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When the media covers scientific research, not all scientists are equally likely to be mentioned. A new study finds scientists with Asian or African names were 15% less likely to be named in a story. shironosov/Getty Images hide caption

Perspective

Shots - health news, which scientists get mentioned in the news mostly ones with anglo names, says study.

April 19, 2024 • A new study finds that in news stories about scientific research, U.S. media were less likely to mention a scientist if they had an East Asian or African name, as compared to one with an Anglo name.

An artistic rendering of a washed-up Ichthyotitan severnensis carcass on the beach. Sergey Krasovskiy hide caption

An 11-year-old unearthed fossils of the largest known marine reptile

April 19, 2024 • When the dinosaurs walked the Earth, massive marine reptiles swam. Among them, a species of Ichthyosaur that measured over 80 feet long. Today, we look into how a chance discovery by a father-daughter duo of fossil hunters furthered paleontologist's understanding of the "giant fish lizard of the Severn." Currently, it is the largest marine reptile known to scientists.

The Science of Siblings

Comic: our sun was born with thousands of other stars. where did they all go.

April 18, 2024 • Our sun was born in a cosmic cradle with thousands of other stars. Astrophysicists say they want to find these siblings in order to help answer the question: Are we alone out there?

Surgeon Christoph Haller and his research team from Toronto's Hospital for Sick Children are working on technology that could someday result in an artificial womb to help extremely premature babies. Chloe Ellingson for NPR hide caption

An artificial womb could build a bridge to health for premature babies

April 12, 2024 • Artificial wombs could someday save babies born very prematurely. Even though the experimental technology is still in animal tests, there are mounting questions about its eventual use with humans.

In the womb, a brother's hormones can shape a sister's future

April 9, 2024 • When siblings share a womb, sex hormones from a male fetus can cause lasting changes in a female littermate. This effect exists for all kinds of mammals — perhaps humans too.

The black-capped chickadee, seen here, is well known for its strong episodic memory. Dmitriy Aronov hide caption

The "barcodes" powering these tiny songbirds' memories may also help human memory

April 5, 2024 • Tiny, black-capped chickadees have big memories. They stash food in hundreds to thousands of locations in the wild – and then come back to these stashes when other food sources are low. Now, researchers at Columbia University's Zuckerman Institute think neural activity that works like a barcode may be to thank for this impressive feat — and that it might be a clue for how memories work across species.

The "barcodes" powering these tiny songbirds' memories may also help human memory

"One second doesn't sound like much, but in today's interconnected world, getting the time wrong could lead to huge problems," geophysicist Duncan Agnew says. Here, an official clock is seen at a golf tournament in Cape Town, South Africa. Johan Rynners/Getty Images hide caption

Negative leap second: Climate change delays unusual step for time standard

March 30, 2024 • We're nearing a year when a negative leap second could be needed to shave time — an unprecedented step that would have unpredictable effects, a new study says.

A researcher holds up a sandy De Winton's golden mole. Nicky Souness/Endangered Wildlife Trust hide caption

Once lost to science, these "uncharismatic" animals are having their moment

March 29, 2024 • Historic numbers of animals across the globe have become endangered or pushed to extinction. But some of these species sit in limbo — not definitively extinct yet missing from the scientific record. Rediscovering a "lost" species is not easy. It can require trips to remote areas and canvassing a large area in search of only a handful of animals. But new technology and stronger partnerships with local communities have helped these hidden, "uncharismatic" creatures come to light.

Once lost to science, these "uncharismatic" animals are having their moment

The country's two biggest reservoirs are on the Colorado River. Water levels at Lake Powell have dropped steeply during the two-decade megadrought. Justin Sullivan/Getty Images hide caption

The Colorado River rarely reaches the sea. Here's why

March 28, 2024 • More than half of the Colorado River's water is used to grow crops, primarily livestock feed, a new study finds. The river and its users are facing tough decisions as the climate warms.

A post-reproductive toothed whale mother and her son. David Ellifrit/Center for Whale Research hide caption

Most animals don't go through menopause. So why do these whales?

March 22, 2024 • Across the animal kingdom, menopause is something of an evolutionary blip. We humans are one of the few animals to experience it. But Sam Ellis , a researcher in animal behavior, argues that this isn't so surprising. "The best way to propagate your genes is to get as many offspring as possible into the next generation," says Ellis. "The best way to do that is almost always to reproduce your whole life."

A cicada perches on a picnic table in front of Nolde Mansion in Cumru Township, PA in May 2021. New research shows that these insects urinate in a surprising way. Ben Hasty / MediaNews Group/Reading Eagle via Getty Images hide caption

Scientists studied how cicadas pee. Their insights could shed light on fluid dynamics

March 20, 2024 • Cicadas, and the way they urinate, offer a 'perfect' lab for understanding fluid dynamics at very small scales, researchers say

Workers at the U.S. Embassy in Havana leave the building in September 2017. New research out of the National Institutes of Health finds no unusual pattern of damage in the brains of Havana syndrome patients. Emily Michot/Miami Herald/Tribune News Service via Getty Images hide caption

In Havana syndrome patients, NIH scientists find no physical trace of harm

March 18, 2024 • The mysterious ailments that became known as Havana syndrome left no physical evidence of injury or disease, according to two government studies.

This close-up of the Verona astrolabe shows Arabic and Hebrew markings. Federica Gigante hide caption

This medieval astrolabe has both Arabic and Hebrew markings. Here's what it means

March 16, 2024 • This discovery sheds new light on the rich history of scholarship and intellectual exchange between Muslims, Jews and Christians during a time of Muslim rule in medieval Spain.

Flares burn off methane and other hydrocarbons at an oil and gas facility in Lenorah, Texas in 2021. New research shows drillers emit about three times as much climate-warming methane as official estimates. David Goldman/AP hide caption

Oil and gas companies emit more climate-warming methane than EPA reports

March 13, 2024 • Oil and gas drillers are releasing more climate-warming methane than the government estimates, a new study shows.

This type of staghorn coral ( Acropora pulchra ) appeared to benefit from the presence of sea cucumbers ( Holothuria atra ), a new study finds. Terry Moore/Stocktrek Images / Science Source hide caption

This often-overlooked sea creature may be quietly protecting the planet's coral reefs

March 13, 2024 • The pickle-shaped bottom feeders may reduce the amount of microbes on the seafloor that could potentially sicken coral, scientists suggest

Millions of people are affected by long COVID, a disease that encompasses a range of symptoms — everything from brain fog to chronic fatigue — and that manifests differently across patients. The Washington Post/The Washington Post via Getty Images hide caption

What we know about long COVID — from brain fog to physical fatigue

March 13, 2024 • "Long COVID has affected every part of my life," said Virginia resident Rachel Beale said at a recent Senate hearing. "I wake up every day feeling tired, nauseous and dizzy. I immediately start planning when I can lay down again." Beale is far from alone. Many of her experiences have been echoed by others dealing with long COVID. It's a constellation of debilitating symptoms that range from brain fog and intense physical fatigue to depression and anxiety. But there's new, promising research that sheds light onto some symptoms. NPR health correspondent Will Stone talks with Short Wave host Regina G. Barber about the state of long COVID research — what we know, what we don't and when we can expect treatments or even cures for it. Have more COVID questions you want us to cover? Email us at [email protected] — we'd love to hear from you.

Maria E. Garay-Serratos holds a framed photograph of her mother, who died after suffering decades of domestic violence. Scientists are trying to understand how domestic violence damages the brain. Julio Serratos/Maria E. Garay-Serratos hide caption

Domestic violence may leave telltale damage in the brain. Scientists want to find it

March 8, 2024 • Traumatic brain injuries from intimate partner violence are common, and potentially more severe than those seen in sports.

Elephantnose Fish, Gnathonemus petersii, Congo ullstein bild hide caption

The "shocking" tactic electric fish use to collectively sense the world

March 8, 2024 • Neuroscientist Nathan Sawtell has spent a lot of time studying the electric elephantnose fish. These fish send and decipher weak electric signals, which Sawtell hopes will eventually help neuroscientists better understand how the brain filters sensory information about the outside world. As Sawtell has studied these electric critters, he's had a lingering question: why do they always seem to organize themselves in a particular orientation. At first, he couldn't figure out why, but a new study released this week in Nature may have an answer: the fish are creating an electrical network larger than any field a single fish can muster alone, and providing collective knowledge about potential dangers in the surrounding water.

The "shocking" tactic electric fish use to collectively sense the world

A digital illustration of a circle of hands extending from the edge of the image, each holding a sheet of paper. The papers overlap in the center and, like a puzzle, come together to reveal a drawing of a handgun. Oona Tempest/KFF Health News hide caption

Meet the public health researchers trying to rein in America's gun violence crisis

Kff health news.

March 6, 2024 • After the 1996 Dickey Amendment halted federal spending on gun violence research, a small group of academics pressed on, with little money or support. Now a new generation is taking up the charge.

This artist's concept shows the Voyager 1 spacecraft entering the space between stars. Interstellar space is dominated by plasma, ionized gas (illustrated here as brownish haze). NASA/JPL-Caltech hide caption

The Voyager 1 spacecraft has a big glitch. Now, NASA must figure out how to fix it

March 6, 2024 • The Voyager 1 space probe is the farthest human-made object in space. It launched in 1977 with a golden record on board that carried assorted sounds of our home planet: greetings in many different languages, dogs barking, and the sound of two people kissing, to name but a few examples. The idea with this record was that someday, Voyager 1 might be our emissary to alien life – an audible time capsule of Earth's beings. Since its launch, it also managed to complete missions to Jupiter and Saturn. In 2012, it crossed into interstellar space.

A case of bronchitis in 2014 left Sanna Stella, a therapist who lives in the Chicago area, with debilitating fatigue. Stacey Wescott/Tribune News Service via Getty Images hide caption

Clues to a better understanding of chronic fatigue syndrome emerge from a major study

February 23, 2024 • After seven years of research, the findings shed light on the long-neglected illness. Scientists say the results could lead to future trials for potential treatments.

A 3D model of a short section of the stone wall. The scale at the bottom of the image measures 50 cm. Photos by Philipp Hoy, University of Rostock; model created using Agisoft Metashape by J. Auer, LAKD M-V hide caption

Scientists scanning the seafloor discover a long-lost Stone Age 'megastructure'

February 22, 2024 • The more than half mile long wall, called the Blinkerwall, was likely used by Stone Age hunter-gatherers to herd reindeer toward a shooting blind.

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Our picture of habitability on Europa, a top contender for hosting life, is changing

The moon of Jupiter is considered one of the most promising places to look for life, but its subsurface ocean may be less habitable than once thought.

A new road map shows how to prevent pandemics

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These windpipe cells trigger coughs to keep water out of the lungs

Jupiter’s moon Io may have been volcanically active ever since it was born

Hibernating bumblebee queens have a superpower: Surviving for days underwater

A puzzling mix of artifacts raises questions about Homo sapiens ' travels to China

Trending stories.

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Social media harms teens’ mental health, mounting evidence shows. What now?

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A protein found in sweat may protect people from Lyme disease

The protein stopped Borrelia burgdorferi, a bacterium that is transmitted by ticks, from growing in dishes or infecting mice.

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1 Cite Share Small extracellular vesicles from young plasma reverse age-related functional declines by improving mitochondrial energy metabolism. Chen X, Luo Y, Zhu Q, Zhang J, Huang H, Kan Y, Li D, Xu M, Liu S, Li J, Pan J, Zhang L, Guo Y, Wang B, Qi G, Zhou Z, Zhang CY, Fang L, Wang Y, Chen X. Chen X, et al. Nat Aging. 2024 Apr 16. doi: 10.1038/s43587-024-00612-4. Online ahead of print. Nat Aging. 2024. PMID: 38627524 Cite Share Item in Clipboard

2 Cite Share Dual-role transcription factors stabilize intermediate expression levels. He J, Huo X, Pei G, Jia Z, Yan Y, Yu J, Qu H, Xie Y, Yuan J, Zheng Y, Hu Y, Shi M, You K, Li T, Ma T, Zhang MQ, Ding S, Li P, Li Y. He J, et al. Cell. 2024 Apr 10:S0092-8674(24)00314-3. doi: 10.1016/j.cell.2024.03.023. Online ahead of print. Cell. 2024. PMID: 38631355 Cite Share Item in Clipboard

3 Cite Share ITPRIPL1 binds CD3ε to impede T cell activation and enable tumor immune evasion. Deng S, Zhang Y, Wang H, Liang W, Xie L, Li N, Fang Y, Wang Y, Liu J, Chi H, Sun Y, Ye R, Shan L, Shi J, Shen Z, Wang Y, Wang S, Brosseau JP, Wang F, Liu G, Quan Y, Xu J. Deng S, et al. Cell. 2024 Apr 5:S0092-8674(24)00310-6. doi: 10.1016/j.cell.2024.03.019. Online ahead of print. Cell. 2024. PMID: 38614099 Cite Share Item in Clipboard

4 Cite Share Brain endothelial GSDMD activation mediates inflammatory BBB breakdown. Wei C, Jiang W, Wang R, Zhong H, He H, Gao X, Zhong S, Yu F, Guo Q, Zhang L, Schiffelers LDJ, Zhou B, Trepel M, Schmidt FI, Luo M, Shao F. Wei C, et al. Nature. 2024 Apr 17. doi: 10.1038/s41586-024-07314-2. Online ahead of print. Nature. 2024. PMID: 38632402 Cite Share Item in Clipboard

5 Cite Share Overall Survival with Adjuvant Pembrolizumab in Renal-Cell Carcinoma. Choueiri TK, Tomczak P, Park SH, Venugopal B, Ferguson T, Symeonides SN, Hajek J, Chang YH, Lee JL, Sarwar N, Haas NB, Gurney H, Sawrycki P, Mahave M, Gross-Goupil M, Zhang T, Burke JM, Doshi G, Melichar B, Kopyltsov E, Alva A, Oudard S, Topart D, Hammers H, Kitamura H, McDermott DF, Silva A, Winquist E, Cornell J, Elfiky A, Burgents JE, Perini RF, Powles T; KEYNOTE-564 Investigators. Choueiri TK, et al. N Engl J Med. 2024 Apr 18;390(15):1359-1371. doi: 10.1056/NEJMoa2312695. N Engl J Med. 2024. PMID: 38631003 Clinical Trial. Cite Share Item in Clipboard

6 Cite Share Orphan Nuclear Receptor NR4A3 Promotes Vascular Calcification via Histone Lactylation. Ma W, Jia K, Cheng H, Xu H, Li Z, Zhang H, Xie H, Zhuang L, Wang Z, Cui Y, Sun H, Yi L, Chen Z, Duan S, Sano M, Fukuda K, Lu L, Gao F, Zhang R, Yan X. Ma W, et al. Circ Res. 2024 Apr 17. doi: 10.1161/CIRCRESAHA.123.323699. Online ahead of print. Circ Res. 2024. PMID: 38629274 Cite Share Item in Clipboard

7 Cite Share Prasinezumab slows motor progression in rapidly progressing early-stage Parkinson's disease. Pagano G, Taylor KI, Anzures Cabrera J, Simuni T, Marek K, Postuma RB, Pavese N, Stocchi F, Brockmann K, Svoboda H, Trundell D, Monnet A, Doody R, Fontoura P, Kerchner GA, Brundin P, Nikolcheva T, Bonni A; PASADENA Investigators; Prasinezumab Study Group. Pagano G, et al. Nat Med. 2024 Apr 15. doi: 10.1038/s41591-024-02886-y. Online ahead of print. Nat Med. 2024. PMID: 38622249 Cite Share Item in Clipboard

8 Cite Share Body mass index, waist circumference, and mortality in subjects older than 80 years: a Mendelian randomization study. Lv Y, Zhang Y, Li X, Gao X, Ren Y, Deng L, Xu L, Zhou J, Wu B, Wei Y, Cui X, Xu Z, Guo Y, Qiu Y, Ye L, Chen C, Wang J, Li C, Luo Y, Yin Z, Mao C, Yu Q, Lu H, Kraus VB, Zeng Y, Tong S, Shi X. Lv Y, et al. Eur Heart J. 2024 Apr 16:ehae206. doi: 10.1093/eurheartj/ehae206. Online ahead of print. Eur Heart J. 2024. PMID: 38626306 Cite Share Item in Clipboard

9 Cite Share The antibody-drug conjugate landscape. Flynn P, Suryaprakash S, Grossman D, Panier V, Wu J. Flynn P, et al. Nat Rev Drug Discov. 2024 Apr 16. doi: 10.1038/d41573-024-00064-w. Online ahead of print. Nat Rev Drug Discov. 2024. PMID: 38627573 No abstract available. Cite Share Item in Clipboard

10 Cite Share A pan-cancer analysis of the microbiome in metastatic cancer. Battaglia TW, Mimpen IL, Traets JJH, van Hoeck A, Zeverijn LJ, Geurts BS, de Wit GF, Noë M, Hofland I, Vos JL, Cornelissen S, Alkemade M, Broeks A, Zuur CL, Cuppen E, Wessels L, van de Haar J, Voest E. Battaglia TW, et al. Cell. 2024 Apr 5:S0092-8674(24)00312-X. doi: 10.1016/j.cell.2024.03.021. Online ahead of print. Cell. 2024. PMID: 38599211 Free article. Cite Share Item in Clipboard

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Like Moths to a Flame? We May Need a New Phrase.

Over time researchers have found fewer of the insects turning up in light traps, suggesting they may be less attracted to some kinds of light than they once were.

By Veronique Greenwood

Una niña de 11 años encuentra el fósil de un inmenso réptil oceánico

Cuando Ruby Reynolds y su padre encontraron un fósil en una playa inglesa, no sabían que pertenecía a un ictiosaurio de unos 25 metros que nadó en la época de los dinosaurios.

By Kate Golembiewski

What’s the Best Way to Treat I.B.S.?

A new study suggests that certain dietary changes may be more effective than medication.

By Alice Callahan

Heat-Related E.R. Visits Rose in 2023, C.D.C. Study Finds

As record heat enveloped the nation, the rate of emergency room visits increased compared with the previous five years, a sign of the major health risks of high temperatures.

By Noah Weiland

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Recent developments in cancer research: Expectations for a new remedy

1 Department of Surgery and Science, Kyushu University, Fukuoka Japan

Qingjiang Hu

Yuta kasagi, masaki mori.

Cancer research has made remarkable progress and new discoveries are beginning to be made. For example, the discovery of immune checkpoint inhibition mechanisms in cancer cells has led to the development of immune checkpoint inhibitors that have benefited many cancer patients. In this review, we will introduce and describe the latest novel areas of cancer research: exosomes, microbiome, immunotherapy. and organoids. Exosomes research will lead to further understanding of the mechanisms governing cancer proliferation, invasion, and metastasis, as well as the development of cancer detection and therapeutic methods. Microbiome are important in understanding the disease. Immunotherapy is the fourth treatment in cancer therapy. Organoid biology will further develop with a goal of translating the research into personalized therapy. These research areas may result in the creation of new cancer treatments in the future.

Cancer research has made remarkable progress and new discoveries are beginning to be made. In this review, we will introduce and describe the latest novel areas of cancer research: exosomes, microbiomes, immunotherapy, and organoids.

1. INTRODUCTION

The cancer research field has developed significantly through use of new equipment and technology. One example of new technology is Next‐Generation Sequencing (NGS). Also known as high‐throughput sequencing, NGS is the catch‐all term used to describe a number of different modern nucleic acid sequencing technologies. These methods allow for much quicker and cheaper sequencing of DNA and RNA compared with the previously used Sanger sequencing, and as such have revolutionized the study of genomics and molecular biology. NGS also allows for easier detection of mutations in cancer samples, leading to development of many new agents that can be used to treat patients. For example, if the RAS gene status is detected as wild type in a colorectal cancer patient, then an anti‐EGFR antibody, such as cetuximab or panitumumab, can be used for treatment.

A liquid biopsy, also known as fluid biopsy or fluid phase biopsy, is the sampling and analysis of non‐solid biological tissue, primarily blood. 1 It is being used as a novel way to detect cancer. Like a traditional biopsy, this type of technique is mainly used as a diagnostic and monitoring tool for diseases, and also has the added benefit of being largely noninvasive. Therefore, liquid biopsies can be performed more frequently, allowing for better tracking of tumors and mutations over a duration of time. This technique may also be used to validate the effectiveness of a cancer treatment drug by taking multiple liquid biopsy samples in the span of a few weeks. It may also prove to be beneficial for monitoring relapse in patients after treatment.

Novel devices and drugs have also been developed and used for cancer treatment. For surgery procedures, robotic‐assisted laparoscopic surgery has evolved and made it possible to visualize the fine movement of the forceps in three dimensions. This method is now used in esophageal, gastric, and rectal cancer surgeries in Japan. 2 , 3 , 4

Recently, immunotherapy became an additional method for treating cancer patients. The discovery of the immune checkpoint by Dr Honjo led to the development of immune checkpoint inhibitors. 5 Despite these developments, gastrointestinal cancers are still a major problem in need of new treatment methods. In this review, we introduce and describe four new areas of cancer research that may contribute to cancer treatment in the future: exosomes, microbiome, immunotherapy, and organoids.

2. AN APPLICATION OF EXOSOME RESEARCH IN CANCER THERAPY

An exosome is a small particle that is secreted by cells. Its size can range from 50 to 150 nm and has a surface consisting of proteins and lipids that originate from the cell membrane. Additionally, proteins and nucleic acids, such as DNA, microRNAs, and mRNAs, can be found inside the exosome as its “cargo.” 6 Recently, many researchers have discovered that exosomes are involved in the mechanisms of various diseases. As mentioned above, various functional compounds, such as microRNAs, mRNAs, and proteins, can be contained within exosomes. 7 , 8 Many cells use secretion of exosomes to communicate with one another, and these exosomes can even reach distant cells. Cancer cells can also secrete exosomes that contain molecules beneficial to cancer growth. For example, microRNAs found in cancer exosomes can modulate gene expression to induce angiogenesis in the tumor microenvironment, which supports metastasis. 9 Exosomes released from cancer cells can also reportedly break the blood‐brain barrier, which makes it contribute to brain metastasis. 10 , 11 Cancer cells themselves are similarly affected by the exosomes secreted by the surrounding normal cells. 12 In one case, the exosomes secreted by bone marrow‐delivered mesenchymal stem cells can force cancer cells into a dormant state. 13 These dormant cancer cells become resistant to chemotherapy and are involved in long‐term disease recurrence. Thus, exosomes are deeply involved in cancer proliferation, invasion, and metastasis, as well as in the formation of the tumor microenvironment and pre‐metastatic niche. 13 Further research on cancer‐related exosomes is ongoing.

Knowledge of exosomes can be applied to cancer treatment. If the secretion of exosomes from cancer cells can be prevented, then signal transduction supporting the formation of the tumor microenvironment and pre‐metastatic niche can be blocked. Work focusing on the removal of cancer exosomes is now ongoing. 14

Exosomes can also be utilized for cancer diagnosis. Exosomes secreted by many cell types are found in various body fluids, such as blood and urine. Capturing and analyzing exosomes from cancer cells can be used to detect the presence of disease. 15 Obtaining blood or urine from patients is not very invasive or painful. Since many molecules, such as various proteins, DNA, and microRNAs, can be found in exosomes from normal cells, it is important to distinguish them from cancer‐related ones. If exosomes are to be used for cancer diagnosis, then specific biomarkers need to be discovered. Additionally, the development of a method to detect these exosomes must be done. Currently, exosome detection methods for exosomes abundantly found in the serum of colorectal and pancreatic cancer patients, as well as exosomes found in the urine of bladder cancer patients, are being developed. 16 , 17 Thus, further understanding of the mechanisms governing cancer proliferation, invasion, and metastasis, as well as the development of cancer detection and therapeutic methods, is significantly affected by exosome research.

3. MICROBIOME IN CANCER RESEARCH

A large number of microorganisms inhabit the human body. These microorganisms include bacteria, viruses, and fungi. Among them, bacteria have the most important relationship with the human body. Bacteria can live anywhere within the human body, including the digestive tract, respiratory system, and oral cavity. 18 , 19 , 20 In particular, bacteria in the digestive tract are rich in type and number, 21 with possibly 1000 types and more than 100 trillion individual bacterial cells present. 22 , 23 The overall population of various bacteria found in the human intestine is referred to as the “intestinal flora.” Recently, the terms “microbiota” or “microbiome” have also been widely used.

Recent advancements with NGS have led to a much more precise understanding of the intestinal microbiome. 24 The bacteria in the human microbiome mainly belong to four phyla: Firmicutes, Bacteroidetes, Proteobacteria, and Actinobacteri. Of these, Firmicutes and Bacteroidetes are the most dominant species. It is reported that microbiome vary depending on age and race. 25 , 26 Dysbiosis is a condition in which the diversity of the microbiome is reduced. Dysbiosis is reportedly involved in various diseases such as inflammatory bowel disease, colorectal cancer, obesity, diabetes, and allergic diseases. 27 , 28 , 29 For example, bacteria such as Atopobium parvulum and Actinomyces odontolyticus increase in number during the early stages of colorectal cancer (adenomas or intramucosal cancers) and decrease in number during cancer progression. 30 This suggests that a specific microbiome is associated with early stages of colorectal cancer development, which may be useful knowledge for early cancer detection.

Various studies have also been conducted to elucidate the relationship between the microbiome and the human immune system. 31 The IgA antibody, which is one of the most important elements in the intestinal immune system, is believed to play a role in the elimination of pathogens and maintenance of the intestinal environment. The IgA antibody recognizes, eliminates, and neutralizes pathogenic bacteria and toxins. It also maintains a symbiotic relationship by recognizing and binding to the normal microbiome of the host. 32 Mice lacking a microbiome have reduced production of the IgA antibody. A microbiome is required for IgA antibody differentiation. Recent studies have identified W27IgA antibodies that have the ability to bind to various bacteria. 33 Oral administration of a W27IgA antibody to enteritis model mice suppressed enteritis by altering the microbiome. This W27IgA antibody can recognize a part of the amino acid sequence of serine hydroxymethyl transferase, which is a metabolic enzyme involved in bacterial growth. The W27IgA antibody can suppress the growth of E coli by binding to them. However, the W27IgA antibody does not bind to bacteria that suppress enteritis, such as bifidobacteria and lactic acid bacteria. 33 Thus, the microbiome is deeply involved in human intestinal immunity. Recently, it is having been established that the microbiome is not only involved in intestinal immunity, but also in the systemic immune system.

As the analysis of the microbiome progresses, the pathophysiology of various diseases, such as cancers, and its relationship with the regulatory function of the human immune system will be further elucidated. It has been demonstrated that F nucleatum plays a role in the development and progression of colon adenomas and colorectal cancer. It is also related to lymph node metastases and distant metastasis. 34 , 35 Also, microbiome is associated with hepatocellular carcinoma. 36 Studying microbiome will give us some clue in the development and remedy for gastrointestinal cancers (Table  1 ).

Gastrointestinal cancer and their related microbiome

4. THE RISE OF IMMUNOTHERAPY IN CANCER TREATMENT

For many years, surgery, chemotherapy, and radiation therapy were the main methods of cancer treatment. In addition to these therapies, immunotherapy has recently attracted great attention worldwide (Table  2 ). 37 , 38 Under normal circumstances, a cancer antigen will activate the patient's immune system to attack the cancer cells. However, sometimes the immune system does not recognize the cancer cells as non‐self, or it simply fails to attack them. This can result in the development and progression of cancer.

Immune checkpoint inhibitors

Although therapies that activate the immune system against cancer cells have been studied for a long time, the use of the patient's own immune system for cancer treatment was not established. Recently, the effectiveness of both immune checkpoint inhibition therapy and chimeric antigen receptor (CAR)‐T cell therapy has proved to be promising. 39 , 40 Immunotherapy has moved to the forefront of cancer treatment strategies.

There are two major reasons why proving the efficacy of cancer immunotherapies was difficult for some time. First, cancer immunity is strongly suppressed. Signal transduction from immune checkpoint compounds, such as PD‐1 and CTLA4, strongly inhibits cytotoxic T cells (CTLs). 38 This checkpoint mechanism can prevent the immune system from attacking cancer cells. The development of immune checkpoint inhibitors has arisen from the discovery of this mechanism. Inhibition of immune checkpoint molecules with neutralizing antibodies can release the suppression of cancer‐specific CTLs, activate immunity, and promote cancer elimination. The effectiveness of immune checkpoint antibodies has been confirmed and clinically applied to many solid cancers such as melanoma, 41 lung cancer, 42 urothelial cancer, 43 gastric cancer, 44 and esophageal cancer. 45 In addition to PD‐1 and CTLA4, new immune checkpoint molecules, such as LAG3, TIGIT, and SIRPA, are also being actively studied. 46 , 47 , 48 Although this therapy is promising, the cancer cases who respond to these therapies are limited. This is because use of this therapy requires the presence of cancer‐specific CTLs in the patient's body. To maximize the therapeutic effect, it is desirable to select appropriate cases and develop useful biomarkers.

The second difficulty for immunotherapy is that T cells do not recognize specific cancer cell antigens and immune accelerators are too weak. One goal of CAR‐T cell therapy is to strengthen the immune accelerator by administering CTLs to the patient's body that recognize specific cancer cell‐specific antigens. A CAR is prepared by fusing a single chain Fv (scFv), derived from a monoclonal antibody that recognizes a specific antigen expressed by cancer cells, with CD3z and costimulatory molecules (CD28, 4‐1BB, and others). Next, the CAR is introduced to the T cells obtained from a cancer patient and CAR‐T cells are made. CAR‐T cells recognize the specific antigen of the cancer cells and are activated to damage these cells. CAR‐T cells recognize cancer‐specific antigens with high antibody specificity and attack the respective cancer cells with strong cytotoxic activity and high proliferative activity. CAR‐T therapy is effective in blood cancers such as B‐cell acute lymphoblastic leukemia and myeloma. 49 , 50 While CAR‐T cell therapy has a high therapeutic effect, a frequent and serious adverse event called cytokine release syndrome has been observed in some patients. 51 , 52 The development of a technique for suppressing the occurrence of cytokine release syndrome is anticipated. In addition, the development of CAR‐T cell therapies for solid tumors is ongoing.

Recently, there was new progress made in treating gastrointestinal cancer patients. For MSI‐H colorectal cancer, the combination therapy with nivolumab and ipilimumab was approved. From the nivolumab plus ipilimumab cohort of CheckMate‐142, progression‐free survival rates were 76% (9 months) and 71% (12 months); respective overall survival rates were 87% and 85% which were quite high. This new treatment will benefit MSI‐H colorectal cancer patients. 53

Thus, it is expected that further understanding of cancer immune mechanisms and the development of various immunotherapies will contribute to great progress in cancer treatment.

One problem for immunotherapy is that there is no certain predictive biomarker. It was thought that the expression of PD‐1 or PD‐L1 would predict the effect. However, this was not the case. To find a new biomarker, we assessed the cytolytic activity (CYT) score. The CYT score is a new index of cancer immunity calculated from the mRNA expression levels of GZMA and PRF1. We are now evaluating CYT score in gastric cancer patients (data not published). The development in the biomarker search will benefit many gastrointestinal cancer patients.

5. ADVANTAGES FOR USING ORGANOIDS IN CANCER RESEARCH

The three‐dimensional (3D) organoid system is a cell culture‐based, novel, and physiologically relevant biologic platform. 54 An organoid is a miniaturized and simplified version of an organ that is produced in vitro in 3D and shows realistic microanatomy. With only one to a few cells isolated from tissue or cultured cells as the starting material, organoids are grown and passaged in a basement membrane matrix, which contributes to their self‐renewal and differentiation capacities. 54 , 55 The technique used for growing organoids has rapidly improved since the early 2010s with the advent of the field of stem cell biology. The characteristics of stem, embryonic stem cells (ES cells), or induced pluripotent stem cells (iPS cells) that allow them to form an organoid in vitro are also found in multiple types of carcinoma tissues and cells. Therefore, cancer researchers have applied ES cells or iPS cells in their field. 56 , 57 , 58

Organoid formation generally requires culturing stem cells or their progenitor cells in 3D. 54 , 55 The morphological and functional characteristics of various types of carcinoma tissue have been recapitulated in organoids that were generated from single‐cell suspensions or cell aggregates. These suspensions or aggregates were isolated from murine and human tissues or cultured cells, as well as from cancer stem cells propagated in culture. The structures of the organoids show the potential of cancer stem cell self‐renewal, proliferation, and differentiation abilities, and also provide insights into the roles of molecular pathways and niche factors that are essential in cancer tissues. 56 , 57 , 59 , 60 , 61 , 62 The organoid system also has been utilized for studying multiple biological processes, including motility, stress response, cell‐cell communications, and cellular interactions that involve a variety of cell types such as fibroblasts, endothelial cells, and inflammatory cells. These interactions are mediated via cell surface molecules, extracellular matrix proteins, and receptors in the microenvironment under homeostatic and pathologic conditions.

Although the organoid system is a complex and not effortless procedure that requires specific media, supplements, and many tricky techniques, 58 , 63 application of this system has been extended to a variety of cell types from different carcinomas (colorectal, pancreatic, prostate, breast, ovary, and esophageal cancers). 56 , 57 , 59 , 60 , 61 An organoid is generally induced within a few days to weeks, and is faster and less costly than the murine xenograft assay. Furthermore, applying novel genetic manipulations (e.g. CRISPR‐Cas9) can be carried out in the organoid system. 64 , 65

Kasagi et al modified keratinocyte serum‐free medium to grow 3D organoids from endoscopic esophageal biopsies, immortalized human esophageal epithelial cells, and murine esophagi. Esophageal 3D organoids serve as a novel platform to investigate regulatory mechanisms in squamous epithelial homeostasis in the context of esophageal cancers. 64

We anticipate that many experimental results that utilize the organoid system will be published in the future.

The 3D organoid system has emerged in the past several years as a robust tool in basic research with the potential to be used for personalized medicine. 66 By passaging dissociated primary structures to generate secondary 3D organoids, this system can be performed using live tissue pieces obtained from biopsies, operative‐resected specimens, or even frozen tissues. This method has the potential to transform personalized therapy. For example, in the case of cancer recurrence, an effective chemotherapy can be selected by testing the chemotherapeutic sensitivity of cancer‐derived organoids from an individual patient's tissue stocks. In many cases, a patient's organoid accumulation is helpful for testing the sensitivity of novel therapeutic agents for treating carcinoma. 66 Hence, it appears that organoid biology will further develop with a goal of translating the research into personalized therapy.

6. SUMMARY AND FUTURE DIRECTIONS

This review describes four new cancer‐related studies: exosomes, microbiome, immunotherapy, and organoids (Figure  1 ).

The summary of the four cancer research areas. In this figure the summary of the four cancer research areas is shown: exosome, microbiome, immunotherapy, and organoid research

Since exosomes are released in blood or urine, if the capturing system is established, it will be a less invasive test to diagnose cancer. In the present, the presence of circulating tumor DNA (ctDNA) is one of the tools to detect the minimal residual disease. However, since ctDNA is only DNA, it is difficult to spread to cancer research. In that respect, as exosomes include not only DNA but also other nucleic acids and proteins, this will be a new tool for cancer research such as the diagnosis of early cancer.

Microbiome may lead to improved cancer diagnosis and treatment. Detecting a specific microbiome in a gastrointestinal tract may predict a specific cancer. And changing microbiome in some way may result in preventing cancer development.

Organoids may help address the problem of drug resistance, and also lead to the development of personalized therapy. However, producing organoids takes time and testing the drug resistance may take more time. If we could overcome these problems, the research into organoids can contribute to overcoming cancer.

As shown in Table  3 , many new studies and findings are reported into this field of research. These four novel cancer research areas will make many contributions to the diagnosis and treatment of cancer.

Recent studies on exosome, microbiome, immunotherapy, and organoids

Conflict of Interest: All the authors have no conflict of interest to disclose.

ACKNOWLEDGMENTS

We thank Dr Hirofumi Hasuda and Dr Naomichi Koga for their help in preparing this manuscript. We also thank J. Iacona, PhD, from Edanz Group for editing a draft of this manuscript.

Ando K, Hu Q, Kasagi Y, Oki E, Mori M. Recent developments in cancer research: Expectations for a new remedy . Ann Gastroenterol Surg . 2021; 5 :419–426. 10.1002/ags3.12440 [ PMC free article ] [ PubMed ] [ CrossRef ] [ Google Scholar ]

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Title: ferret-ui: grounded mobile ui understanding with multimodal llms.

Abstract: Recent advancements in multimodal large language models (MLLMs) have been noteworthy, yet, these general-domain MLLMs often fall short in their ability to comprehend and interact effectively with user interface (UI) screens. In this paper, we present Ferret-UI, a new MLLM tailored for enhanced understanding of mobile UI screens, equipped with referring, grounding, and reasoning capabilities. Given that UI screens typically exhibit a more elongated aspect ratio and contain smaller objects of interest (e.g., icons, texts) than natural images, we incorporate "any resolution" on top of Ferret to magnify details and leverage enhanced visual features. Specifically, each screen is divided into 2 sub-images based on the original aspect ratio (i.e., horizontal division for portrait screens and vertical division for landscape screens). Both sub-images are encoded separately before being sent to LLMs. We meticulously gather training samples from an extensive range of elementary UI tasks, such as icon recognition, find text, and widget listing. These samples are formatted for instruction-following with region annotations to facilitate precise referring and grounding. To augment the model's reasoning ability, we further compile a dataset for advanced tasks, including detailed description, perception/interaction conversations, and function inference. After training on the curated datasets, Ferret-UI exhibits outstanding comprehension of UI screens and the capability to execute open-ended instructions. For model evaluation, we establish a comprehensive benchmark encompassing all the aforementioned tasks. Ferret-UI excels not only beyond most open-source UI MLLMs, but also surpasses GPT-4V on all the elementary UI tasks.

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A new way to detect radiation involving cheap ceramics

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The radiation detectors used today for applications like inspecting cargo ships for smuggled nuclear materials are expensive and cannot operate in harsh environments, among other disadvantages. Now, in work funded largely by the U.S. Department of Homeland Security with early support from the U.S. Department of Energy, MIT engineers have demonstrated a fundamentally new way to detect radiation that could allow much cheaper detectors and a plethora of new applications.

They are working with Radiation Monitoring Devices , a company in Watertown, Massachusetts, to transfer the research as quickly as possible into detector products.

In a 2022 paper in Nature Materials , many of the same engineers reported for the first time how ultraviolet light can significantly improve the performance of fuel cells and other devices based on the movement of charged atoms, rather than those atoms’ constituent electrons.

In the current work, published recently in Advanced Materials , the team shows that the same concept can be extended to a new application: the detection of gamma rays emitted by the radioactive decay of nuclear materials.

“Our approach involves materials and mechanisms very different than those in presently used detectors, with potentially enormous benefits in terms of reduced cost, ability to operate under harsh conditions, and simplified processing,” says Harry L. Tuller, the R.P. Simmons Professor of Ceramics and Electronic Materials in MIT’s Department of Materials Science and Engineering (DMSE).

Tuller leads the work with key collaborators Jennifer L. M. Rupp, a former associate professor of materials science and engineering at MIT who is now a professor of electrochemical materials at Technical University Munich in Germany, and Ju Li, the Battelle Energy Alliance Professor in Nuclear Engineering and a professor of materials science and engineering. All are also affiliated with MIT’s Materials Research Laboratory

“After learning the Nature Materials work, I realized the same underlying principle should work for gamma-ray detection — in fact, may work even better than [UV] light because gamma rays are more penetrating — and proposed some experiments to Harry and Jennifer,” says Li.

Says Rupp, “Employing shorter-range gamma rays enable [us] to extend the opto-ionic to a radio-ionic effect by modulating ionic carriers and defects at material interfaces by photogenerated electronic ones.”

Other authors of the Advanced Materials paper are first author Thomas Defferriere, a DMSE postdoc, and Ahmed Sami Helal, a postdoc in MIT’s Department of Nuclear Science and Engineering.

Modifying barriers

Charge can be carried through a material in different ways. We are most familiar with the charge that is carried by the electrons that help make up an atom. Common applications include solar cells. But there are many devices — like fuel cells and lithium batteries — that depend on the motion of the charged atoms, or ions, themselves rather than just their electrons.

The materials behind applications based on the movement of ions, known as solid electrolytes, are ceramics. Ceramics, in turn, are composed of tiny crystallite grains that are compacted and fired at high temperatures to form a dense structure. The problem is that ions traveling through the material are often stymied at the boundaries between the grains.

In their 2022 paper, the MIT team showed that ultraviolet (UV) light shone on a solid electrolyte essentially causes electronic perturbations at the grain boundaries that ultimately lower the barrier that ions encounter at those boundaries. The result: “We were able to enhance the flow of the ions by a factor of three,” says Tuller, making for a much more efficient system.

Vast potential

At the time, the team was excited about the potential of applying what they’d found to different systems. In the 2022 work, the team used UV light, which is quickly absorbed very near the surface of a material. As a result, that specific technique is only effective in thin films of materials. (Fortunately, many applications of solid electrolytes involve thin films.)

Light can be thought of as particles — photons — with different wavelengths and energies. These range from very low-energy radio waves to the very high-energy gamma rays emitted by the radioactive decay of nuclear materials. Visible light — and UV light — are of intermediate energies, and fit between the two extremes.

The MIT technique reported in 2022 worked with UV light. Would it work with other wavelengths of light, potentially opening up new applications? Yes, the team found. In the current paper they show that gamma rays also modify the grain boundaries resulting in a faster flow of ions that, in turn, can be easily detected. And because the high-energy gamma rays penetrate much more deeply than UV light, “this extends the work to inexpensive bulk ceramics in addition to thin films,” says Tuller. It also allows a new application: an alternative approach to detecting nuclear materials.

Today’s state-of-the-art radiation detectors depend on a completely different mechanism than the one identified in the MIT work. They rely on signals derived from electrons and their counterparts, holes, rather than ions. But these electronic charge carriers must move comparatively great distances to the electrodes that “capture” them to create a signal. And along the way, they can be easily lost as they, for example, hit imperfections in a material. That’s why today’s detectors are made with extremely pure single crystals of material that allow an unimpeded path. They can be made with only certain materials and are difficult to process, making them expensive and hard to scale into large devices.

Using imperfections

In contrast, the new technique works because of the imperfections — grains — in the material. “The difference is that we rely on ionic currents being modulated at grain boundaries versus the state-of-the-art that relies on collecting electronic carriers from long distances,” Defferriere says.

Says Rupp, “It is remarkable that the bulk ‘grains’ of the ceramic materials tested revealed high stabilities of the chemistry and structure towards gamma rays, and solely the grain boundary regions reacted in charge redistribution of majority and minority carriers and defects.”

Comments Li, “This radiation-ionic effect is distinct from the conventional mechanisms for radiation detection where electrons or photons are collected. Here, the ionic current is being collected.”

Igor Lubomirsky, a professor in the Department of Materials and Interfaces at the Weizmann Institute of Science, Israel, who was not involved in the current work, says, “I found the approach followed by the MIT group in utilizing polycrystalline oxygen ion conductors very fruitful given the [materials’] promise for providing reliable operation under irradiation under the harsh conditions expected in nuclear reactors where such detectors often suffer from fatigue and aging. [They also] benefit from much-reduced fabrication costs.”

As a result, the MIT engineers are hopeful that their work could result in new, less expensive detectors. For example, they envision trucks loaded with cargo from container ships driving through a structure that has detectors on both sides as they leave a port. “Ideally, you’d have either an array of detectors or a very large detector, and that’s where [today’s detectors] really don’t scale very well,” Tuller says.

Another potential application involves accessing geothermal energy, or the extreme heat below our feet that is being explored as a carbon-free alternative to fossil fuels. Ceramic sensors at the ends of drill bits could detect pockets of heat — radiation — to drill toward. Ceramics can easily withstand extreme temperatures of more than 800 degrees Fahrenheit and the extreme pressures found deep below the Earth’s surface.

The team is excited about additional applications for their work. “This was a demonstration of principle with just one material,” says Tuller, “but there are thousands of other materials good at conducting ions.”

Concludes Defferriere: “It’s the start of a journey on the development of the technology, so there’s a lot to do and a lot to discover.”

This work is currently supported by the U.S. Department of Homeland Security, Countering Weapons of Mass Destruction Office. This support does not constitute an express or implied endorsement on the part of the government. It was also funded by the U.S. Defense Threat Reduction Agency.

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Scientists around the world make use of the observations collected from NASA's heliophysics missions to study space around Earth, around the Sun and throughout the solar system.

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I previously wrote about the importance of attracting public attention to scientific research . In today’s world, where billions of people are attached to their digital devices watching the very addictive but often useless TikTok content or receiving instant gratification by engaging in meaningless debates about celebrities, scientists need to find creative ways to have their research noticed. Popularizing scientific research helps inspire the younger generations to go into science and provide the general public with a sense of optimism enabling the government to channel more resources into science. People do need inspiration. But very often, even very important scientific breakthroughs requiring many years, hard work, skill, funding, and genuine serendipity go largely unnoticed by the general public.

One of the best ways to measure expert and public attention is the cumulative Altmetric Attention Score , originally developed by Digital Science and adopted by many prestigious publishers, including Nature Publishing Group. Every Nature paper and the papers published by pretty much every credible publisher are tracked by Digital Science by the Document Object Identification (DOI) or the Unique Resource Locator (URL) . While Altmetric has many limitations, for example, it does not track LinkedIn posts and may not adequately cover the impact of top-tier media coverage, at the moment it is the blueprint for tracking attention.

Altmetric Score in The Age of Generative AI

Media attention is likely to be very important in the age of generative AI. Many modern generative systems, such as ChatGPT, Claude, Mistral, and Gemini, as well as hundreds of Large Language Models (LLMs) in China, use the data from the same sources referenced in Altmetric to learn. The more times generative systems see the same concept presented in different contexts, the better they learn. So if you want to contribute to the training of AI systems that may thank you for it in the future - Altmetric is the way to go.

So what can a research group do to ensure they are communicating their findings effectively and increasing the visibility of their research to ensure it gets reflected in the Altmetric Attention Score?

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Altmetric openly discloses the weights of the various sources and the scoring algorithm is relatively straightforward. It is easy to learn, and there are multiple online resources providing advice on how to share your research in ways that will be captured by Altmetric. Cambridge University Press published a guideline to Altmetric for the authors on how to popularize their research with Altmetric in mind. Wolters Kluwer put out a guide and the editor of Toxicology and Pathology wrote a comprehensive overview of Altmetric and how to use it. Surprisingly, this overview got an Altmetric Attention Score of only 4 at the time of the writing, but was cited 137 times according to Google Scholar .

Altmetric monitors social networks, including X (formerly Twitter), Facebook, and Reddit; all major top-tier mainstream media, mainstream science blogs, policy documents, patents, Wikipedia articles, peer review websites, F1000, Syllabi, X (formerly Twitter), tracked Facebook pages, Reddit, one of the Stack Exchange sites, and Youtube. Unfortunately, several powerful platforms, including LinkedIn, are not currently tracked.

The popularity of the paper depends on many factors. Firstly, it has to be novel, trendy, and newsworthy. You are unlikely to get high Altmetric Score with a boring topic. Secondly, papers coming out of popular labs in top-tier academic institutions and in top journals are likely to attract more attention. Often, the communications officers in these academic institutions work closely with the media to amplify notable research. Celebrity companies, for example, Google DeepMind, consistently get higher coverage.

Screenshot of the Altmetric Attention Score "Flower" showing several tracked sources

Here are the five tips for increasing the visibility of your work and ensuring that reach is tracked and reflected by Altmetric:

1. Understand How Altmetric System Works

Congratulations, if you read this article and looked at what sources are tracked by Altmetric. Most likely, you got the basics and will be able to get a “balanced flower” by making a press release, tweeting the DOI of the paper on X, posting a video overview of your paper on Youtube, announcing on Reddit (I still need to learn how to do this).

To understand how Altmetric works, I emailed a few questions to Miguel Garcia, Director of Product and Data Analytics Hub at Digital Science and my first question was wether the Altmetric algorithm is open source. “The Altmetric Attention Score's calculation is not open source but we try to provide as much information as possible around how we calculate it here, and are currently considering what steps we might take to make our algorithms more transparent.” He also provided a link to how the Altmetric Attention Score is calculated.

Many professionals use LinkedIn as the primary social media resource and I was wondering why Altmetric stopped tracking it. Bad news - technical reasons prevent tracking DOIs on LinkedIn. Good news - they are actively seeking ways to appropriately track mentions on LinkedIn and we may see some news toward the end of the year.

My other big question was how does Altmetric count tweets and retweets on X. What if there are many posts from the same account? Miguel’s response was: “Re-tweets count less than original tweets. In addition to that, modifiers are applied to the type of account that is tweeting in order to reduce the weight of the tweet in situations where we find signals of bias or promiscuity (for example a journal publisher only tweeting their own articles). Besides that, we have conditions around the maximum number of retweets in order to limit the maximum impact they would have.”

So tweeting the article many times will not help you. But if other scientists tweet you paper with a DOI - these tweets will get counted. So tweet others as you would like to be tweeted.

2. Make a Press Release and Distribute to Science-focused Media

If your paper is significant, for example, you elucidated novel disease biology, discovered a new drug, developed a new fancy algorithm, designed a new material, or developed a new application for a quantum computer, it is worthwhile investing some time and resources in writing a press release. If you are working for an academic institution, most likely they have a communications office that will help you. If you do not have this luxury, you will need to learn how to write a press release. Plenty of free online guides cover the basics of press release writing. And press releases are one area where ChatGPT and other generative tools do surprisingly well. Upload your paper and ask it to write a press release, check for errors or exaggerations, edit, and you are ready to go. Just make sure to include the DOI and the URL of your paper. A proper business press release on BusinessWire or PRNewswire may cost several thousand dollars. In my opinion, these resources are dramatically overcharging while providing little service. I don't remember a case where a journalist picked up our news based on a commercial press release. But these releases are often reposted by other online press release distributors and the boost to Altmetric may be considerable. The default news release distribution service for research news is EurekAlert. This resource may sometimes result in journalistic coverage as many reporters are using it for science news. There are many free resources you can use if you do not have any budget.

Once the press release is issued, share it with the media. Share the resulting news coverage via your social networks and contacts. Many journalists track the popularity of their news articles and giving them several thousand extra views from professional audience and increasing their social following increases the chances that they will cover the next important research paper.

3. Make a Blog Post

Writing a blog post can be longer and more comprehensive than the press release. Make sure to add fancy diagrams and graphical explainers. You can share the blog post with the journalists at the same time as the press release. Your blog may serve as a source of inspiration for third party news coverage. Make sure to reference the DOI and URL of your paper.

If your paper is in one of the Nature journals, consider writing a “Behind the Paper" blog post on Nature Bioengineering Community. Surprisingly, these blogs are rarely picked up by Altmetric but may serve as a source of inspiration for the journalists and social media influencers. Plus, it is a resource by the Nature Publishing Group.

4. Tweet and Ask Your Team Members to Tweet

Each post on X gives you a quarter of an Altmetric point. If your paper goes viral on X, your Altmetric score can be considerable. Plus, once journalists notice that it went viral, they will be more likely to cover the story, further increasing the score.

Try to choose the time of the post, the hashtags, and the images wisely. Since Elon Musk took over X and opened the algorithm it became very transparent and easy to optimize for. Here are the top 10 tips for boosting attention for a post on X. Make sure to include the DOI or the URL of the paper for Altmetric to find the post.

5. Experiment, Learn, Repeat

My highest Altmetric Attention Score core to date was around 1,500 for a paper in Nature Biotechnology published in 2019, where we used a novel method for designing small molecules called Generative Tensorial Reinforcement Learning (GENTRL) to generate new molecules with druglike properties that got synthesized and tested all the way into mice. In 2024, we went further and showed that an AI-generated molecule for an AI-discovered target was tested all the way up to Phase II human trials, but the paper published in Nature Biotechnology, let’s call it the TNIK paper , has achieved a score ofjust over 600 to date. So what has changed and what can we learn from these two papers?

The popularity of the paper depends on many factors. Ones which capture the public imagination or have widespread appeal are of course, much more likely to gain traction online. When we published the GENTRL paper in 2019, Generative AI was in its infancy, and there are pretty much no other companies that I heard of at the intersection of generative AI and drug discovery. We also published multiple articles in this field in the years leading to that paper and many key opinion leaders (KOLs) followed us. That following included a small army of generative AI skeptics who not only contributed to multiple rejections in peer-reviewed journals but also openly criticized this approach in social networks. This criticism also helped boost the Altmetric Score and bring more attention to the study. So first learning from this exercise - negative publicity helps overall publicity. As long as you are certain that your research results are honest - leave room for criticism and even help expose your paper’s weaknesses. Critics are your greatest Altmetric boosters. Since readers and, by extension journalists, react to negative news and drama stronger than to positive news, critical reviews will boost your Altmetric as long as the DOI or URL of the paper is properly referenced.

Secondly, papers coming out of popular labs in top-tier academic institutions and in top journals are likely to attract more attention. Often, the communications officers in these academic institutions work closely with the media to amplify notable research. Celebrity companies, for example, Google DeepMind, always get a higher level of coverage. For example, the AlphaFold paper published in July 2021 in Nature got an Altmetric Attention Score of over 3,500 . Even though I have not seen any drugs out of AlphaFold reaching preclinical candidate status, I predict the popularity of this tool will result in the first Nobel Prize in this area. Therefore, in order to become famous and popularize your research more effectively, it is a good idea to build up the public profile of yourself and your work. For example, Kardashians are famous for being famous .

Be careful with Wikipedia. I made a mistake explaining the importance of Wikipedia to students when lecturing on the future of generative AI, and one or two of them got banned for expanding the articles with paper references. Wikipedia requires that these are added by independent editors rather than the authors of papers themselves, but if some editors do not like it, they will not go deep or investigate - they will assume wrongdoing. So it is better to avoid even talking about Wikipedia. References there should happen naturally and often some of the more popular papers get picked up and referenced by veteran editors.

Experimenting with Altmetric will also help you explore new strategies for popularizing scientific research and develop new strategies for inspiring people to learn or even get into the new exciting field. UNESCO estimates that there was just over 8 million full-time equivalent (FTE) researchers in 2018 globally. Only a fraction of these are in biotechnology - less than 0.01% of the global population. If you motivate a million students to go into biotechnology by popularizing your research, you double this number.

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