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Stem cells articles from across Nature Portfolio
Stem cells are cells that have the capacity to self-renew by dividing and to develop into more mature, specialised cells. Stem cells can be unipotent, multipotent, pluripotent or totipotent, depending on the number of cell types to which they can give rise.
Partial reprogramming of the mammalian brain
Xu and colleagues used partial OSKM reprogramming in aged mice to drive cell-type proportions of the subventricular zone to more youthful levels, which equates to qualified rejuvenation of a neurogenic niche that is defined, in part, by restoration of neuroblast levels.
- Niels C. Asmussen
- Marissa J. Schafer
Exit from totipotency is controlled by DUXBL in mice
In mice, zygotic genome activation occurs at onset of the two-cell stage in embryonic development and coincides with the exit from totipotency. Our work shows that the transcription factor DUXBL participates in silencing part of the stage-specific two-cell-associated transcriptional program and is required for development to proceed.
Mapping human hematopoiesis
Understanding normal hematopoiesis is critical to understanding disease. Technological advances are driving insight into human hematopoiesis at unprecedented resolution. Integrating ‘-omics’ datasets with machine learning has yielded a high-resolution map of primary human bone marrow hematopoietic progenitor cells that supports the study of immune cell development, as well as the origins of disease.
- Kathrin M. Bernt
Related Subjects
- Adult stem cells
- Cancer stem cells
- Embryonic germ cells
- Embryonic stem cells
- Epigenetic memory
- Haematopoietic stem cells
- Heart stem cells
- Intestinal stem cells
- Mammary stem cells
- Mesenchymal stem cells
- Multipotent stem cells
- Muscle stem cells
- Neural stem cells
- Pluripotent stem cells
- Regeneration
- Reprogramming
- Self-renewal
- Skin stem cells
- Stem-cell differentiation
- Stem-cell niche
- Totipotent stem cells
- Transdifferentiation
Latest Research and Reviews
Comparison studies identify mesenchymal stromal cells with potent regenerative activity in osteoarthritis treatment
- Hongshang Chu
- Shaoyang Zhang
The PTM profiling of CTCF reveals the regulation of 3D chromatin structure by O-GlcNAcylation
CTCF, which is known to play critical role in chromatin structure, undergoes post-translational modifications (PTMs). In this research, O-GlcNAcylation was found to inhibit CTCF binding, impacting 3D chromatin structure, gene expression and cellular development.
- Xiuxiao Tang
- Pengguihang Zeng
- Junjun Ding
Mesenchymal stromal cells with chimaeric antigen receptors for enhanced immunosuppression
Antigen-specific immunosuppression can be enhanced by genetically modifying mesenchymal stromal cells with chimaeric antigen receptors, as shown for the treatment of graft-versus-host disease in mice.
- Olivia Sirpilla
- R. Leo Sakemura
- Saad S. Kenderian
Bioengineering of vascularized porcine flaps using perfusion-recellularization
- Michael S. Xu
- Andrew D’Elia
- Siba Haykal
Cyclophilin A supports translation of intrinsically disordered proteins and affects haematopoietic stem cell ageing
Maneix, Iakova and colleagues report that cyclophilin A is a chaperone for, and regulator of, intrinsically disordered proteins within haematopoietic stem and progenitor cells, with potential effects on ageing-like phenotypes and lineage commitment.
- Laure Maneix
- Polina Iakova
- André Catic
Restoration of neuronal progenitors by partial reprogramming in the aged neurogenic niche
Xu et al. use single-cell transcriptomics to reveal that targeted and systemic partial reprogramming restore the production of neuronal progenitors and new neurons in old mice and show a cell-autonomous effect of reprogramming in cultures of aged neural stem cells.
- Julliana Ramirez-Matias
- Anne Brunet
News and Comment
Improving the EASIX’ predictive power for NRM in adults undergoing allogeneic hematopoietic cell transplantation
- Silvia Escribano-Serrat
- Luis Gerardo Rodríguez-Lobato
- María Queralt Salas
Powerful microscopy reveals blood-cell production in bone marrow
A method for imaging the production of blood cells in the bones of mice has revealed the organization of cell lineages, both in a steady state and in response to stressors, such as bleeding and infection.
- M. Carolina Florian
Glia-enriched cortical organoids implanted in mice capture astrocyte diversity
The underrepresentation of functional glial cells is a major challenge in brain organoid models. We developed an astroglia-enriched cortical organoid model that allows efficient generation of functional astrocytes and enables the formation of astroglial morphological subclasses with layer-specific gene expression profiles upon transplantation into the mouse brain.
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Stem cells are cells that have the capacity to self-renew by dividing and to develop into more mature, specialised cells. Stem cells can be unipotent, multipotent, pluripotent or totipotent ...