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Biochemistry Theses and Dissertations

This collection contains theses and dissertations from the Department of Biochemistry, collected from the Scholarship@Western Electronic Thesis and Dissertation Repository

Theses/Dissertations from 2024 2024

Elucidating the temporal regulation of protein kinase CK2 by the peptidyl-prolyl isomerase Pin1 , Scott E. Roffey

Theses/Dissertations from 2023 2023

Genetic Tools Towards A Synthetic Biology Approach For Whole Mitochondrial Genome Engineering , Ryan R. Cochrane

Characterization of DNA Regulatory Elements of the Highly Abundant Secreted Protein 1 (HASP1) Promoter and Analysis of Transcriptomic Responses Under Phosphate Depletion in the Diatom Phaeodactylum tricornutum , Mahsa Farmanbar

Multi-omics analysis of epithelial ovarian cancer metastasis , Mallory I. Frederick

Functionalizing conjugative systems to deliver CRISPR nucleases for targeted bacterial killing , Thomas A. Hamilton

Characterizing SaCas9 and SaCas9[D10E] tolerance to mismatches using Directed Evolution Using Fluorescence Activated Cell Sorting (DEUFACS) , Olha Haydaychuk

Selective Activation of Thrombin Activatable Fibrinolysis Inhibitor (TAFI) Attenuates Metastatic and Angiogenic Capabilities of Melanoma and Lung Carcinoma in vitro , Jacklyn Krizsan

The inner workings of thrombin-activatable fibrinolysis inhibitor: a study of the TM-mediated activation of TAFI and inactivation of TAFIa , Haley D N Marier

Advances in Phaeodactylum tricornutum nuclear engineering , Mark Pampuch

Developing Regulated CRISPR Systems to Control Bacterial Microbiomes , Gregory M. Pellegrino

State-of-the-art Approaches for Sequencing, Assembling and Annotating Naphthenic Acid Degrading Bacterial Metagenomes , Henry H. Say

Mechanism of Permissive Cleavage Activity of TevCas12a , Alexa White

Acetylation regulates Thioredoxin Reductase activity and oligomerization , DAVID E. WRIGHT

Kinetic Analyses of SaCas9[D10E] in vitro , Claire Zhang

Theses/Dissertations from 2022 2022

The development of Sinorhizobium meliloti and Deinococcus radiodurans as chassis for synthetic biology applications , Stephanie L. Brumwell

Applications of nanopore DNA sequencing for improved genome assembly , Daniel Giguere

Dual Functions of Interstrand Crosslink Repair Nuclease SNM1A , Ryan Grainger

Probing the genetic code with Leucine tRNA variants , Peter Anderson Hall

Perseverance of protein homeostasis despite mistranslation , Farah Hasan

Towards more complete metagenomic analyses through circularized genomes and conjugative elements , Benjamin R. Joris

Dissecting the Molecular Basis of NRF2 Activity Modulation in the Oxidative Stress Response , Nadun Karunatilleke

Chromatin regulation by RB-interacting proteins in cellular immune functions , Seung June Kim

Identification and characterization of novel fumonisin-detoxifying enzymes , Michael C. Kovacevic

Kinetic and structural influences of acetylation on ubiquitin processing , Rachel E. Lacoursiere

Illuminating Transfer RNA Variants as Genetic Modifiers in Models of Human Disease , Jeremy T. Lant

RHAMM as a biomarker and therapeutic target in triple-negative breast cancer , Britney Messam

Characterization of disease-causing HARS mutations , Yi Qiu

Global Regulation of miRNA and mRNA Homeostasis by Terminal Uridylyltransferases TENT3A/B , Pengcheng Zhang

Theses/Dissertations from 2021 2021

Mapping Ku70 Protein Interactions Using Proximity-Dependent Biotin Identification , Sanna Abbasi

Applications of Genetic Testing for Endocrine and Metabolic Disorders , Amanda Berberich

Implications and Applications of Transfer RNA Variants that Mistranslate the Genetic Code , Matthew D. Berg

Biochemical and biophysical characterization of a novel fumonisin detoxifying enzyme from Aspergillus niger , Shane G. Butler

Elucidating the Structural and Dynamical Properties of the Intrinsically Disordered Protein Nrf2 Using Molecular Dynamics Simulations , Megan Nicole Chang

Investigating The Role Of PKC And Its Mechanisms In Regulation Of IGF-I Bioavailability In Fetal Growth Restriction , Allan W. Chen

The Genetic Landscape of Neurodegenerative and Cerebrovascular Disease Phenotypes. , Allison A. Dilliott

New Perspectives on Phosphorylation State in the Parkin Ubiquitination Cascade , Karen Dunkerley

The study of the structure and dynamics of parkin activation , Elaine Aisha Freeman

Development of 3D Bioartificial Human Tissue Models of Periprosthetic Shoulder Joint Infection , Tony B. Huang

tRNA Regulation in Humans: The cellular effect of a pathological HARS Y454S mutation , Rosan Kenana

Genetic Approaches for the Study of Complex Human Diseases , Julieta Lazarte

Uncovering the ubiquitin ligase activity and substrates of the human C-terminal to LisH (CTLH) complex , Matthew E.R. Maitland

Characterizing the Role of TDG in FXR-dependent Signaling , Oladapo A. Onabote

Functional Role of DREAM and DYRK1A in High-Grade Serous Ovarian Cancer Cell Dormancy , Pirunthan Perampalam

Disruption of Insertion Sequence 200 (IS200) leads to a premature induction of the Cysteine regulon in Salmonella Typhimurium , Naomi-Jean Q. Scherba

A Characterization of RGNEF Biophysical Properties and Interactome , Brooke E. Wile

Theses/Dissertations from 2020 2020

Nutrient Sensing Pathways Mediating IGFBP1 Phosphorylation in FGR , Shapnil Bhuiyan

The Genetic Determinants of Complex Lipid and Lipoprotein Phenotypes , Jacqueline S. Dron

Development of a Thermosensitive Endonuclease to Act as a Plasmid Kill-Switch , Christopher D. Leichthammer

AWT1 is Constantly Expressed in Palmar Fascia Fibrosis and Promotes a Pro-Inflammatory Milieu , Johnny Luo

Practical Applications and Future Directions of Genetic Code Expansion: Validation of Novel Akt1 Substrates and the Design of a Synthetic Auxotroph Strain of B. subtilis , McShane M. McKenna

Deciphering the CK2-dependent phosphoproteome and its integration with regulatory PTM networks , Teresa Nunez de Villavicencio Diaz

Generation of Conditional Ku70 Knockouts in Human Cell Lines Using CRISPR/Cas9 and Dual-Nuclease CRISPR/TevCas9 , Gursimran Parmar

Thyroxine-Dependent and -Independent Effects on Premature Aging and Myelination in ATRX Mutant Mice , Megan E. Rowland

Development of the Model Marine Diatom Phaeodactylum tricornutum for Synthetic Biology Applications , Samuel S. Slattery

The role of Heat Shock Protein 90 in the Keap1/Nrf2 Mediated Oxidative-Stress Response , Zheng Song

Structural Study of the Complex Between DNA Polymerase Iota and Ub-PCNA , Harrison Taylor

Quinone Reductase 2 Roles in Proteomic Regulation and Response to Treatment with Clinical Drugs , Matthew D. Walker

Calcium signaling and pathogenesis of dysferlin C2 domains , Yuning Wang

Determining Whether the Nature of the Amino Acid Substitution or the Extent of Mistranslation Affects the Impact of Mistranslating tRNAs in Saccharomyces cerevisiae. , Yanrui Zhu

Theses/Dissertations from 2019 2019

Placental MicroRNA Expression in Pregnancies Complicated with Preeclampsia and Intrauterine Growth Restriction , Zain Awamleh

Differentially activating the oncogenic kinase Akt1 , Nileeka Balasuriya

Regulation of RNA stability by terminal nucleotidyltransferases , Christina Z. Chung

The Characterization of the Rat Bone Sialoprotein Knockout Phenotype , Benjamin Harvey

Improving the genetic diagnosis of familial hypercholesterolemia , Michael Iacocca

High Molecular-Weight Hyaluronan Prevents Basal Cell Carcinoma Via Promoting Apoptosis In Cancer-Initiating Adult Stem Cells , Violet Liu

Applications of Phosphotyrosine Superbinding SH2 Domain Variants , Xuguang Liu

Functional investigation of the role of the retinoblastoma protein in genome stability , Aren E. Marshall

Structure and Function of Stomatin-like Protein 2 , Safee Mian

Nobiletin Corrects Intestinal Insulin Resistance and Lipid Metabolism in Ldlr-/- Mice Fed a High-fat Diet , Nadya Morrow

Systematic identification of the lysine methylome using methyllysine binding domains , Wen Qin

Investigating the Role of ATRX in Glutamatergic Hippocampal Neurons , Renee Tamming

Structural and Functional Characterization of Deinococcal DNA Damage Response A (DdrA) , Filip Todorovic

Parkin Structural Perturbations in Oxidative Stress , An Tran

Mass Spectrometry-Based Proteomics Analysis Of Bioactive Proteins In EMD That Modulate Adhesion Of Gingival Fibroblast To Improve Bio-Integration Of Dental Implants , David Zuanazzi Machado Jr

Theses/Dissertations from 2018 2018

Attenuation of Obesity, Hepatic Steatosis and Reversal of Atherosclerosis by the Flavonoids Naringenin and Nobiletin , Amy C. Burke

Regulation of Beta-Catenin by the CTLH Complex , Christopher Chiasson

Conformational Arrangements of UbcH7-Ubiquitin with OspG and Parkin , Tara E. C. Condos

Chromatin organizer CTCF in brain development and behaviour , Adrienne Elbert

Characterizing the Role of Thymine DNA Glycosylase in Transcriptional Regulation and Cancer In Vivo , Mohammad Haider Hassan

Genetic determinants underlying rare diseases identified using next-generation sequencing technologies , Rosettia Ho

The Role of Thymine-DNA Glycosylase In Transcriptional Regulation , Bart Kolendowski

Metabolic and Expression Changes Associated with a Mouse Model of Intrauterine Growth Restriction (IUGR) , Bethany N. Radford

The Functional Characterization of the N-terminal Domains of TUT4 , Lauren E. Seidl

Theses/Dissertations from 2017 2017

Autoinhibition and Activation of Parkin , Jacob D. Aguirre

Characterizing the Cofactor Specificity of NQO2 , Shahed Al Massri

Role of High Molecular Weight Hyaluronan in Ultraviolet B Light-Induced Transformation , Katelyn Cousteils

An Investigation of the CK2-dependent Phosphoproteome using Inhibitor Refractory CK2-alpha , Edward Cruise

Identification of novel binding partners and substrates of histone H3K4 specific demethylase KDM5B/JARID1B , Qi Fang

Effect on Pellicle Proteome upon Adsorption of Salivary Peptide on Hydroxyapatite and their effects on Enamel Demineralization , Rajesh Kr. Gupta

Tti2 in PIKK Biosynthesis and Its Use in Identifying Missense Suppressor tRNAs , Kyle S. Hoffman

The CDK-resistant pRB-E2F1 complex recruits chromatin-organizing proteins to repetitive DNA sequences , Charles A. Ishak

Proteomic Characterization of Human Multipotent Stromal Cells Secreted Proteins with Therapeutic Potential for β-cell Regeneration , Miljan Kuljanin

Coevolving Residues and the Expansion of Substrate Permissibility in LAGLIDADG Homing Endonucleases , Thomas A. McMurrough

Regulation of C-RAF stability by the RanBPM/CTLH complex , Christina J. McTavish

Quantitative Proteomic Characterization of CX-4945, a Clinical Stage Inhibitor of Protein Kinase CK2 , Adam J. Rabalski

Investigating E2F independent cell cycle control and tumor suppression by pRB , Michael J. Thwaites

An invasive tumor cell subpopulation as a therapeutic target in breast cancer , Tahereh Vakili

Assessing the role of Ku70 vWA domain phosphorylation in the inhibition of Aurora B and activation of the DNA damage response , Elizabeth A. Walden

Structural and Functional Characterization of Non-Homologous End Joining Factors , Huasheng Wang

Nicotinamide Phosphoribosyltransferase In Smooth Muscle Cells And Aortic Integrity , Alanna R. Watson

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Department of Biochemistry and Molecular Biology Theses and Dissertations

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This collection contains theses and dissertations submitted by graduate students under the Department of Biochemistry and Molecular Biology for either a Master of Science degree or a Doctor of Philosophy degree.

Recent Submissions

OPTIMIZED ISOLATION AND QUANTIFICATION OF IN VIVO DISTRIBUTION OF EXOSOMES FOR POTENTIAL TARGETED THERANOSTIC APPLICATION

THE ROLE OF GPR109A IN REGULATION OF RETINAL ANGIOGENESIS AND BLOOD-RETINAL BARRIER AS A POTENTIAL THERAPEUTIC TARGET IN DIABETIC RETINOPATHY

A Molecular Basis of Chemoresistance in Bladder Cancer

Osteopontin as a novel immune checkpoint, gene regulation by the putative campylobacter jejuni diguanylate cyclase cbrr, glycosaminoglycans, chondroitinase, and molecular subtypes in bladder cancer.

HLA-G DIMER PROLONGS KIDNEY ALLOGRAFT SURVIVAL BY INHIBITING CD8+T CELL ACTIVATION AND GRANZYME B EXPRESSION

Investigating the Role of the Hdac3 Co-Repressor Complex in Glucocorticoid Signaling-Mediated Bone Marrow Lipid Storage with Age

CHOLINESTERASE INHIBITOR TOXICITY: MECHANISTIC STUDIES AND THERAPEUTIC STRATEGIES FOCUSED ON AXONAL TRANSPORT

Primary Tumor-Induced Immunity Is Suppressed By Surgery-Induced Inflammation In The Presence Of Residual Tumor Cells

DISCOVERY AND VALIDATION OF A NOVEL NEUTROPHIL ACTIVATION MARKER ASSOCIATED WITH OBESITY

Role of arginase in obesity-induced visceral adipose tissue dysregulation and endothelial dysfunction.

DNA METHYLATION AS A KEY PLAYER IN INFLAMMATION-MEDIATED COLON TUMORIGENESIS

The c-MYC oncogene deregulates global DNA methylation and hydroxymethylation to control genome-wide gene expression for tumor maintenance in leukemia/lymphoma

The Role of GPR109A in NAD+ Metabolism in Aging RPE

Immune regulation of tumor cell plasticity: A promising molecular target in breast cancer metastasis

THE TUMOR SECRETORY FACTOR ZAG PROMOTES WHITE ADIPOSE TISSUE BROWNING AND ENERGY WASTING IN CACHEXIA

Canonical wnt signaling in antigen presenting cells regulates microbiota-induced inflammation and immune cell homeostasis in the colon.

CXCR2 EXPRESSING TUMOR CELLS DRIVE VASCULAR MIMICRY IN ANTI-ANGIOGENIC THERAPY RESISTANT GLIOBLASTOMA

MECHANISM OF 12/15 LIPOXYGENASE-INDUCED RETINAL MICROVASCULAR DYSFUNCTION IN DIABETIC RETINOPATHY

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Home > Biochemistry > Dissertations, Theses, and Student Research

Biochemistry, Department of

Department of biochemistry: dissertations, theses, and student research.

Mitochondrial Metal Homeostasis: A look into iron and copper mobilization within mitochondria , Jonathan Dietz

Characterization of the Multifunctional Enzyme Proline Utilization A , YiZi Mao

Development of High Value oil traits using the model oilseed crop Camelina sativa , Evan Updike

Characterization of Sphingolipid Biosynthesis and Modification in Plants , Dongdong Zhang

The Role of Liver Sinusoidal Endothelial Cells in Liver Malady Homeostasis , Fatima Cabral

THE ROLE OF CONFORMATIONAL DYNAMICS IN ISOCYANIDE HYDRATASE CATALYSIS , Medhanjali Dasgupta

Dissecting the Regulatory Network of Sphingolipid Biosynthesis in Plants , Ariadna Gonzalez-Solis

Characterization of Human Pyrroline-5-Carboxylate Reductase Enzymes Responsible for L-Proline Biosynthesis , Sagar Patel

Protease OMA1 Modulates Mitochondrial Bioenergetics and Ultrastructure through Dynamic Association with MICOS Complex , Martonio P. Viana

TRANSCRIPTOMIC ANALYSES AND COMPUTATIONAL MODELING REVEAL THAT FATTY ACID TRANSPORT PROTEIN 2 (FATP2) IMPACTS THE TRANSCRIPTIONAL ACTIVITY OF PPARα THUS ALTERING THE LIPID METABOLIC LANDSCAPE , Vincent M. Perez

Xenobiotic Exposure Requires Mitochondrial Metabolism for REDOX Homeostasis and Survival in Astrocytes , Jordan Rose

Defining the Roles of Serine Palmitoyltransferase-Interacting Proteins in the Regulation of Sphingolipid Homeostasis , Athen N. Kimberlin

Investigation of Pathways for Complex Sphingolipid Biosynthesis in Arabidopsis thaliana (L.) Heynh , Kyle Luttgeharm

Functional Genomic Analyses of Switchgrass Developmental Processes , Nathan Palmer

Characterization of Inhibitors of Fatty Acid Transport Protein-2 in Cell and Animal Models , Nipun Saini

Reactive Oxygen Species Homeostasis and Proline Catabolism , Lu Zhang

Single Tube, Multiple Enzyme Reaction for Detection of UV and Oxidative Damage in Forensic Physiological Stains , Nicholas J. Eurek

REDOX REGULATION OF PROTEIN TRANSLATION IN EUKARYOTES , Maxim Gerashchenko

ER-associated Degradation and Cadmium Dependent Rescue of PCA1 , Nathan Smith

Investigation of Proline Utilization A: Kinetic Analysis of Substrate Channel-blocking Mutants and Creation of a Trifunctional Chimera Enzyme , Benjamin W. Arentson

Transcriptomic Analyses of the CO 2 -Concentrating Mechanisms and Development of Molecular Tools for Chlamydomonas reinhardtii , Andrew J. Brueggeman

MAKING CHLAMYDOMONAS REINHARDTII A BETTER MODEL ORGANISM: TACKLING THE INEFFICIENCY OF NUCLEAR TRANSGENE EXPRESSION AND IMPROVING METHODS FOR THE GENERATION AND CHARACTERIZATION OF INSERTIONAL MUTANT LIBRARIES , Thomas M. Plucinak

Investigations of Substrate Channeling in the Proline Oxidative Pathway , Nikhilesh Sanyal

Sinusoidal Endothelial Dysfunction in Non-Alcoholic Fatty Liver Disease. , Sandhya Lakshmi Gopalakrishnan

Studies on the Small Ubiquitin-Like Modifier (SUMO) E2 Conjugases of the SUMOylation System in Chlamydomonas reinhardtii and their Role in Stress Physiology , Amy R. Knobbe

Developing a High Throughput Protocol for Using Soil Molecular Biology as Trace Evidence , Sabreena A. Larson

Phylogenetic Engineering of the Ribulose-1,5-bisphosphate Carboxylase/Oxygenase Large Subunit in Chlamydomonas Reinhardtii , Boon Hoe Lim

UNDERSTANDING OF FUNCTIONS OF SELENOPROTEINS AND DIETARY SELENIUM BY USING ANIMAL MODELS , Marina V. Kasaikina

Functional Studies of Human Cellular Detoxification Enzymes , Melanie Neely Willis

The crosstalk between human fatty acid transport protein 1 and fatty acid transport protein 4 , Zhe Yuan

METHIONINE-R-SULFOXIDE REDUCTASES AND BIOLOGICAL IMPORTANCE OF FREE METHIONINE SULFOXIDE REDUCTION , Byung Cheon Lee

The In Situ Function of a Microbial Community Profiled by FT-IR: A Snapshot in Time , Ryan Roberts

Consequences of Hyaluronan Metabolism on Cell Cycle Progression in Prostate Tumor Growth and Metastasis , Alamelu G. Bharadwaj

Identification and Characterization of a Cadmium-Transporting P-Type ATPase in Yeast Saccharomyces cerevisiae , David J. Adle

Structural Basis of Allosteric and Intrasteric Regulation in Human Cystathionine β-Synthase and its Regulation by a CXXC Motif , Suvajit Sen

Studies on Nutritional Muscular Dystrophy. I. Dietary Factors, II. Fibrosis and Lipomatosis of Tissues , Violet Myrtle Wilder

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Home > USC Columbia > Medicine, School of > Biomedical Science > Biomedical Science Theses and Dissertations

Biomedical Science Theses and Dissertations

Theses/dissertations from 2023 2023.

Gluten Free Diet Ameliorates SI Enteropathy in IGA Deficient Mice , Ryan Albert William Ball

Aortopathies: Mechanism of Pathogenesis and Therapy , Mengistu G. Gebere

Leptin, Serotonin, and the Control of Food Intake , Nicholas David Maxwell

Targeting Macrophages in Cancer Models Using Natural Compounds , Sierra Jordan McDonald

Neurodevelopmental and Transient Impacts of Brain Kynurenic Acid Elevation and Sleep-Wake Behavior , Katherine Rentschler

Exploration Into the Relationship Between Colitis and Depression: A Potential Role for the Aryl Hydrocarbon Receptor , Kasie Lynn Roark

B-Cell-Specific MHCII Promotes Host-Microbiome Symbiosis , Mary Melissa Roland

Cardiac Imaging in Mice With Micro-Computed Tomography: An Assessment , Kyle Porter Stegmann

Theses/Dissertations from 2022 2022

Role of Epigenome in Regulation of Inflammation By AHR Ligands 2,3,7,8-Tetrachlorodibenzo-P-Dioxin and 6-Formylindolo[3,2-B] Carbazole , Alkeiver Cannon

Neurochemical, Molecular, and Behavioral Effects of Intranasal Insulin , Jennifer Marie Erichsen

Sex Differences and Potential Non-invasive Treatments for Calcific Aortic Valve Disease , Henry Pascal Helms

Decellularization Strategies of Naturally Derived Biomaterials for Tissue Engineering Applications , Julia Elizabeth Hohn

Role of AhR in the Epigenetic Regulation of Immune Cells in Lungs During Acute Respiratory Distress Syndrome , Bryan Latrell Holloman

The Submission of a Section 513(g) Request For Information , Morgan Ashley Lano

Engineering and Optimization of an AAV Based Viral Vector to Limit the In-Vitro Expression of SARS-CoV-2 Spike-Protein , Ronald Anderson Smithwick

In Vitro and in Vivo Studies of Mediator Kinase , Lili Wang

Theses/Dissertations from 2021 2021

Role of AhR Ligands in Immune Modulation to Suppress Inflammation Through the Regulation of Microrna and Gut Microbiome , Osama Azeldeen Abdulla

Role of Estrogen in Regulating Diet-Induced Obesity in Females , Ahmed Aladhami

Impact of Acetylcholine on Internal Pathways To Basal Amygdala Pyramidal Neurons , Tyler Daniel Anderson-Sieg

Pseudomyxoma Peritonei Derived Cancers: A Novel Study on Growth and Growth Suppression Utilizing Common Colorectal Cancer Agents , Raymond Kennith Bogdon

Impact of Acetylcholine on Amygdala Network Oscillations , Joshua Xavier Bratsch-Prince

Real Time Neurochemical Analysis of the Brain For Pharmacological Treatments in Mood Disorders And Neurodegeneration , Anna Marie Buchanan

Regulation of Inflammatory Processes by Tryptamine, Cannabidiol and 2,3,7,8-Tetrachlorodibenzo-P-Dioxin , Nicholas Dopkins

Study of the Effect of B-Cell-Intrinsic Mhcii Antigen Presentation on Germinal Center B Cell Evolution Using The Brainbow Mouse Model , Nia Hall

Mechanism of Therapeutic Efficacy of New Drugs in Glioblastoma , Firas Hameed Khathayer

The Effect of Low Dose Penicillin on Tumor Development in Apc Min/+ Mice , Kinsey Ann Sierra Meggett

Defining the Pathophysiology of Gut Humoral Immunodeficiency , Ahmed Dawood Mohammed

The Role PDE11A4 Signaling and Compartmentalization in Social Behavior , Kaitlyn Pilarzyk

Anatomical Correlates of Age-Related Basal Forebrain Dysfunction , Brandy Lynn Somera

A Novel Model to Study Adipose-Derived Stem Cell Differentiation , Austin N. Worden

Theses/Dissertations from 2020 2020

Molecular Mechanisms of Loss of E7 Expression in HPV16 – Transformed Human Keratinocytes , Fadi Farooq Abboodi

17 β-Estradiol and Phytoestrogens Attenuate Apoptotic Cell Death in HIV-1 Tat Exposed Primary Cortical Cultures , Sheila Marie Adams

Helicobacter’s Effects on Colitis/Colon Cancer and the Response to Indole 3-Carbinol , Rasha Raheem Abdulhamza Alkarkoushi

A Comparative Study of Cannabinoids & CB1 Receptor GI Signaling , Haley Kristen Andersen

Expansion Microscopy: A New Approach to Microscopic Evaluation , Ashley Ferri

The Role of Acute and Chronic Neuroinflammation in Depression: Uncovering the Relationship Between Histamine and Serotonin Transmission , Melinda Hersey

The Use of Natural Anthraquinone Emodin as a Primary and Complementary Therapeutic in the Treatment of Colorectal Cancer , Alexander-Jacques Theodore Sougiannis

The Effects of Super-Resolution Microscopy on Colocalization Conclusions Previously Made With Diffraction-Limited Systems in the Biomedical Sciences , Madison Emily Yemc

Theses/Dissertations from 2019 2019

Role of Epigenome and Microbiome in Cannabinoid and Aryl Hydrocarbon Receptor-Mediated Regulation of Inflammatory and Autoimmune Diseases , Zinah Zamil Al-Ghezi

Tissue-Specific Roles of Transforming Growth Factor Beta Ligands in Cardiac Outflow Tract Malformations and Calcific Aortic Valve Disease , Nadia Al-Sammarraie

Role of Epigenetic, Molecular and Cellular Pathways in the Regulation of Inflammation , William James Becker

Neurochemical and Behavioral Outcomes of Intranasal Orexin Administration in Young and Aged Animals , Coleman Blaine Calva

Interdependent Mechanisms of Stress Susceptibility , Julie Elaine Finnell

Astrocyte Sensitivity to Dopamine in Culture and Ex Vivo , Ashley L. Galloway

Three-Dimensional Plasma Cell Survival Microniche in Multiple Myeloma , Katrina A. Harmon

Role of Epigenome and Microbiome in Endocannabinoid-Mediated Regulation of Inflammation During Diet-Induced Obesity , Kathryn Miranda

Epigenetic and Purinergic Regulation of Mast Cells Mediator Release , Zahraa Abdulmohsin Mohammed

Effect of TCDD, an Environmental Contaminant, on Activation of AHR Leading to Induction of Myeloid Derived Suppressor Cells (MDSCS) and the Ability of Resveratrol, a Botanical, to Neutralize this Effect , Wurood Hantoosh Neamah

An Anatomical Basis of the Differential Cholinergic Modulation of Valence-Specific Pyramidal Neurons in the Basolateral Amygdala , Nguyen Vu

Analysis of Cellular Interactions Within a Collagen Hydrogel , Austin N. Worden

Theses/Dissertations from 2018 2018

Role of Mammary Microenvironment in Promoting Left-Right Differences in Tumor Progression, Metastasis, and Therapeutic Response , Huda Issa Atiya

Enhancements in Alginate Microencapsulation Technology & Impacts on Cell Therapy Development , Marwa Belhaj

Effect Of Resveratrol On The Development Of Eczema , Christopher Carlucci

The Nervous System And Cancers Of The Head And Neck , Christian A. Graves

Turning Up Antitumor Immunity Against Breast Cancer , Johnie Hodge

Exploring Alternative Therapeutic Interventions For The Treatment Of Leigh Syndrome , Stephanie Martin

Regulation Of Prostaglandin D2 And Angiogenesis-Related Factors From Human Skin Mast Cells By Interleukin-6 And Resveratrol , Cody Cody McHale

Advanced Clearing Methods and Imaging Techniques for Optimized Three- Dimensional Reconstruction of Dense Tissues , Caleb A. Padgett

Role Of MIR-489 In HER2 Positive Breast Cancer , Yogin Patel

Operation Of The Leica SP8 Multiphoton Confocal System Using Single Or Multiple Fluorochromes , Amy E. Rowley

Theses/Dissertations from 2017 2017

Garlic Inhibits Inflammation during Dengue Infection , Alex R. Hall

Functional Role of the Homeobox Transcription Factor Six1 in Neoplastic Transformation of Human Keratinocytes , Maria Hosseinipour

Individual Differences in Markers of Cholinergic Signaling Correlating to Fear and Extinction Learning , Grace C. Jones

The Role Of Cyclin-Dependent Kinase 8 In Vascular Disease , Desiree Leach

Succination Impairs Protein Folding and Promotes Chop Stability in the Adipocyte during Diabetes , Allison Manuel

Muscarinic Acetylcholine Receptor M1’s Impact on Fear Extinction Learning , Joshua R. McElroy

Hemodynamic Regulation Of Cardiac Valve Development , Vinal Menon

The Role Of Inflammation In Atherosclerosis , Fatma Saaoud

Synergism of Quercetin and Sodium Butyrate for Controlling Growth of Glioblastoma , Matthew Alan Taylor

Mast Cells and Lipid Cross-Talk in Skin Inflammation , Piper Alexandra Wedman

Theses/Dissertations from 2016 2016

Tumor Suppressor p53 Response To UV Light In Normal Human Keratinocyte Strains From Different Individuals , Fadi Farooq Abboodi

Vitamin D and Stress Fractures in Collegiate and Professional Athletes , Christian Michael Askew

Linking Obesity & Breast Cancer: Role Of Monocyte Chemoattractant Protein-1 And High Fat Diet-Induced Inflammation On Mammary Tumorigenesis , Taryn L. Cranford

The Identification Of The Direct And Indirect Pathways Through Which Leptin Facilitates Synaptic Plasticity In The Hippocampus , Catherine Van Doorn

Morphogenic Effects Of Dopamine In Cultured Rat Hippocampal Astrocytes , Ashley L. Galloway

Emodin Regulates Macrophage Polarization: Application In Breast Cancer Treatment , Stephen Iwanowycz

Differences In Resting-State Functional Connectivity Of Chronic Migraine, With And Without Medication Overuse Headache, And The Effectiveness Of Sphenopalatine Ganglion Block As A Treatment For Repairing Dysfunctional Connectivity. , Kaitlin Krebs

Prospective Assessment Of Health Disparities And Injury Risk Factors At Basic Combat Training At Ft. Jackson , Kristin Lescalleet

Transcriptional And Post-Transcriptional Regulation Of NRF2 In The Heart By The Deubiquitinase CYLD , Bryan J. Mathis

Regulation of Chronic and Acute Inflammatory Disease by microRNA and Microbiota , Pegah Mehrpouya-Bahrami

The Effect of Arsenic on Type 2 Diabetes and Inflammation , Kayla Penta

Factors Influencing The Collagen Fiber Angle Distribution in The Mouse Aorta , Shana Roach Watson

The Role of Epidermal Stem/Progenitor-Like Cells In HPV-Mediated Pre-Neoplastic Transformation , Yvon L. Woappi

Theses/Dissertations from 2015 2015

Extensive Genome Rearrangements of Caulobacter K31 and Genomic Diversity of type B3 Bacteriophages of Caulobacter Crescentus , Kurt Taylor Ash

Evaluating Muscle Fiber Architecture , Morgan Ashley Flahive

Characterization of STARD4 and STARD6 Proteins in Human Ovarian Tissue and Human Granulosa Cells and Cloning of Human STARD4 Transcripts , Aisha Shaaban

Cannabinoid-mediated Epigenetic Regulation of Immune Functions , Jessica Margaret Sido

The Effect of 3D Collagen Scaffolds on Regulating Cellular Responses , Chad Simmons

Theses/Dissertations from 2014 2014

Metformin Arrests Growth and Induces Apoptosis of Neuroblastoma Cells , Nadia Al-Sammarraie

Cellular and Biochemical Effects of Sparstolonin B on Endothelial Cells to Inhibit Angiogenesis , Marwa Belhaj

An Evolutionary Perspective on Infectious and Chronic Disease , John Eberth

Status Epilepticus Induced Alterations in Hippocampal Anatomy and Neurotransmission , Denise K. Grosenbaugh

The Cardio-Protective Effects of Substance P in Both Ischemia/Reperfusion and and Short-Term Hypoxia Rat Models , Shaiban Jubair

MUSCARINIC MODULATION OF BASOLATERAL AMYGDALA , Lei Liu

MCP-1 In Colorectal Cancer: Benefits of Exercise , Jamie Lee McClellan

Diethylstilbestrol (DES) mediates immune suppression via modulation of microRNA expression in mice , Martine Menard

Effects of cPLA-2 on the Migration and Proliferation of Human Vascular Smooth Muscle Cells and the 2-D Migratory Patterns of Tropomyosin in Femoral and Abdominal Aorta Tissue , Jaimeson Thomas Powell

The Role of MicroRNA in Staphylococcal Enterotoxin B-Induced Inflammation and Acute Lung Injury , Roshni Rao

ENHANCING PERIPHERAL OPIOID ANALGESIA: DEVELOPMENT OF VIRAL VECTOR AND SMALL PEPTIDE THERAPIES , Sherika Smith

ROLE OF APELIN AND ENDOTHELIN SYSTEMS IN THE PAIN ASSOCIATED WITH SICKLE CELL DISEASE , Terika Smith

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Dissertations / Theses on the topic 'Medical Biochemistry and Clinical Chemistry'

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Stemp, Melissa. "Biomarkers of disease : concentrations in the serum of women during natural and stimulated ovarian cycles and during early pregnancy." Thesis, Edith Cowan University, Research Online, Perth, Western Australia, 2013. https://ro.ecu.edu.au/theses/865.

Woods, Nicole Natasha Brooks Lee R. "The role of biomedical knowledge in medical diagnosis by learners." *McMaster only, 2005.

Meiklejohn, Barbara A. "Ektachem evaluation /." Online version of thesis, 1985. http://hdl.handle.net/1850/9634.

Wabomba, Mukire John. "Signal and Image Processing Techniques for Environmental and Clinical Applications of Infrared Spectroscopy." Ohio University / OhioLINK, 2002. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1040131767.

Carberry, Helen. "Semiotic analysis of clinical chemistry: for "knowledge work" in the medical sciences." Thesis, Queensland University of Technology, 2003. https://eprints.qut.edu.au/15809/1/Helen_Carberry_Thesis.pdf.

Carberry, Helen. "Semiotic analysis of clinical chemistry: for " knowledge work " in the medical sciences." Queensland University of Technology, 2003. http://eprints.qut.edu.au/15809/.

Bani, Rashaid Ayat H. "Clinical and Forensic Biomarkers in Human Hair." Ohio University / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1407256298.

Wang, Yin 1951. "Influences of membrane biophysical properties on the Metarhodopsin I to Metarhodopsin II transition in visual excitation." Diss., The University of Arizona, 1997. http://hdl.handle.net/10150/282520.

Persson, Johanna. "Hälsoundervisning : Elevers syn på hälsa inom ämnet Idrott och hälsa." Thesis, University of Kalmar, School of Human Sciences, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:hik:diva-2478.

Fler unga människor än någonsin är idag överviktiga och stress och stressrelaterade symptom drabbar idag allt fler unga. Därför är det viktigt att unga människor får kunskaper om hur de på bästa sätt kan ta hand om sig själva.

 Syftet med detta arbete är att undersöka hur elever som läser gymnasiets kurs Idrott och hälsa A ser på den hälsoundervisning de får.

Detta är relevant för alla som arbetar som idrott och hälsa lärare för att kunna hitta en jämkning mellan kursplan och elevernas tankar och förkunskaper.

 Genom intervjuer och fokusintervjuer kom jag fram till att eleverna vill lära sig mer om stress och hur man hanterar stress samt om kost. Eleverna tycker däremot att idrottsläraren inte är rätt person att lära ut kunskaper om tobak.

Tang, Yuanyuan. "Nitric Oxide/Peroxynitrite Imbalance Induces Adhesion of Cancer Cells to Lymphatic Endothelium - Clinical Implications for Cancer Metastasis." Ohio University / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1439563414.

Ozinsky, Adrian. "Post-translational processing of the low density lipoprotein receptor." Doctoral thesis, University of Cape Town, 1996. http://hdl.handle.net/11427/26672.

Lu, Liang. "CLINICAL AND ANIMAL STUDIES OF LIPID-DERIVED PROTEIN MODIFICATIONS IN AUTISM, KIDNEY DIALYSIS, KERATITIS AND AGE-RELATED MACULAR DEGENERATION." Case Western Reserve University School of Graduate Studies / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=case1180231149.

Barnard, Sandra H. "Amalgamation of Nucleosides and Amino Acids in Antibiotic Biosynthesis." UKnowledge, 2013. http://uknowledge.uky.edu/pharmacy_etds/20.

Borg, Mathias. "Study of the insulin-like peptide 3 in human platelets." Thesis, Linköping University, Department of Physics, Chemistry and Biology, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-21016.

The insulin-like 3 peptide is autocrine/paracrine insulin-related hormone with a size of approximately 6kDa [1]. It mediates through a leucine richG-coupled receptor named LGR8. INSL3 is mainly expressed in human Leydig cells and is directly responsible for migration of the testis during the pre-natal period in maledevelopment. [2]

INSL3 mRNA has recently been verified in human platelets whereas no mRNA has been detected for LGR8 (by Sanofi-Aventis GmbH in Frankfurt,Germany), indicating that INSL3 might be released through paracrine functions at sites of platelet adhesion and aggregation upon a vascular injury.Furthermore, has activated platelets been shown to translate essential proteins upon activation, in a term called “signal-dependent protein synthesis”.The B-Cell lymphoma-3 protein (BCL-3) is an example of such a protein [3], and there is a possibility that INSL3 might be also.

In this thesis we wanted to detect the relaxin- like peptide 3 hormone (INSL3). (Its function, location and the timeframe of its release, when/if it issecreated in stimulated platelets).The source of platelet-derived INSL3 can be found with Western blotting and Enzyme immunoassay.

Detection of the insulin-like 3 peptide in human platelets turned out to be a difficult challenge due to the small amount of INSL3 secretion uponplatelet activation; hence the total amount of INSL3 produced might be below detection limit.

Rafael, Venson. "Hollow-fibre liquid-phase microextraction : investigation into the potential use in clinical and forensic toxicology." Thesis, University of Glasgow, 2017. http://theses.gla.ac.uk/8697/.

Shah, Ketan. "Development of clinical biomarkers of DNA double strand breaks for cancer care." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:2e6b2595-fbbc-4fff-80e2-bec8a4d9d15e.

Alabdulwaheed, Abdulhameed. "3D-Printed Fluidic Devices and Incorporated Graphite Electrodes for Electrochemical Immunoassay of Biomarker Proteins." Digital Commons @ East Tennessee State University, 2018. https://dc.etsu.edu/etd/3477.

English, Suzanne Elizabeth. "Within-host evolution of HIV-1 and the analysis of transmissible diversity." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:df24b49c-fb27-49a3-bd2e-3e38008e9da4.

Tian, Lei. "BIOCHEMICAL CHARACTERIZATION OF HUMAN MISMATCH RECOGNITION PROTEINS MUTSα AND MUTSβ." UKnowledge, 2010. http://uknowledge.uky.edu/gradschool_diss/43.

Paripelly, Rammohan. "Molecular Level Interaction of Human Fibroblast Growth Factor-1 (hFGF-1) With Phloridzin." TopSCHOLAR®, 2013. http://digitalcommons.wku.edu/theses/1314.

Wallin, Olof. "Preanalytical errors in hospitals : implications for quality improvement of blood sample collection." Doctoral thesis, Umeå universitet, Institutionen för medicinsk biovetenskap, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1672.

Sayce, Andrew Cameron. "Iminosugars as dengue virus therapeutics : molecular mechanisms of action of a drug entering clinical trials." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:8d4da0ce-bfa6-447d-a280-630479f898af.

Wright, Sam Mathew. "Structural and biophysical studies of RNA-dependent RNA polymerases." Thesis, University of Oxford, 2010. http://ora.ox.ac.uk/objects/uuid:d5c2a16d-e1e2-4c22-aca5-70f72aa96853.

Beer, Nicola L. "The role of genetic variation in glucokinase and glucokinase regulatory protein in diabetes and related traits." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:87f8ea0d-9528-49fd-8f01-5f976cf9f210.

Klinac, Dragana. "The evaluation of midazolam on head injured patients in the prehospital setting." Thesis, Edith Cowan University, Research Online, Perth, Western Australia, 2008. https://ro.ecu.edu.au/theses/195.

Zhou, Gang. "PURIFICATION AND CHARACTERIZATION OF BLOOD ASPIRIN HYDROLASES." Cleveland State University / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=csu1338916020.

Källebring, Tina. "THE EXPRESSION OF THROMBOMODULIN, TISSUE FACTOR, TISSUE FACTOR PATHWAY INHIBITOR AND ENDOTHELIAL PROTEIN C RECEPTOR IN NORMAL AND IUGR PLACENTA." Thesis, Uppsala University, Department of Medical Biochemistry and Microbiology, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-6156.

The aim of this study was to examine the expression of Thrombomodulin, Tissue Factor, Tissue Factor Pathway Inhibitor and Endothelial Protein C Receptor in placenta throughout the three phases of the third trimester in the normal placenta and in IUGR placenta from full term.

Twenty-five normal placenta samples and twenty-five IUGR placenta samples were obtained and each sample was stained by immunohistochemistry using monoclonal antibodies. Each antibody was optimised for antigen retrieval method and for optimal dilution, before been applied to the test tissue.

The results showed that each of the antibodies mentioned was expressed in normal placenta and in IUGR placenta.

No significant difference could be established concerning the expression of each antibody mentioned between normal and IUGR placenta.

Sukthankar, Pinakin Ramchandra. "Biophysical characterization of branched amphiphilic peptide capsules and their potential applications in radiotherapy." Diss., Kansas State University, 2014. http://hdl.handle.net/2097/18174.

Gaentzsch, Ricarda E. G. "Establishment and maintenance of the DNA methylation pattern in the human alpha-globin cluster." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:fecf70d2-4845-4f42-b890-c163a1020eec.

Mai, Yvonne M. "Use of various health care providers and the associated clinical and humanistic outcomes in an ambulatory Medicare population." Scholarly Commons, 2016. https://scholarlycommons.pacific.edu/uop_etds/265.

Pang, Chunyan. "REGULATION OF L-TYPE VOLTAGE-DEPENDNET CALCIUM CHANNELS BY THE REM GTPASE." UKnowledge, 2008. http://uknowledge.uky.edu/gradschool_diss/656.

Lundin, Desiré. "Do the new signal transduction modulators have activity in vitro in tumor cells from ovarian carcinoma and lymphoma?" Thesis, Uppsala University, Department of Medical Biochemistry and Microbiology, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-6158.

During the last decades, chemotherapy with cytotoxic drugs has played a significant role in cancer therapy. It’s important to develop new anticancer drugs, and drug sensitivity testing in vitro can be used to find the right diagnosis for the newly developed substances.

The aim of this study was to investigate the cytotoxic activity of the new signal transduction modulators bortezomib, gefitinib and PKC412. The well-established substances cisplatin, cytarabine, doxorubicin and vincristin were investigated for comparison.

The activity of the cytotoxic drugs was analysed in human tumor samples from patients with ovarian carcinoma (n=16) and lymphoma (n=15) by using the Fluorometric Microculture Cytotoxicity Assay (FMCA). The testing of cellular drug resistance by FMCA was accomplished successfully in 33 out of the 34 samples (97%).

The results of this study indicated that the activity of cytotoxic drugs in tumor cells obtained from patients with ovarian carcinoma and lymphoma may be detected by the FMCA. It also suggested that bortezomib and gefitinib could represent promising agents for treatment of ovarian carcinoma and that PKC412 might be of less use for patients with this diagnose.

He, Qinghao. "The Degradation of Pharmaceutical Pollutants in Wastewater Catalyzed by Chloroperoxidase and the Construction of Chloroperoxidase H105R Mutant." FIU Digital Commons, 2016. http://digitalcommons.fiu.edu/etd/2540.

Borg, Johanna. "Jämförelse av kemiinstrument och validering av referensintervall hos hund och katt." Thesis, Högskolan Kristianstad, Fakulteten för naturvetenskap, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:hkr:diva-22058.

Sanvitale, Caroline E. "Investigation of kinase activation in fibrodysplasia ossificans progressiva." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:3ac802e9-a864-4a0d-8e13-f21bcffc957d.

Lee, Hyosung. "DEVELOPMENT OF NOVEL AHR ANTAGONISTS." UKnowledge, 2010. http://uknowledge.uky.edu/gradschool_diss/103.

Whalen, Daniel M. "Structural and functional studies of the hedgehog signalling pathway." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:ce0e765c-04f1-4a64-a67b-89204ecaa155.

Cisek, Katryna. "Rational Optimization of Small Molecules for Alzheimer’s Disease Premortem Diagnosis." The Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1338325484.

Chitranshi, Priyanka. "Interactions of small molecules with duplex DNA and lesion containing G-quadruplex DNA." Scholarly Commons, 2013. https://scholarlycommons.pacific.edu/uop_etds/145.

Fierer, J. O. "Development of spontaneous isopeptide bond formation for ligation of peptide tags." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:833289ee-87cf-42f0-a66f-ca9ef9dd6420.

Lucca, Julie Ann. "ASSOCIATIONS BETWEEN ALCOHOL CONSUMPTION AND FASTING BLOOD GLUCOSE IN YOUNG ADULTS." DigitalCommons@CalPoly, 2013. https://digitalcommons.calpoly.edu/theses/1057.

Buen, Zachary. "Establishment of gas-phase thermochemical values of various small organic compounds and oligopeptides." Scholarly Commons, 2016. https://scholarlycommons.pacific.edu/uop_etds/262.

Mindemark, Mirja. "The Use of Laboratory Analyses in Sweden : Quality and Cost-Effectiveness in Test Utilization." Doctoral thesis, Uppsala universitet, Klinisk kemi, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-120554.

Williams, Jennifer Nicole. "Metal Containing Nucleosides that Function as Therapeutic and Diagnostic Agents Against Brain Cancer." Cleveland State University / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=csu1409238775.

Lopez, Aguilar Aime. "Peptides as therapeutics." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:d893e962-5cb9-4d50-bbe1-c5183418295c.

O'Hara, Connor P. "Inhibition of Cancer Stem Cells by Glycosaminoglycan Mimetics." VCU Scholars Compass, 2019. https://scholarscompass.vcu.edu/etd/5989.

Soler, Lecha Anna. "Desenvolupament de la gestió del risc al laboratori clínic. Aplicació al procés analític del Programa de Cribratge Neonatal de Catalunya." Doctoral thesis, Universitat de Barcelona, 2020. http://hdl.handle.net/10803/670019.

Söderberg, Johan. "Sources of preanalytical error in primary health care : implications for patient safety." Doctoral thesis, Umeå universitet, Klinisk kemi, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-21256.

Fu, Josephine K. Y. "Functional characterization of the teleost multiple tissue (tmt) opsin family and their role in light detection." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:39bc18bb-16cb-4549-94cd-5f872daafe7e.

Chen, Bety. "Estudo dos polimorfismos das regiões hipervariáveis HV1 e HV2 do DNA mitocondrial da população brasileira aplicado à identificação humana." Universidade de São Paulo, 2003. http://www.teses.usp.br/teses/disponiveis/9/9136/tde-19032015-095415/.

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Home > CNS > BIOCHEM > MCB > MCB_THESES

Molecular and Cellular Biology Masters Theses Collection

Theses from 2024 2024.

The Impact of a Non-ionic Adjuvant to the Persistence of Pesticides on Produce Surfaces , Daniel Barnes, Molecular & Cellular Biology

Investigating the Role of Got2 in Murine Organogenesis and Placenta Development , Olivia Macrorie, Molecular & Cellular Biology

Chromatin Accessibility Impacts Knockout of Mt-Bell4 Transcription Factor , Thomas Redden, Molecular & Cellular Biology

UNDERSTANDING THE FUNCTIONAL IMPACT OF DISEASE-ASSOCIATED PHOSPHORYLATION SITES ON THE NEURODEGENERATIVE PROTEIN TAU , Navya T. Sebastian, Molecular & Cellular Biology

Theses from 2023 2023

Elucidating the Priming Mechanism of ClpXP Protease by Single-Domain Response Regulator CpdR in Caulobacter crescentus , Kimberly E. Barker, Molecular & Cellular Biology

The Discovery of a Novel Bacteria from a Large Co-assembly of Metagenomes , Matthew Finkelberg, Molecular & Cellular Biology

Investigating Diterpene Biosynthesis in Medicago Truncatula , Sungwoo Hwang, Molecular & Cellular Biology

Combining Simulation and the MspA Nanopore to Study p53 Dynamics and Interactions , Samantha A. Schultz, Molecular & Cellular Biology

Caulobacter ClpXP Adaptor PopA’s Domain Interactions in the Adaptor Hierarchy of CtrA Degradation , Thomas P. Scudder, Molecular & Cellular Biology

Climate Change, Giant Viruses and Their Putative Hosts , Sarah K. Tucker, Molecular & Cellular Biology

Theses from 2022 2022

Changes in Gene Expression From Long-Term Warming Revealed Using Metatranscriptome Mapping to FAC-Sorted Bacteria , Christopher A. Colvin, Molecular & Cellular Biology

Determining CaMKII Variant Activities and Their Roles in Human Disease , Matthew J. Dunn, Molecular & Cellular Biology

Developmental Exposures to PFAS Mixtures Impair Elongation of the Exocrine Pancreas in Zebrafish (Danio rerio) , Emily M. Formato, Molecular & Cellular Biology

A Metatranscriptomic Analysis of the Long-Term Effects of Warming on the Harvard Forest Soil Microbiome , Brooke A. Linnehan, Molecular & Cellular Biology

Characterization of the Poly (ADP-Ribose) Polymerase Family in the Fusarium oxysporum Species Complex , Daniel Norment, Molecular & Cellular Biology

Theses from 2021 2021

Exploring Knockdown Phenotypes and Interactions between ATAD3 Proteins in Arabidopsis thaliana , Eli S. Gordon, Molecular & Cellular Biology

Development of a Site-Specific Labeling Assay to Study the Pseudomonas aeruginosa Type III Secretion Translocon in Native Membranes , Kyle A. Mahan, Molecular & Cellular Biology

Liposomal Nanoparticles Target TLR7/8-SHP2 to Repolarize Macrophages to Aid in Cancer Immunotherapy , Vaishali Malik, Molecular & Cellular Biology

Hsp70 Phosphorylation: A Case Study of Serine Residues 385 and 400 , Sashrika Saini, Molecular & Cellular Biology

Activation of Nrf2 at Critical Windows of Development Alters Protein S-Glutathionylation in the Zebrafish Embryo (Danio rerio) , Emily G. Severance, Molecular & Cellular Biology

Utilizing Fluorescence Microscopy to Characterize the Subcellular Distribution of the Novel Protein Acheron , Varun Sheel, Molecular & Cellular Biology

Theses from 2020 2020

The Association Between Sperm DNA Methylation and Sperm Mitochondrial DNA Copy Number , Emily Houle, Molecular & Cellular Biology

Gene Expression Regulation in the Mouse Liver by Mechanistic Target Of Rapamycin Complexes I and II , Anthony Poluyanoff, Molecular & Cellular Biology

Sperm Mitochondrial DNA Biomarkers as a Measure of Male Fecundity and Overall Sperm Quality , Allyson Rosati, Molecular & Cellular Biology

Exploration of the Association between Muscle Volume and Bone Geometry Reveals Surprising Relationship at the Genetic Level , Prakrit Subba, Molecular & Cellular Biology

Theses from 2019 2019

Studies on the Interaction and Organization of Bacterial Proteins on Membranes , Mariana Brena, Molecular & Cellular Biology

Investigating The Role Of LBH During Early Embryonic Development In Xenopus Laevis , Emma Weir, Molecular & Cellular Biology

Theses from 2018 2018

Exploring the Influence of PKC-theta Phosphorylation on Notch1 Activation and T Helper Cell Differentiation , Grace Trombley, Molecular & Cellular Biology

Theses from 2017 2017

Partial Craniofacial Cartilage Rescue in ace/fgf8 Mutants from Compensatory Signaling From the Ventricle of Danio Rerio , Douglas A. Calenda II, Molecular & Cellular Biology

THE FAR C-TERMINUS OF TPX2 CONTRIBUTES TO SPINDLE MORPHOGENESIS , Brett Estes, Molecular & Cellular Biology

Characterization of Calcium Homeostasis Parameters in TRPV3 and CaV3.2 Double Null Mice , Aujan Mehregan, Molecular & Cellular Biology

Microtransplantation of Rat Brain Neurolemma into Xenopus Laevis Oocytes to Study the Effect of Environmental Toxicants on Endogenous Voltage-Sensitive Ion Channels , Edwin Murenzi, Molecular & Cellular Biology

Regulation of Katanin Activity on Microtubules , Madison A. Tyler, Molecular & Cellular Biology

Theses from 2016 2016

The Role of MicroRNAs in Regulating the Translatability and Stability of Target Messenger RNAs During the Atrophy and Programmed Cell Death of the Intersegmental Muscles of the Tobacco Hawkmoth Manduca sexta. , Elizabeth Chan, Molecular & Cellular Biology

An in Vivo Study of Cortical Dynein Dynamics and its Contribution to Microtubule Sliding in the Midzone , Heather M. Jordan, Molecular & Cellular Biology

A Genetic Analysis of Cichlid Scale Morphology , Kenta C. Kawasaki, Molecular & Cellular Biology

Modulation of Notch in an Animal Model of Multiple Sclerosis , Manit Nikhil Munshi, Molecular & Cellular Biology

One-Carbon Metabolism Related B-Vitamins Alter The Expression Of MicroRNAS And Target Genes Within The Wnt Signaling Pathway In Mouse Colonic Epithelium , Riccardo Racicot, Molecular & Cellular Biology

Characterizing the Inhibition of Katanin Using Tubulin Carboxy-Terminal Tail Constructs , Corey E. Reed, Molecular & Cellular Biology

The Identification of Notch1 Functional Domains Responsible for its Physical Interaction with PKCθ , Wesley D. Rossiter, Molecular & Cellular Biology

Dynamics of Microtubule Networks with Antiparallel Crosslinkers , Kasimira T. Stanhope, Molecular & Cellular Biology

Modifications of Myofilament Structure and Function During Global Myocardial Ischemia , Mike K. Woodward, Molecular & Cellular Biology

Theses from 2015 2015

Regulation of Jak1 and Jak2 Synthesis through Non-Classical Progestin Receptors , Hillary Adams, Molecular & Cellular Biology

Antineoplastic Effects of Rhodiola Crenulata on B16-F10 Melanoma , Maxine Dudek, Molecular & Cellular Biology

RNAi Validation of Resistance Genes and Their Interactions in the Highly DDT-Resistant 91-R Strain of Drosophila Melanogaster , Kyle Gellatly, Molecular & Cellular Biology

Characterization of Protein-Protein Interactions for Therapeutic Drug Design Utilizing Mass Spectrometry , Alex J. Johnson, Molecular & Cellular Biology

Promoting Extracellular Matrix Crosslinking in Synthetic Hydrogels , Marcos M. Manganare, Molecular & Cellular Biology

Characterization of the Reconstituted and Native Pseudomonas aeruginosa Type III Secretion System Translocon , Kathryn R. Monopoli, Molecular & Cellular Biology

Thermocycle-regulated WALL REGULATOR INTERACTING bHLH Encodes a Protein That Interacts with Secondary-Cell-Wall-Associated Transcription Factors , Ian P. Whitney, Molecular & Cellular Biology

Theses from 2014 2014

Engineering Camelina sativa for Biofuel Production via increasing oil yield and tolerance to abiotic stresses , Kenny Ablordeppey, Molecular & Cellular Biology

Designing a Pore-Forming Toxin Cytolysin A (ClyA) Specific to Target Cancer Cells , Alzira Rocheteau Avelino, Molecular & Cellular Biology

The Role of the Novel Lupus Antigen, Acheron, in Moderating Life and Death Decisions , Ankur Sheel, Molecular & Cellular Biology

Expression and Purification of Human Lysosomal β-galactosidase from Pichia Pastoris , Sarah E. Tarullo, Molecular & Cellular Biology

Properties of Potential Substrates of a Cyanobacterial Small Heat Shock Protein , Yichen Zhang, Molecular & Cellular Biology

Theses from 2013 2013

Characterizing the Heavy Metal Chelator, Tpen, as a Ca2+ Tool in the Mammalian Oocyte , Robert A. Agreda Mccaughin, Molecular & Cellular Biology

Sustainable Biofuels Production Through Understanding Fundamental Bacterial Pathways Involved in Biomass Degradation and Sugar Utilization , James CM Hayes, Molecular & Cellular Biology

Stiffness and Modulus and Independent Controllers of Breast Cancer Metastasis , Dannielle Ryman, Molecular & Cellular Biology

Theses from 2012 2012

The Pyrethroid Deltamethrin, Which Causes Choreoathetosis with Salivation (CS-Syndrome), Enhances Calcium Ion Influx via Phosphorylated CaV2.2 expresssed in Xenopus laevis oocytes , Anna-maria Alves, Molecular & Cellular Biology

A Test of the Hypothesis That Environmental Chemicals Interfere With Thyroid Hormone Action in Human Placenta , Katherine Geromini, Molecular & Cellular Biology

Analyzing the Role of Reactive Oxygen Species in Male-Female Interactions in Arabidopsis thaliana. , Eric A. Johnson, Molecular & Cellular Biology

Rhythmic Growth And Vascular Development In Brachypodium Distachyon , Dominick A. Matos, Molecular & Cellular Biology

Polymer Prodrug Conjugation to Tumor Homing Mesenchymal Stem Cells , Nick Panzarino, Molecular & Cellular Biology

Investigation of Differential Vector Competence of Bartonella quintana in Human Head and Body Lice , Domenic j. Previte, Molecular & Cellular Biology

Downregulation of Cinnamyl Alcohol Dehydrogenase or Caffeic Acid O-Methyltransferase Leads to Improved Biological Conversion Efficiency in Brachypodium distachyon , Gina M. Trabucco, Molecular & Cellular Biology

Theses from 2011 2011

Evolutionary Relationship of the ampC Resistance Gene In E. cloacae , Shanika S. Collins, Molecular & Cellular Biology

Sex Difference in Calbindin Cell Number in the Mouse Preoptic Area: Effects of Neonatal Estradiol and Bax Gene Deletion , Richard F. Gilmore III, Molecular & Cellular Biology

In Vivo Investigations of Polymer Conjugates as Therapeutics , Elizabeth M. Henchey, Molecular & Cellular Biology

Examination of Sexually Dimorphic Cell Death in the Pubertal Mouse Brain , Amanda Holley, Molecular & Cellular Biology

Human Niemann-Pick Type C2 Disease Protein Expression, Purification and Crystallization , Yurie T. Kim, Molecular & Cellular Biology

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Progress Towards A Model Flavoenzyme System , Kevin M. Bardon, Molecular & Cellular Biology

The effect of Rhodiola crenulata on a highly metastatic murine mammary carcinoma , Jessica L. Doerner, Molecular & Cellular Biology

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• v.36(2); 2017 Apr

Language: English | Serbian

Medical Biochemistry as Subdiscipline of Laboratory Medicine in Serbia

Medicinska biohemija kao grana laboratorijske medicine u srbiji, snežana jovičić.

1 Society of Medical Biochemists of Serbia, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia

Nada Majkić-Singh

Medical biochemistry is the usual name for clinical biochemistry or clinical chemistry in Serbia, and medical biochemist is the official name for the clinical chemist (or clinical biochemist). This is the largest sub-discipline of the laboratory medicine in Serbia. It includes all aspects of clinical chemistry, and also laboratory hematology with coagulation, immunology, etc. Medical biochemistry laboratories in Serbia and medical biochemists as a profession are part of Health Care System and their activities are regulated through: the Health Care Law and rules issued by the Chamber of Medical Biochemists of Serbia. The first continuous and organized education for Medical Biochemists (Clinical Chemists) in Serbia dates from 1945, when the Department of Medical Biochemistry was established at the Pharmaceutical Faculty in Belgrade. In 1987 at the same Faculty a five years undergraduate study program was established, educating Medical Biochemists under a special program. Since the academic year 2006/2007 the new five year undergraduate (according to Bologna Declaration) and four-year postgraduate program according to EC4 European Syllabus for Postgraduate Training in Clinical Chemistry and Laboratory Medicine has been established. The Ministry of Education and Ministry of Public Health accredited these programs. There are four requirements for practicing medical biochemistry in the Health Care System: University Diploma of the Faculty of Pharmacy (Study of Medical Biochemistry), successful completion of the professional exam at the Ministry of Health after completion of one additional year of obligatory practical training in the medical biochemistry laboratories, membership in the Serbian Chamber of Medical Biochemists and licence for skilled work issued by the Serbian Chamber of Medical Biochemists. In order to present laboratory medical biochemistry practice in Serbia this paper will be focused on the following: Serbian national legislation, healthcare services organization, sub-disciplines of laboratory medicine and medical biochemistry as the most significant, education in medical biochemistry, conditions for professional practice in medical biochemistry, continuous quality improvement, and accreditation. Serbian healthcare is based on fundamental principles of universal health coverage and solidarity between all citizens.

Kratak sadržaj

Medicinska biohemija je uobičajeni naziv za kliničku biohemiju ili kliničku hemiju u Srbiji i medicinski biohemičar je uobičajeni naziv za kliničkog hemičara (ili klinickog biohemičara). Ovo je najveća pod-disciplina laboratorijske medicine u Srbiji. Uključuje sve aspekte kliničke hemije, kao i laboratorijske hematologije sa koagulacijom, imunologijom itd. Medicinsko-biohemijske laboratorije u Srbiji i medicinski biohemičari kao profesija su deo zdravstvenog sistema u njihova aktivnost je regulisana: Zakonom o zdravstvenoj zaštiti, i pravilima Komore biohemičara u Srbiji. Prva kontinuirana i organizovana edukacija medicinskih biohemičara (kliničkih hemičara) u Srbiji datira još iz 1945. godine, kada je otvoren Zavod za medicinsku biohemiju na Farmaceutskom fakultetu u Beogradu. Godine 1987. na istom Fakultetu uvedeno je petogodišnje obrazovanje medicinskih biohemičara po specijalnom programu studija. Počev od školske 2006/2007 uveden je novi petogodišnji program studija prema Bolonjskoj deklaraciji, kao i četvorogodišnje specijalističko obrazovanje prema EC-4 European Syllabus for Postgraduate Training in Clinical Chemistry and Laboratory Medicine. Ovi programi su akreditovani kod Minstarstva prosvete i zdravlja. Prema Zakonu o zdravstvenoj zaštiti postoje četiri zahteva za obavljanje medicinske biohemije: univerzitetska dioploma Farmaceutskog fakulteta (studije medicinske biohemije), uspešno položen stručni ispit u Ministarstvu zdravlja nakon obavljenja prakse u laboratoriji prema utvrđenom programu, članstvo u Komori biohemičara Srbije, kako i licenca o obavljanju delatnosti Komore biohemičara Srbije. Kako bi se praksa laboratorijske medicine-medicinske biohemije prezentovala ovaj rad će se baviti sledećim: srpskom nacionalnom legislativom, organizacijom zdravstvene službe, pod-diciplinama laboratorijske medicine i medicinskom biohemijom kao najznačajnijom granom iste, edukacijom medicinskih biohemičara, uslovima obavljanja profesionalne prakse, stalnim poboljšanjem kvaliteta i akreditacijom laboratorija. Srpski zdravstveni sistem se zasniva na fundamentalnim principima univerzalnog pokrivanja zdravstvene zaštite na principima solidarnosti među građanima.

Introduction

Medical biochemistry is the usual name for clinical biochemistry or clinical chemistry in Serbia, and medical biochemist is the official name for the clinical chemist (or clinical biochemist). This is the largest sub-discipline of the laboratory medicine in Serbia. It includes all aspects of clinical chemistry, and also laboratory hematology with coagulation, immunology, etc. Medical biochemistry laboratories in Serbia and medical biochemists as a profession are part of Health Care System and their activities are regulated through: the Health Care Law and regulations issued by the Chamber of Medical Biochemists of Serbia.

The beginning of continuous and organized education for Medical Biochemists (Clinical Chemists) in Serbia dates from 1945, when the Department of Medical Biochemistry was established at the Faculty of Pharmacy University of Belgrade. In 1987, a separate, four year medical biochemistry study program was started, and in 1991 it evolved in a five years undergraduate study program in medical biochemistry. Since the academic year 2006/2007 the five year undergraduate study program has been adjusted to meet the principles of the Bologna Declaration and postgraduate program of four-year specialization according to EC4 European Syllabus for Post-Graduate Training in Clinical Chemistry and Laboratory Medicine has been established. The Ministry of Education and Ministry of Public Health accredited these programs.

Four requirements for practicing medical biochemistry have been defined in the Health Care System of the Republic of Serbia: University Diploma of the Faculty of Pharmacy (Studies of Medical Biochemistry), successful completion of the professional exam at the Ministry of Health after completion of one year of residency training in the medical biochemistry laboratories, membership in the Chamber of Medical Biochemists of Serbia and licence for skilled work issued by the Chamber ( 1 – 4 ).

In order to present laboratory medicine practice in Serbia this paper will be focused on the following: Serbian national legislation, healthcare services organization, sub-disciplines of laboratory medicine and medical biochemistry as the most significant, education in medical biochemistry, conditions for professional practice in medical biochemistry, continuous quality improvement, and accreditation. Serbian healthcare is based on fundamental principles of universal health coverage and solidarity between all citizens ( 5 – 7 ).

Serbian National Legislation

Serbian National Legislation consists of the Healthcare Law of the Republic of Serbia, Guidelines on closer terms of providing healthcare in health centers and other healthcare institutions, Guidelines on internal organization of healthcare institutions, Guidelines on files and medical documentation, staff reports, equipment, rooms, and medicines in healthcare institutions, expert methodological instructions for the work and organization of medical biochemistry laboratory service, Law on standardization, Guidelines on healthcare quality indicators, Law on safety at work, etc. ( 5 , 6 ).

Funding of Healthcare in the Republic of Serbia is designed basically on the Bismarck’s model of the social insurance since more than 90% of resources for the realization of rights from the mandatory health insurance are provided from the contribution of citizens for mandatory health insurance. However, the Healthcare law also implies financing from the budget of the Republic for persons not included in mandatory health insurance (unemployed, refugees, persons on wellfare, etc.) which is the feature of the Beveridge model. So, we may say that in Serbia we have the combined financing system from almost exclusively public sources – contributions and the state’s budget. Serbia allocates >10% of GDP per capita for healthcare, which is above the EU average (according to the WHO), but these resources are small because of the relatively low level of GDP in Serbia. The latest statistics shows that the GDP in Serbia in 2016 was ~4500 € per capita, out of which to healthcare was allocated ~450 € ( 8 , 9 ).

Healthcare institutions are organized as ambulatory and hospital care in the public sector. Health insurance rights are ensured through National Health Insurance Fund. Healthcare law in its Article 1 states that the law governs the healthcare system of the Republic of Serbia, the organization of the health service, social care for the health of the population, general interest in healthcare, supervision of its implementation, as well as other matters of significance for the organization and provision of healthcare. Article 2 defines that the healthcare, in terms of this law, is an organized and comprehensive activity of the society, aimed at achieving the highest possible level of preserving the health of the citizens and family. Healthcare includes implementation of measures and activities for preserving and improving the health of the citizens of Republic of Serbia, for the prevention, suppression, and early discovery of disease,injuries, and other health disturbances, and timely, efficient and effective treatment, care, and rehabilitation.The right to healthcare have every citizen of Republic of Serbia, and every foreign citizen or person without citizenship who is permanently or temporarily residing in the Republic of Serbia or is passing through the territory of the Republic of Serbia. They have the right to healthcare, according to law, and a duty to preserve and improve their health and the health of all other citizens, as well as the living and working environment conditions ( Article 3 ) (5) .

Healthcare implementation is enabled through three levels of professional organization: primary level is represented by health centers; facilities of the secondary level are general and specialized hospitals; tertiary level is provided at clinics, clinical hospital centers or clinical center. There are some healthcare services provided at several levels, like blood banking or forensic medicine (see Table I and Table II ).

Health Care Organization in Serbia (9) .

Health care organization in Serbia – hospital beds (10) .

Laboratory Medicine – Medical Biochemistry

The term laboratory medicine covers medical biochemistry (clinical chemistry), laboratory hematology, microbiology, immunology, immunohematology analysis, toxicology analysis, cytogenetics and molecular genetics, tissue typing, and histopathology. Medical biochemistry is the synonym for clinical chemistry in Serbia, and it includes all aspects of clinical chemistry, laboratory hematology with coagulation, immunochemistry, and laboratory endocrinology.

Medical Biochemistry is a common term for clinical chemistry or clinical biochemistry since 1939, and professional name for the clinical biochemist or clinical chemist is medical biochemist. It is the the largest sub-discipline of laboratory medicine ( 1 , 7 , 11 ). More than 1500 laboratory parameters of the 3000 defined in the National Nomenclature for various sub-disciplines of laboratory medicine are processed in medical biochemistry laboratories. Medical biochemistry laboratory diagnostics is performed in an appropriate scope according to the level of healthcare (primary, secondary, tertiary) as regulated by the Nomenclature of Laboratory Services (12) . Guidelines on the Nomenclature of laboratory healthcare services determine the Nomenclature of laboratory healthcare services at the primary, secondary and tertiary level of healthcare, and they have been applied since 1 July 2012. The extracts from the official Nomenclature of healthcare services with the level of healthcare where the particular service should be available are shown on Tables III and ​ IV IV . Firstly the common general laboratory services, like blood sampling (micro sampling) and venipuncture, with the description of service are listed. The same is for all biochemical tests in blood, like presented in Table IV , serum, plasma, and all other types of samples, as well as for all other tests covered with the term laboratory medicine. The POCTs are also distinguished.

Nomenclature of Laboratory Medicine tests in Serbia (common laboratory services examples).

Nomenclature of Laboratory Medicine tests in Serbia (specific laboratory tests by separate branches examples).

Education in Medical Biochemistry

Considering the education in medical biochemistry, in Serbia, organized university education in Medical Biochemistry dates from the year 1945 when the Institute of Medical Biochemistry was founded at the Faculty of Pharmacy, University of Belgrade. In the year 1955, additional three years healthcare specialization in Medical Biochemistry was introduced. Then, in 1987, a separate four-year Medical Biochemistry study program was introduced, and in 1991, it evolved in a five-year study program in Medical Biochemistry. In 2006/2007, the five-year study program was adjusted to meet the principles of the Bologna Declaration ( 12 – 17 ).

Medical Biochemistry study program at the Faculty of Pharmacy is an integrated academic course lasting five academic years, i.e. 10 semesters. It brings 300 ECTS (European Credit Transfer System) credits and ends with writing a thesis and its oral defense. Upon graduation, the title Master of Pharmacy – Medical Biochemist is obtained. The program has been developed so as to train students to provide healthcare services in medical biochemistry laboratories, toxicology and sanitary laboratories. Creative work and research in medical biochemistry requires broad formal training in basic natural sciences and medicine and extensive laboratory experience. During the course of these 10 semesters studies Pharmacy-Medical Biochemistry, medical biochemist develop skills for laboratory work in three branches: medical biochemistry, toxicology, sanitary chemistry, use of laboratory methods and equipment, quality control of all working processes, patients and laboratory staff safety, etc. (15) .

Education outline in Medical Biochemistry.

Medical biochemists in Serbia in comparison to EC4 Register Standard.

In the course of education, a student is expected to acquire knowledge on: human organism, disease, role of biochemical laboratory in diagnostics and health care system. In the course of the study, a student is expected to acquire abilities and skills for: laboratory work, quality control that assures continuous process of checking and assessment measuring values to obtain reliable result and medicinally relevant information, handling with instruments and equipments, protection of laboratory staff and safe handling with chemicals and biological materials as well as pharmaceutical/medicinal waste.

Postgraduate education in Medical Biochemistry can be achieved through specialist program and doctoral academic studies. A 3-year specialist program in medical biochemistry existed from 1953 until 2006. After coordination with the European legislation and EC4 European Syllabus for Postgraduate Training in Clinical Chemistry and Laboratory Medicine, a four-year Medical Biochemistry Specialist program was prepared. The Faculty of Pharmacy in Belgrade organizes the specialization studies in the health care area in accordance with the Health Protection Act of the Republic of Serbia. However, in order to enroll in this course one should get the approval of Serbian Ministry of Health, on the basis of the request from the director of the organization in which applicant medical biochemists works, and according the Rules and regulations: on the health care specialization studies ( www. pharmacy.bg.ac.rs ).

Additionally, for Medical Biochemistry Specialists, three one year sub-specializations programs are available in Clinical Enzymology, Laboratory Endocrinology, and Clinical Immunochemistry. They all end with writing a thesis and its oral defense. Besides the education at the Faculty of Pharmacy, in medical biochemistry laboratories work medical doctors with the specialization in Clinical Biochemistry. These specialization studies at the Faculty of Medicine last for three years, after which the professional title of Specialist in Clinical Biochemistry is obtained. Although the syllabuses of specializations in medical biochemistry at the Faculty of Pharmacy and in clinical biochemistry at the Faculty of Medicine are not equivalent, these two specialists are equal according to the Healthcare Law. Either education of medical biochemists/clinical biochemists of Serbia is equivalent with EC4 Register Standard (18) .

The Faculty of Pharmacy in Belgrade organizes the doctoral academic studies (PhD). Medical Biochemistry is one of the doctoral studies moduls. These studies last for three years, i.e. six semesters with total of 180 ECTS credits. A student who completes the PhD academic studies acquires the scientific title Doctor of Medical Science – Pharmacy (Doctor of Pharmaceutical Science). The purpose of this study programme is to allow the students who have met the necessary requirements and who show affinities both toward scientific reasearch and systematic understanding of particular areas of medical biochemistry to master skills and methods of reasearch in given areas in order to be competent for future individual reasearch work. The purporse of this programme is to create new scientific-research oriented young generations of reasearchers who would reach new boundaries within their specific areas of interest during their professional careere, improve reasearch and teaching methods and become competent mentors to students of undergraduate, graduate and PhD studies ( 11 , 16 , 17 ).

Conditions for professional practice in Medical Biochemistry

On seven million residents of Serbia, we have 261 state laboratories, and 193 private laboratories registered at the Chamber of Biochemists of Serbia. In these laboratories work 295 Masters of Pharmacy- Medical Biochemists, 227 Medical Biochemistry Specialists (graduated at the Faculty of Pharmacy), and 276 Clinical Biochemistry Specialists, which are Doctors of Medicine. In total, there are 798 biochemists of either specialization. Also, there are around 150 Scientists (chemists, biologists, etc.) who are unlicensed, 37 Masters of Science, 47 PhDs, and 48 Primaries.

Medical Biochemists and Medical Biochemistry as a profession in Serbia are part of the healthcare system whose position is regulated by Healthcare Law of the Republic of Serbia, Law on Chambers of health workers, and Guidelines of the Ministry of Health and the Chamber of Biochemists of Serbia. Medical biochemistry laboratories are an integral part of healthcare facilities of appropriate level organized depending on the level of healthcare (primary, secondary, tertiary) and according to the Guidelines for Providing Healthcare and Guidelines on Conditions for Providing Healthcare. According to the number and complexity of the tests performed as well as to the qualifications of the laboratory personnel in the medical biochemistry laboratories may be: General (in a primary healthcare setting), Specialized (in a general hospital), Subspecial (in a specialized hospital or clinical hospital center), and Clinical (in an University clinical center). Clinical medical biochemistry laboratories as parts of the University hospitals are a teaching units for undergraduate and postgraduate education of medical biochemists. Private laboratories are either general or special laboratories. All medical biochemistry laboratories and the list of tests performed are licenced through the Ministry of Health. Nomenclature of services defines the level of performance in the field of Medical Biochemistry ( 5 , 12 ).

According to the Guidelines for Providing Healthcare and Guidelines on Conditions for Providing Healthcare in medical biochemistry laboratory must work at least one medical biochemists on 120.000 analysis performed, and one technician on 20.000 analysis performed per year ( 5 , 6 ).

There are four requirements for practicing medical biochemistry in the Serbian Healthcare System:

• University Diploma of the Faculty of Pharmacy (Studies of Medical Biochemistry),
• Successful completion of the professional exam at the Ministry of Health after completion of one year of residency training (interim) in the medical biochemistry laboratories,
• Membership in the Chamber of Medical Biochemists of Serbia,
• Professional Licence for skilled work in healthcare practice issued by the Chamber of Medical Biochemists of Serbia

Chamber of Biochemists of Serbia was founded in 2006 according to the Healthcare Law. The law states that licenses should be renewed every 7 years, based on successful completion of Continuous Medical Education (CME) ( The Rules of Continuing Education of Medical Biochemists issued by the Chamber of Medical Biochemists ( www.komorabiohemsrbije.org.rs ). These programs may be offered by University Faculties (Pharmacy, Medicine), professional associations (Societies), individuals, etc. (19) .

Very important role in Continuous Medical Education has the Society of Medical Biochemists of Serbia that offers different programs of CME. The Society of Medical Biochemists of Serbia ( www.dmbj.org.rs ) was established in 1955, and since its institution until these days, the Society has accomplished significant activities in the field of education of medical biochemists through the organization of congresses (biannually), Days of Biochemistry (annual), Innovations in laboratory medicine (annual), Congresses of Balkan Clinical Laboratory Federation, Scientific Conference »Professor Ivan Berkes« (annual), EFCC Symposium for Balkan Region, Educational seminars, etc. The Society has significant publishing activity through Journal of Medical Biochemistry ( www.dmbj.org.rs ) and professional-methodological guidebooks for the field of medical biochemistry.

On Figures 2 and ​ and3 3 the web page of the Society of Medical Biochemists of Serbia with the cover page of its official journal – Journal of Medical Biochemistry, the member of COPE, EASE, and WAME are presented.

Cover page of the Society Medical Biochemits website ( www.dmbj.org.rs )

The Society of Medical Biochemists of Serbia gathers medical biochemists in promoting and developing the profession in the provision of healthcare. The tasks of the Society include achieving uniform work standards in medical biochemistry laboratories, providing continuous education for medical biochemists at all academic levels, instigating scientific/research activities, establishing work norms and emphasizing the code of ethics of healthcare workers. The members of the Society have participated in the preparation of series of expert guidelines in the field of Medical Biochemistry that may be delivered to Serbian Ministry of Health in respect of laboratory organization, and all other laboratory standards. Also, the Society is engaged in important publishing activities.

Continues Quality Improvement of Laboratory Service in Serbia

At the national level, all stages of laboratory work will be subjected to standardization by the implementation of a Total Quality Management System (TQM), external and internal control of the quality of work, and good medical laboratory practice which ensures that laboratories will issue accurate and valid results (20) . This calls for conducting continuous quality improvement. There are some specific segments important for control of the work of medical biochemistry laboratories related to analytical procedures used.

The activities of the laboratory/laboratory service are clearly defined, from qualified staff, laboratory procedures through appropriate space and equipment, to LIS, quality and safety. Patient is provided a service by the laboratory/laboratory service provided by adequately qualified staff. There are procedures and guidelines for providing services within the laboratory/laboratory service. Laboratory/laboratory service is organized in an appropriate space. The equipment meets all the requirements for providing services in a laboratory/laboratory service. Information system is in the function of efficient delivery of laboratory services. Laboratory/laboratory service monitors the quality of work and the safety of patients, etc. ( 21 – 23 ).

SNEQAS-Serbian National External Quality Assessment Scheme is the member of the European Organization for External Quality Assurance Programs in Laboratory Medicine (EQALM). It is conducted by the Society of Medical Biochemists of Serbia – Commission for Quality Control and Accreditation via Center for Medical Biochemistry of the Clinical Center of Serbia. It is conducted twice a year, and it is aimed to control biochemical parameters. Around 300 medical biochemistry laboratories are included from the territory of the Republic of Serbia.

The medical laboratories in Serbia are subject of accreditation since 1999. The Accreditation Body of Serbia (ATS) as the national accreditation body was founded by the Republic of Serbia and is located in Belgrade. Pursuant to the Law on Accreditation, ATS has a task to assess the competence of conformity assessment bodies (CABs) to perform testing, calibration, inspection, and certification of products, management systems and persons. In the process of accreditation of healthcare institutions that will be conducted by the Agency for Accreditation of Healthcare Institutions of Serbia , one of the requirements for accreditation is the assessment of the work of laboratory service, which will be made on the basis of standards and criteria that have been specifically developed to meet the needs of all types of laboratories. In preparation of standards for accreditation of laboratory service in healthcare institutions that will be conducted by the Agency for Accreditation of Healthcare Institutions of Serbia, the members of the Society of Medical Biochemists of Serbia and Chamber of Biochemists of Serbia took very important role. So far, in Serbia, ATS has accredited 25 medical biochemistry laboratories, 12 as competent according to SRPS ISO 15189 and 13 according to SRPS ISO 17025. Agency for Accreditation of Healthcare Institutions accredited 190 medical laboratories as integral parts of their corresponding healthcare institutions.

We may conclude that in Serbia, the term laboratory medicine is practicaly equal with the medical biochemistry (as the synonym of clinical chemistry/ clinical biochemistry). Medical biochemistry laboratories are integral part of healthcare institutions to which they provide laboratory services, and the scope of their performance depends on the level of the belonging institution. Education of laboratory medicine professionals is equivalent with the EC4 register standards and every aspect of medical biochemistry laboratories performance is regulated by law and acompanying guidelines. In professional development, leading role belongs to the Society of Medical Biochemists of Serbia and Chamber of Biochemists of Serbia, and continuous quality improvement is ensured through the process of accreditation.

Conflict of interest statement : The authors stated that they have no conflicts of interest regarding the publication of this article.