Introduction to Sensitivity Analysis

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  • Bertrand Iooss 4 , 5 &
  • Andrea Saltelli 6 , 7  

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Sensitivity analysis provides users of mathematical and simulation models with tools to appreciate the dependency of the model output from model input and to investigate how important is each model input in determining its output. All application areas are concerned, from theoretical physics to engineering and socio-economics. This introductory paper provides the sensitivity analysis aims and objectives in order to explain the composition of the overall “Sensitivity Analysis” chapter of the Springer Handbook. It also describes the basic principles of sensitivity analysis, some classification grids to understand the application ranges of each method, a useful software package, and the notations used in the chapter papers. This section also offers a succinct description of sensitivity auditing, a new discipline that tests the entire inferential chain including model development, implicit assumptions, and normative issues and which is recommended when the inference provided by the model needs to feed into a regulatory or policy process. For the “Sensitivity Analysis” chapter, in addition to this introduction, eight papers have been written by around twenty practitioners from different fields of application. They cover the most widely used methods for this subject: the deterministic methods as the local sensitivity analysis, the experimental design strategies, the sampling-based and variance-based methods developed from the 1980s, and the new importance measures and metamodel-based techniques established and studied since the 2000s. In each paper, toy examples or industrial applications illustrate their relevance and usefulness.

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Industrial Risk Management Department, EDF R&D, Chatou, France

Bertrand Iooss

Institut de Mathématiques de Toulouse, Université Paul Sabatier, Toulouse, France

Centre for the Study of the Sciences and the Humanities (SVT), University of Bergen (UIB), Bergen, Norway

Andrea Saltelli

Institut de Ciència i Tecnologia Ambientals (ICTA), Universitat Autonoma de Barcelona (UAB), Barcelona, Spain

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Los Alamos National Laboratory, Los Alamos, New Mexico, USA

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California Institute of Technology , Pasadena, California, USA

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Iooss, B., Saltelli, A. (2015). Introduction to Sensitivity Analysis. In: Ghanem, R., Higdon, D., Owhadi, H. (eds) Handbook of Uncertainty Quantification. Springer, Cham. https://doi.org/10.1007/978-3-319-11259-6_31-1

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DOI : https://doi.org/10.1007/978-3-319-11259-6_31-1

Received : 20 December 2014

Accepted : 24 June 2015

Published : 26 March 2016

Publisher Name : Springer, Cham

Online ISBN : 978-3-319-11259-6

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Wan, Din Wan Ibrahim. "Sensitivity analysis intolerance allocation." Thesis, Queen's University Belfast, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.675480.

Poveda, David. "Sensitivity analysis of capital projects." Thesis, University of British Columbia, 1988. http://hdl.handle.net/2429/27990.

Faria, Jairo Rocha de. "Second order topological sensitivity analysis." Laboratório Nacional de Computação Científica, 2008. http://www.lncc.br/tdmc/tde_busca/arquivo.php?codArquivo=141.

Witzgall, Zachary F. "Parametric sensitivity analysis of microscrews." Morgantown, W. Va. : [West Virginia University Libraries], 2006. https://eidr.wvu.edu/etd/documentdata.eTD?documentid=4892.

鄧國良 and Kwok-leong Tang. "Sensitivity analysis of bootstrap methods." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1993. http://hub.hku.hk/bib/B31977479.

Fang, Xinding S. M. Massachusetts Institute of Technology. "Sensitivity analysis of fracture scattering." Thesis, Massachusetts Institute of Technology, 2010. http://hdl.handle.net/1721.1/59789.

Masinde, Brian. "Birds' Flight Range. : Sensitivity Analysis." Thesis, Linköpings universitet, Institutionen för datavetenskap, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-166248.

Tang, Kwok-leong. "Sensitivity analysis of bootstrap methods." [Hong Kong] : University of Hong Kong, 1993. http://sunzi.lib.hku.hk/hkuto/record.jsp?B13793792.

Munster, Drayton William. "Sensitivity Enhanced Model Reduction." Thesis, Virginia Tech, 2013. http://hdl.handle.net/10919/23169.

Konarski, Roman. "Sensitivity analysis for structural equation models." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/nq22893.pdf.

Sulieman, Hana. "Parametric sensitivity analysis in nonlinear regression." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape15/PQDD_0004/NQ27858.pdf.

Yu, Jianbin. "Flexible reinforced pavement structure-sensitivity analysis." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape3/PQDD_0015/MQ52682.pdf.

Kolen, A. W. J., Kan A. H. G. Rinnooy, Hoesel C. P. M. Van, and Albert Wagelmans. "Sensitivity Analysis of List Scheduling Heuristics." Massachusetts Institute of Technology, Operations Research Center, 1990. http://hdl.handle.net/1721.1/5268.

Maginot, Jeremy. "Sensitivity analysis for multidisciplinary design optmization." Thesis, Cranfield University, 2007. http://dspace.lib.cranfield.ac.uk/handle/1826/5667.

North, Simon John. "High sensitivity mass spectrometric glycoprotein analysis." Thesis, Imperial College London, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.404993.

Maginot, Jeremy. "Sensitivity analysis for multidisciplinary design optimization." Thesis, Cranfield University, 2007. http://dspace.lib.cranfield.ac.uk/handle/1826/5667.

Johnson, Timothy J. "Sensitivity analysis of transputer workfarm topologies." Thesis, Monterey, California. Naval Postgraduate School, 1989. http://hdl.handle.net/10945/27258.

Khan, Kamil Ahmad. "Sensitivity analysis for nonsmooth dynamic systems." Thesis, Massachusetts Institute of Technology, 2015. http://hdl.handle.net/1721.1/98156.

Saxena, Vibhu Prakash. "Sensitivity analysis of oscillating hybrid systems." Thesis, Massachusetts Institute of Technology, 2010. http://hdl.handle.net/1721.1/61899.

Siannis, Fotios. "Sensitivity analysis for correlated survival models." Thesis, University of Warwick, 2001. http://wrap.warwick.ac.uk/78861/.

Santos, Miguel Duque. "UK pension funds : liability sensitivity analysis." Master's thesis, Instituto Superior de Economia e Gestão, 2019. http://hdl.handle.net/10400.5/19509.

Sen, Sharma Pradeep Kumar. "Sensitivity analysis of ship longitudinal strength." Thesis, Virginia Tech, 1988. http://hdl.handle.net/10919/45183.

DeBrunner, Victor Earl. "Sensitivity analysis of digital filter structures." Thesis, Virginia Polytechnic Institute and State University, 1986. http://hdl.handle.net/10919/104319.

Wycoff, Nathan Benjamin. "Gradient-Based Sensitivity Analysis with Kernels." Diss., Virginia Tech, 2021. http://hdl.handle.net/10919/104683.

Kern, Simon. "Sensitivity Analysis in 3D Turbine CFD." Thesis, KTH, Mekanik, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-210821.

Issac, Jason Cherian. "Sensitivity analysis of wing aeroelastic responses." Diss., This resource online, 1995. http://scholar.lib.vt.edu/theses/available/etd-06062008-164301/.

Kennedy, Christopher Brandon. "GPT-Free Sensitivity Analysis for Reactor Depletion and Analysis." Thesis, North Carolina State University, 2015. http://pqdtopen.proquest.com/#viewpdf?dispub=3710730.

Introduced in this dissertation is a novel approach that forms a reduced-order model (ROM), based on subspace methods, that allows for the generation of response sensitivity profiles without the need to set up or solve the generalized inhomogeneous perturbation theory (GPT) equations. The new approach, denoted hereinafter as the generalized perturbation theory free (GPT-Free) approach, computes response sensitivity profiles in a manner that is independent of the number or type of responses, allowing for an efficient computation of sensitivities when many responses are required. Moreover, the reduction error associated with the ROM is quantified by means of a Wilks’ order statistics error metric denoted by the κ-metric.

Traditional GPT has been recognized as the most computationally efficient approach for performing sensitivity analyses of models with many input parameters, e.g. when forward sensitivity analyses are computationally overwhelming. However, most neutronics codes that can solve the fundamental (homogenous) adjoint eigenvalue problem do not have GPT (inhomogenous) capabilities unless envisioned during code development. Additionally, codes that use a stochastic algorithm, i.e. Monte Carlo methods, may have difficult or undefined GPT equations. When GPT calculations are available through software, the aforementioned efficiency gained from the GPT approach diminishes when the model has both many output responses and many input parameters. The GPT-Free approach addresses these limitations, first by only requiring the ability to compute the fundamental adjoint from perturbation theory, and second by constructing a ROM from fundamental adjoint calculations, constraining input parameters to a subspace. This approach bypasses the requirement to perform GPT calculations while simultaneously reducing the number of simulations required.

In addition to the reduction of simulations, a major benefit of the GPT-Free approach is explicit control of the reduced order model (ROM) error. When building a subspace using the GPT-Free approach, the reduction error can be selected based on an error tolerance for generic flux response-integrals. The GPT-Free approach then solves the fundamental adjoint equation with randomly generated sets of input parameters. Using properties from linear algebra, the fundamental k-eigenvalue sensitivities, spanned by the various randomly generated models, can be related to response sensitivity profiles by a change of basis. These sensitivity profiles are the first-order derivatives of responses to input parameters. The quality of the basis is evaluated using the κ-metric, developed from Wilks’ order statistics, on the user-defined response functionals that involve the flux state-space. Because the κ-metric is formed from Wilks’ order statistics, a probability-confidence interval can be established around the reduction error based on user-defined responses such as fuel-flux, max-flux error, or other generic inner products requiring the flux. In general, The GPT-Free approach will produce a ROM with a quantifiable, user-specified reduction error.

This dissertation demonstrates the GPT-Free approach for steady state and depletion reactor calculations modeled by SCALE6, an analysis tool developed by Oak Ridge National Laboratory. Future work includes the development of GPT-Free for new Monte Carlo methods where the fundamental adjoint is available. Additionally, the approach in this dissertation examines only the first derivatives of responses, the response sensitivity profile; extension and/or generalization of the GPT-Free approach to higher order response sensitivity profiles is natural area for future research.

Guo, Jia. "Uncertainty analysis and sensitivity analysis for multidisciplinary systems design." Diss., Rolla, Mo. : Missouri University of Science and Technology, 2008. http://scholarsmine.mst.edu/thesis/pdf/Guo_09007dcc8066e905.pdf.

Ekberg, Marie. "Sensitivity analysis of optimization : Examining sensitivity of bottleneck optimization to input data models." Thesis, Högskolan i Skövde, Institutionen för ingenjörsvetenskap, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-12624.

Reineke, Jan. "Caches in WCET analysis : predictability, competitiveness, sensitivity /." Berlin : epubli, 2008. http://www.epubli.de/shop/showshopelement?pubId=882.

Chaban, Habib Fady Ruben. "A numerical sensitivity analysis of streamline simulation." Texas A&M University, 2004. http://hdl.handle.net/1969.1/1541.

Gajev, Ivan. "Sensitivity and Uncertainty Analysis of BWR Stability." Licentiate thesis, KTH, Kärnkraftsäkerhet, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-26387.

Nahum, Carole. "Second order sensitivity analysis in mathematical programming." Thesis, McGill University, 1989. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=74349.

Wu, QiongLi. "Sensitivity Analysis for Functional Structural Plant Modelling." Phd thesis, Ecole Centrale Paris, 2012. http://tel.archives-ouvertes.fr/tel-00719935.

braswell, tom. "SPACECRAFT LOADS PREDICTIONVIA SENSITIVITY ANALYSIS AND OPTIMIZATION." Master's thesis, University of Central Florida, 2007. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/3532.

Rios, Insua David. "Sensitivity analysis in multi-objective decision making." Thesis, University of Leeds, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.236870.

Yin, Peng. "Local sensitivity analysis and bias model selection." Thesis, University of Newcastle upon Tyne, 2014. http://hdl.handle.net/10443/2385.

Zhu, Yitao. "Sensitivity Analysis and Optimization of Multibody Systems." Diss., Virginia Tech, 2015. http://hdl.handle.net/10919/71649.

Svenson, Joshua. "Computer Experiments: Multiobjective Optimization and Sensitivity Analysis." The Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1306361734.

Hakami, Amir. "Direct sensitivity analysis in air quality models." Diss., Available online, Georgia Institute of Technology, 2004:, 2003. http://etd.gatech.edu/theses/available/etd-04082004-180202/unrestricted/hakami%5Famir%5F200312%5Fphd.pdf.

Garmroodi, Doiran Mehdi. "Sensitivity Analysis for Future Grid Stability Studies." Thesis, The University of Sydney, 2016. http://hdl.handle.net/2123/15978.

Tiscareno-Lopez, Mario 1957. "Sensitivity analysis of the WEPP Watershed model." Thesis, The University of Arizona, 1991. http://hdl.handle.net/10150/292034.

Capozzi, Marco G. F. "FINITE ELEMENT ANALYSIS AND SENSITIVITY ANALYSIS FOR THE POTENTIAL EQUATION." MSSTATE, 2004. http://sun.library.msstate.edu/ETD-db/theses/available/etd-04222004-131403/.

Rapadamnaba, Robert. "Uncertainty analysis, sensitivity analysis, and machine learning in cardiovascular biomechanics." Thesis, Montpellier, 2020. http://www.theses.fr/2020MONTS058.

Wang, Mengchao. "Sensitivity analysis and evolutionary optimization for building design." Thesis, Loughborough University, 2014. https://dspace.lboro.ac.uk/2134/16282.

Van, Hoesel Stan, and Albert Wagelmans. "Sensitivity Analysis of the Economic Lot-Sizing Problem." Massachusetts Institute of Technology, Operations Research Center, 1990. http://hdl.handle.net/1721.1/5146.

Barthelemy, Bruno. "Accuracy analysis of the semi-analytical method for shape sensitivity analysis." Diss., Virginia Polytechnic Institute and State University, 1987. http://hdl.handle.net/10919/74754.

Kobayashi, Izumi. "Sensitivity analysis of the topology of classification trees." Thesis, Monterey, Calif. : Springfield, Va. : Naval Postgraduate School ; Available from National Technical Information Service, 1999. http://handle.dtic.mil/100.2/ADA372965.

Kafali, Pinar. "Evaluation Of Sensitivity Of Metu Gait Analysis System." Master's thesis, METU, 2007. http://etd.lib.metu.edu.tr/upload/12608390/index.pdf.

Ezertas, Ahmet Alper. "Sensitivity Analysis Using Finite Difference And Analytical Jacobians." Master's thesis, METU, 2009. http://etd.lib.metu.edu.tr/upload/12611067/index.pdf.

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    sensitivity analysis thesis pdf

  3. (PDF) Sensitivity analysis for clinical trials with missing continuous

    sensitivity analysis thesis pdf

  4. Sensitivity analysis.

    sensitivity analysis thesis pdf

  5. What is Sensitivity Analysis?

    sensitivity analysis thesis pdf

  6. Sensitivity Analysis Definition

    sensitivity analysis thesis pdf

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  1. Sensitivity Analysis

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  1. PDF Sensitivity Analysis and Robust Optimization

    We achieve the goal of this thesis via sensitivity analysis. Sensitivity analysis tries to answer how sensitive the optimal value/solution is to small changes in one or more of the parameters/data of the original problem. We rst consider an uncertain linear programming and formulate its robust counterpart. We then show that the resulting robust

  2. PDF Introduction: Sensitivity Analysis

    policy process. For the \Sensitivity Analysis" chapter, in addition to this introduction, eight papers have been written by around twenty practitioners from di erent elds of application. They cover the most widely used methods for this subject: the determin-istic methods as the local sensitivity analysis, the experimental design strategies, the

  3. PDF Thesis Sensitivity Analysis of The Basic Reproduction Number and Other

    Sensitivity analysis tells the re-searcher which parameters in the model have the most in uence over a quantity of interest. Elasticity analysis is just a scaled version of this information based on the magnitudes of the parameters. Chapter 3 will de ne sensitivity and elasticity analysis for discrete and continuous systems.

  4. PDF Chapter 17 Sensitivity Analysis and Model Validation

    17.2.3 Sensitivity Analysis. Sensitivity analysis involves a series of methods to quantify how the uncertainty in the output of a model is related to the uncertainty in its inputs. In other words, sensitivity analysis assesses how sensitive the model is to uctuations in the. parameters and data on which it is built.

  5. Uncertainty and Sensitivity Analysis Methods for Improving Design

    Massachusetts Institute of Technology is a world-renowned research university that offers a variety of academic programs and disciplines. This webpage provides a PDF document that contains information about the history, mission, organization, and achievements of MIT, as well as some facts and figures about its students, faculty, and alumni.

  6. Error and Uncertainty Quantification and Sensitivity Analysis in

    Verification and validation are quantitative procedures to check how well the model represents the real world phenomenon being simulated. The accuracy of the

  7. (PDF) Introduction to Sensitivity Analysis

    Abstract. Sensitivity analysis provides users of mathematical and simulation models with tools to appreciate the dependency of the model output from model input and to investigate how important is ...

  8. PDF Sensitivity Analysis in Observational Research: Introducing the E-Value

    Sensitivity analysis for unmeasured confounding Sensitivity analysis considers how strong an unmeasured confounder would have to be related to the treatment and the outcome to explain away the observed association. Numerous sensitivity analysis techniques have been developed for different statistical models (14-22,24-40). Often

  9. PDF Introduction to Sensitivity Analysis

    regulatory or policy process. For the "Sensitivity Analysis" chapter, in addition to this introduction, eight papers have been written by around twenty practitioners from different fields of application. They cover the most widely used methods for this subject: the deterministic methods as the local sensitivity analysis, the

  10. Introduction to Sensitivity Analysis

    Abstract. Sensitivity analysis provides users of mathematical and simulation models with tools to appreciate the dependency of the model output from model input and to investigate how important is each model input in determining its output. All application areas are concerned, from theoretical physics to engineering and socio-economics.

  11. Sensitivity Analysis: A Method to Promote Certainty and Transparency in

    reported for the primary analysis (Morris et al., 2014). This type of sensitivity analysis is often carried out to test the val-idity of arbitrary or unclear decisions made following proto-col publication or data collection. For example, if there is uncertainty regarding the cut-off used to dene an exposure. fi.

  12. (PDF) Sensitivity Analysis

    PDF | On Jan 1, 2010, Andrea Saltelli and others published Sensitivity Analysis | Find, read and cite all the research you need on ResearchGate

  13. PDF A review of techniques for parameter sensitivity analysis of

    1.Introduction. Mathematical models reutilized to approximate various highly complex engi-neering, physical, environmental, sociandeconomic phenomena. Model devel-opment consists ofseveral logical steps, one of which is the determination of parameters which are most influential on model results. A 'sensitivity analysis' of these parameters is ...

  14. PDF MATLODE: A MATLAB ODE Solver and Sensitivity Analysis Toolbox

    Sensitivity analysis [11] quanti es the impact of input parameters onto the model's outcome. ... sensitivity analysis. 1.3 Outline of the Thesis This thesis is composed of four chapters. Chapter 1 discusses the general theory of forward integration solvers and sensitivity analysis. Chapter 2 describes the MATLAB software package

  15. PDF Global Sensitivity Analysis for Randomized Trials With Informative

    In this thesis, we develop a sensitivity analysis methodology for analyzing randomized trials with a potentially informative assessment process. We develop these methods in the context of the Asthma Research for the Community (ARC) trial. Primary Reader and Advisor: Daniel O. Scharfstein

  16. (PDF) The Future of Sensitivity Analysis: An Essential Discipline for

    'Sensitivity Analysis of Model Output' (SAMO), held once every three years since 1995 - the 9th instalment o f which was held in 2019 i n Barcelona, Spain, with the forthcomin g 10th

  17. PDF Sensitivity

    Master's Thesis The thesis completes a Master's degree in Economics University of Bergen, Department of Economics [June 2021] ii Acknowledgments ... The extensions are based on the principles of sensitivity analysis as suggested by Edward Leamer (1983) with the explicit goal of illustrating the possible uncertainty about the ...

  18. PDF Sensitivity analysis in clinical trials: three criteria for a valid

    Sensitivity analyses are important to perform in order to assess the robustness of the conclusions of the trial. It is critical to distinguish between sensitivity and supplementary or other ...

  19. Sensitivity Analysis: A Method to Promote Certainty and Transparency in

    Sensitivity analysis is a method used to evaluate the influence of alternative assumptions or analyses on the pre-specified research questions proposed (Deeks et al., 2021; Schneeweiss, 2006; Thabane et al., 2013).In other words, a sensitivity analysis is purposed to evaluate the validity and certainty of the primary methodological or analytic strategy.

  20. DataSpace: Generalized Methods for Global Sensitivity Analysis

    The primary focus of this thesis is to develop new data driven tools to analyze the input-outputinformation content of complex systems. The first advancement in this thesis is a new kernel-based global sensitivity analysis (GSA) methodology. The mathematical formulation of kernel GSA is developed and several key advantages are demonstrated over ...

  21. PDF Comparison of Life Cycle Analysis Methodologies and Practical

    Uncertainty and Sensitivity Analysis Outcome The uncertainty and sensitivity analysis was performed by varying four input parameters by equivalent percentages in both the base-level LCA model and the site level unit flow LCA model. The inputs that varied included: initial fiber blend weight, +/- 5%;

  22. [PDF] A tutorial on sensitivity analyses in clinical trials: the what

    When reporting on a clinical trial, it is recommended to include planned or posthoc sensitivity analyses, the corresponding rationale and results along with the discussion of the consequences of these analyses on the overall findings of the study. BackgroundSensitivity analyses play a crucial role in assessing the robustness of the findings or conclusions based on primary analyses of data in ...

  23. PDF Chapter 11. Sensitivity Analysis

    example is an "intention to treat" analysis that assumes that each participant continues to be exposed once they have received an initial treatment. Originally used in the analysis of randomized trials, this approach has been used in observational studies as well.6 It can be worthwhile to do a sensitivity analysis on studies that use an

  24. Dissertations / Theses: 'Sensitivity Analysis'

    Video (online) Consult the top 50 dissertations / theses for your research on the topic 'Sensitivity Analysis.'. Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA ...