on Plutonium Surfaces , Harry Guillermo García Flores

Controlling Reductive Elimination From Novel I(III) Salts Using a SECURE Method , Joseph W. Graskemper

I. A NEW SYNTHETIC APPROACH TO THE SYNTHESIS OF N-(PHOSPHONOACETYL)-L-ORNITHINE, II. THE INFLUENCE OF PYRIDINE ON THE OZONOLYSIS OF ALKENES , Bradley M. Johnson

Chromatographic Studies of Drug-Protein Binding in Diabetes , Kathryn (Krina) S. Joseph

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Research Techniques in Organic Chemistry

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research paper topics in organic chemistry pdf

Recent Advances in the Application of P(III)-Nucleophiles to Create New P−C Bonds through Michaelis–Arbuzov-Type Rearrangement

  • Biquan Xiong
  • Minjing Yuan
  • Ke-Wen Tang

research paper topics in organic chemistry pdf

Chemical Aspects of Halide Perovskite Nanocrystals

  • Mrinmoy Roy
  • Milan Sykora

research paper topics in organic chemistry pdf

Unlocking Diversity: From Simple to Cutting-Edge Synthetic Methodologies of Bis(indolyl)methanes

  • Pankaj Teli
  • Shivani Soni
  • Shikha Agarwal

research paper topics in organic chemistry pdf

Bioorthogonal Reactions in Bioimaging

  • Eszter Kozma

research paper topics in organic chemistry pdf

Pt(IV) Complexes in the Search for Novel Platinum Prodrugs with Promising Activity

  • Sainath Aher

research paper topics in organic chemistry pdf

Recent Progress in Phenoxazine-Based Thermally Activated Delayed Fluorescent Compounds and Their Full-Color Organic Light-Emitting Diodes

  • Houda Al-Sharji
  • Rashid Ilmi
  • Muhammad S. Khan

research paper topics in organic chemistry pdf

Transition-Metal Catalyzed Synthesis of Pyrimidines: Recent Advances, Mechanism, Scope and Future Perspectives

  • Vipin K. Maikhuri
  • Divya Mathur
  • Brajendra K. Singh

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Palladium N -Heterocyclic Carbene-Catalyzed Aminations: An Outline

  • S. B. Umabharathi
  • Mohan Neetha
  • Gopinathan Anilkumar

research paper topics in organic chemistry pdf

Bioorthogonal Chemistry in Cellular Organelles

  • Veronika Šlachtová
  • Marek Chovanec
  • Milan Vrabel

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Photo-activatable Reagents for Bioorthogonal Ligation Reactions

  • Heyang Zhang

research paper topics in organic chemistry pdf

Recent Advances in Bioorthogonal Ligation and Bioconjugation

  • Florian M. Zielke
  • Floris P. J. T. Rutjes

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Progress of Metal Nanomaterial Controllable Preparation by Photoreduction

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Recent Advances in Palladium-Catalyzed [4 +  n ] Cycloaddition of Lactones, Benzoxazinanones, Allylic Carbonates, and Vinyloxetanes

  • Mengyan Guo
  • Panke Zhang

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The Renaissance of Ferrocene-Based Electrocatalysts: Properties, Synthesis Strategies, and Applications

  • Anitha Varghese

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Principles of Photocatalysts and Their Different Applications: A Review

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  • Mohamed A. El-Nemr
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Construction of 1,4-Dihydropyridines: The Evolution of C4 Source

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C–H Bond Functionalization of N -Heteroarenes Mediated by Selectfluor

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Functionalization of BODIPY Dyes with Additional C–N Double Bonds and Their Applications

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Recent Advances in MXene Quantum Dots: A Platform with Unique Properties for General-Purpose Functional Materials with Novel Biomedical Applications

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  • Nafiseh Einafshar
  • Majid Khazaei

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The Novel Organic Emitters for High-Performance Narrow-Band Deep Blue OLEDs

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Recent Progress on Nitrogen-Rich Energetic Materials Based on Tetrazole Skeleton

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Performance Regulation of Single-Atom Catalyst by Modulating the Microenvironment of Metal Sites

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Recent Progress in NiH-Catalyzed Linear or Branch Hydrofunctionalization of Terminal or Internal Alkenes

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Structure-Based Drug Design of RdRp Inhibitors against SARS-CoV-2

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  • Afsheen Saba
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The Intramolecular Povarov Tool in the Construction of Fused Nitrogen-Containing Heterocycles

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Multicomponent Reactions Using C , N -Binucleophilic Nature of Aminopyrazoles: Construction of Pyrazole-Fused Heterocycles

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Laser-Induced Transfer of Functional Materials

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Oxime Esters: Flexible Building Blocks for Heterocycle Formation

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Spectroscopic Determination of Acetylcholine (ACh): A Representative Review

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Photocatalytic Synthesis of Hydrogen Peroxide from Molecular Oxygen and Water

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Strategies Toward the Catalyst-Free α-C–H Functionalizations of Tertiary Amines

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Solid-State Nanopore/Nanochannel Sensing of Single Entities

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Synthetic Approaches, Biological Activities, and Structure–Activity Relationship of Pyrazolines and Related Derivatives

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Conjugates of Tetrapyrrolic Macrocycles as Potential Anticancer Target-Oriented Photosensitizers

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Critical Analysis of Hydrogen Production by Aqueous Methanol Sonolysis

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A Modern Look at Spiropyrans: From Single Molecules to Smart Materials

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Aryl- and Superaryl-Extended Calix[4]pyrroles: From Syntheses to Potential Applications

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Promising Nitrogen-Doped Graphene Derivatives; A Case Study for Preparations, Fabrication Mechanisms, and Applications in Perovskite Solar Cells

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Shape and Stability Matter: Enhanced Catalytic Reactions via Sol–gel-Entrapped Catalysts

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O -Benzoylhydroxylamines: A Versatile Electrophilic Aminating Reagent for Transition Metal-Catalyzed C–N Bond-Forming Reactions

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Water-Soluble Carbon Monoxide-Releasing Molecules (CORMs)

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Designs and Applications of Multi-stimuli Responsive FRET Processes in AIEgen-Functionalized and Bi-fluorophoric Supramolecular Materials

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Greener Syntheses of Coumarin Derivatives Using Magnetic Nanocatalysts: Recent Advances

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Recent Advances in the Use of Dimethyl Sulfoxide as a Synthon in Organic Chemistry

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Obtaining Water from Air Using Porous Metal–Organic Frameworks (MOFs)

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Recent Advances in Semiconductor Heterojunctions and Z-Schemes for Photocatalytic Hydrogen Generation

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In Situ TEM under Optical Excitation for Catalysis Research

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Solar-Driven Photocatalytic Films: Synthesis Approaches, Factors Affecting Environmental Activity, and Characterization Features

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  • Romana Cerc Korošec
  • Urška Lavrenčič Štangar

research paper topics in organic chemistry pdf

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Library Home

Organic Chemistry I

(4 reviews)

research paper topics in organic chemistry pdf

Xin Liu, Kwantlen Polytechnic University

Copyright Year: 2021

ISBN 13: 9781989864524

Publisher: Kwantlen Polytechnic University

Language: English

Formats Available

Conditions of use.

Attribution-NonCommercial-ShareAlike

Learn more about reviews.

Reviewed by Ratanmani Joshi, Professor, Tidewater Community College on 2/23/23

The text covers most areas and ideas of the subject and does provide good glossary. read more

Comprehensiveness rating: 5 see less

The text covers most areas and ideas of the subject and does provide good glossary.

Content Accuracy rating: 5

There are very few errors, but overall it is accurate and unbiased.

Relevance/Longevity rating: 5

The book is quite relevant, since it covers most basic concepts of Organic chemistry I for freshman and sophomore students.

Clarity rating: 4

Book content is very clear, but some more example could have been included for practice purpose.

Consistency rating: 5

All terminologies mentioned in the test are very well explained.

Modularity rating: 5

I really like the way sections are broken for each chapter.

Organization/Structure/Flow rating: 4

Book organization/ structure/flow are good except certain topics are omitted out. For example in the spectroscopy chapter, the author should have included introduction of mass spectroscopy also along with IR and NMR.

Interface rating: 5

No interface issues.

Grammatical Errors rating: 5

Few grammatical error but overall concepts can be understood.

Cultural Relevance rating: 5

No cultural relevance in the book.

Overall the book is really good a an OER option. Covers major concepts of Organic Chemistry I for students. However more practice problems could be included with each chapter.

Reviewed by Hermann Christine, Chair, Full Professor, Radford University on 1/10/23

This textbook covers most topics in the first semester of the year-long Organic Chemistry sequence. More examples of IR and NMR interpretation and nomenclature examples are needed. Many topics are not covered in much detail such as nomenclature... read more

Comprehensiveness rating: 3 see less

This textbook covers most topics in the first semester of the year-long Organic Chemistry sequence. More examples of IR and NMR interpretation and nomenclature examples are needed. Many topics are not covered in much detail such as nomenclature and VSEPR. An index, glossary, and many end of chapter problems would be useful.

The material that is presented is accurate.

Relevance/Longevity rating: 4

Real world examples would improve the textbook, as students want to know how this relates to their real life. The topics that are included are the basics of organic chemistry.

The text is written so that it is easy to understand. However, the numerous typos distract from the text. The examples that are present are illustrated well. However, many more examples and problems are needed.

The textbook is consistent throughout in style. Color pictures explain topics well.

The headings and sub-headings are excellent. Many more examples are needed for students. All students need many examples to understand the topic.

Organization/Structure/Flow rating: 5

The topics are presented in a logical manner. However, more examples are needed to explain the concepts.

The images are clear and easy to read. Table of contents is easy to follow.

Grammatical Errors rating: 3

Numerous typos are in the textbook. For example, carbocation is labelled carocation

The chemistry topics are listed typical for an organic book. These are facts and not related to culture.

It is a basic organic book for the first semester of Organic Chemistry. However, it does not give enough explanation or examples for many topics.

Reviewed by SATHIAMOORTHY BALASUBRAMANIAN, Chemistry FACULTY, Rochester Community & Technical College on 12/11/22

This text book covers all the chapters required for 1st semester of Organic chemistry course. It is comprehensive yet precise in outlining the various concepts involved. read more

This text book covers all the chapters required for 1st semester of Organic chemistry course. It is comprehensive yet precise in outlining the various concepts involved.

Content Accuracy rating: 4

Appears accurate and error free on basic reading.

This text book is highly relevant for understanding the fundamentals of Organic chemistry course. The various concepts are well organized and explained in detail. This book can be used by a student to self teach the principles in Organic chemistry.

Clarity rating: 5

This text book is easy to understand and is supplemented by excellent examples. I would specially highlight the various examples given in the text book as they are the tools which lead to clear understanding.

Is consistent throughout

The author has well thought out the various sections in the text book. One can use any of these sections in providing assignments to students.

Well organized and easy to understand. It has a connect from one concept to another likewise from one chapter to another.

There aren't any interface issues.

There are grammatical errors in tense used but it shouldn't be an issue in understanding the concepts being dealt in the book.

Cultural Relevance rating: 1

Not applicable

A well written organic chemistry text book for Freshman and sophomore students. Some grammatical errors need to be corrected but that doesn't cause issues in understanding the concepts being dealt. I would surely recommend students to utilize the examples and questions given in this book for further practice and better understanding of principles of Organic Chemistry

Reviewed by Maggie Bump, Senior Instructor, Virginia Tech on 5/23/22

This text covers half of the standard undergraduate Organic Chemistry concepts and reactions and is reasonable coverage for one semester of the course. The text does not address polymers, pharmaceuticals, biomaterials, or green chemistry. These... read more

Comprehensiveness rating: 4 see less

This text covers half of the standard undergraduate Organic Chemistry concepts and reactions and is reasonable coverage for one semester of the course. The text does not address polymers, pharmaceuticals, biomaterials, or green chemistry. These evolving areas will need to be incorporated by the professor. Inclusion of an index, glossary, and summary of reactions would be a great addition.

Content is accurate and unbiased.

The material included is up-to-date coverage of longstanding principles and reactions, content that does not change quickly. Real-world applications, such as vinyl polymerizations used on a large industrial scale, are not included but would improve the relevance of the text material.

The text is written at a level appropriate for freshmen and sophomore Organic Chemistry students. Examples and Common Error boxes are useful and well placed. The grammatical errors are distracting and may cause minor issues for some learning styles.

The text throughout the chapters is consistent in style and in level of both content and presentation of the content.

Chapters and subheadings are used effectively to make the text divisible into pre- and post- class readings, or for adapting the order of the material for customized coverage.

The topics are presented in a logical order and clear fashion.

The text is free of significant interface issues. Images appear clear and navigating between the table of contents and embedded links is logical and smooth.

There are several small grammatical errors, mainly verb tense and noun pluralization. These are distracting, but not inhibitory to understanding the content.

The chemistry is presented in a scientific manner. There are not statements of opinion, and there are not examples that are culturally insensitive.

For a new teacher of the subject, challenges include limited practice problems, no test questions, and no ‘fun facts’ showing real world examples. I am going to offer this text as a resource in my class this fall because it is well organized and written at an appropriate level, but I have been teaching the course for 20 years. I have developed resources for my classes, so having only this text is a fine fit for my class. I will use my notes, practice problems, homework sheets, and examples with this text.

Table of Contents

  • Chapter 1 Basic Concepts in Chemical Bonding and Organic Molecules
  • Chapter 2 Fundamental of Organic Structures
  • Chapter 3 Acids and Bases: Organic Reaction Mechanism Introduction
  • Chapter 4 Conformations of Alkanes and Cycloalkanes
  • Chapter 5 Stereochemistry
  • Chapter 6 Structural Identification of Organic Compounds: IR and NMR Spectroscopy
  • Chapter 7 Nucleophilic Substitution Reactions
  • Chapter 8 Elimination Reactions
  • Chapter 9 Free Radical Substitution Reaction of Alkanes
  • Chapter 10 Alkenes and Alkynes

Ancillary Material

About the book.

An open textbook that is suitable for the first semester of Organic Chemistry. Basic concepts of the structures and reactivities of organic molecules are covered in this open textbook. Besides the fundamental discussions of organic acids-bases, stereochemistry, IR and NMR, this book also includes the topics of substitution and elimination reactions, radical substitution of alkanes, preparation and reactions of alkenes and alkynes.

About the Contributors

Dr. Xin Liu has been a faculty member at the Department of Chemistry, KPU since 2008. Other than teaching Organic Chemistry and first-year General Chemistry courses, she has also been actively involved in curriculum review and new course development. Having a keen interest in Open Education Resource,  Dr. Liu hope to make more contributions in this fast growing area, to make learning accessible to everyone.

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