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Current Issues, Challenges, and Future Perspectives in Clinical Laboratory Medicine

Ferdinando mannello.

1 Department of Biomolecular Sciences-DISB, University of Urbino Carlo Bo, 61029 Urbino, Italy

Mario Plebani

2 Department of Medicine-DIMED, University of Padua, 35128 Padua, Italy

Laboratory medicine has undergone a profound evolution in organizational, methodological, and cultural terms in recent decades [ 1 ]. From the organizational point of view, we are living in the era of consolidation, i.e., the formation of networks of consolidated laboratories with marked automation and integration of the various branches of laboratory medicine [ 2 ]. From a methodological point of view, the advent of high-throughput technologies has allowed us to launch a systematic approach to studying nucleic acids, proteins, and intermediate metabolites, all aspects that have considerably reduced the barriers between various branches of biology, to convey all of the information obtained (i.e., the so-called Big Data) into a new perspective of life science related to the biology of systems [ 3 ].

In this context, the “Omics” revolution, including mainly genomics, proteomics, degradomics, and metabolomics, has developed into the current major drivers of the bench-to-bedside passage of Omics without limiting the numerous other Omics that opened new and interesting perspectives in laboratory medicine and translational medicine (such as transcrittomics, mirnomics, epigenomics, interactomics, etc.) [ 4 ].

The enormous amount of data (“Big Data”) already obtained and still obtainable with Omics analyses have highlighted the professional nature of bioinformatics, opening new perspectives in studying crucial aspects of clinical laboratory medicine: the association–causality relationship; the management of results; the harmonization of data from different technological platforms; and ethical, legal, and privacy issues. Thanks to the use of Omics, clinical laboratory medicine will play a key role in significantly and substantially implementing precision medicine, in preventive screenings, in Omics diagnostics, in personalized drug treatments, and in clinical outcome monitoring.

Through the different Omics branches of clinical laboratory medicine, it will therefore be possible to develop innovative methods in diagnostics, the identification of new diagnostic and/or prognostic biomarkers, the development of innovative target-specific therapies, the design and construction of controlled clinical trials on new drugs, the drafting of new guidelines (such as those already carried out in the field of cardiovascular, hematological, and oncological diseases), as well as both the diagnostics and therapeutic treatments of several human pathologies. All of these crucial aspects are increasingly linked to the concept of well-being, including the application of Omics in laboratory medicine studies on the effects of physical exercise.

Clinical laboratory medicine will therefore change its paradigm, moving away from simple services for clinics and physicians and becoming an even more efficient reference for the diagnosis and treatment of patients [ 5 ].

The new diagnostic and therapeutic pathways offered by clinical laboratory medicine are mainly based on the three crucial aspects of appropriateness: prescription, analytics, and diagnostics. Prescriptive appropriateness provides physicians with a constant comparison with other laboratory colleagues to build the right diagnostic protocols. These joint protocols pave the way for feedback, with the best opportunities for updated investigations that the laboratory can offer to the patient, using the best choice of tests (diagnostic settings for personalized and precision medicine) [ 4 ].

Analytical appropriateness represents a fundamental part of the status of clinical laboratory medicine specialists as the search for even better technologies and possible new diagnostic tests (based on scientific evidence and surpassing the obsolete ones); this path allows us the best use of financial resources avoiding wasted costs and technologies, focusing efforts according to efficiency, expertise, and targeted epidemiological characteristics of the patient [ 5 ].

It is in this perspective that the diagnostic appropriateness must not only have an economic value for cost limitation but also an ethical value for the best diagnostic–therapeutic path of the patient.

Finally, diagnostic appropriateness is mainly aimed at improving clinical outcomes. Only in the face of a constant comparison between the treating physicians and the specialists of laboratory medicine will it be possible to understand the mantra “do the right test to the right patient at the right time and with the right specialist”: in this way, the expected results of diagnostic–therapeutic biomarkers will be obtained with the new Omic approaches of laboratory medicine [ 6 ].

If a health system with the patient at the center is oriented towards personalized and/or precision medicine, one cannot ignore appropriateness from a holistic perspective and therefore the indispensable involvement of specialists in laboratory medicine disciplines [ 5 ].

In this context, even the pharmaceutical and diagnostic industries can offer a substantial contribution to recovering efficiency and can ensure suitable results, supporting a paradigmatic shift. In fact, diagnostic appropriateness primarily means being able to choose technological innovation (both related to and not related to automation) and laboratory tests with new generation biomarkers on evidence-based medicine.

Importantly, diagnostic appropriateness is born from the definition of guidelines that identify the appropriate tests for a therapy of that type of patient with a specific pathology (and not misunderstanding appropriateness as a mere reduction in financial costs and medical prescriptions by limiting the choices of both clinicians and laboratory specialists in managing the patient’s health) [ 6 ].

The best indicator of appropriateness is the state of health that is reachable by the patient through innovation and technologies, simply evaluated in a timely and efficient manner according to a structured path of health technology assessment.

The specific application of guidelines, primary and secondary prevention interventions, initiative medicine and early diagnosis in subjects at risk, and management of chronic (pluri-pathological) patients are just some examples of appropriateness, i.e., appropriate application of health care for both healthy subjects and patients, and a correct interpretation of the holistic concept of health.

If the future of clinical laboratory medicine is precision and personalized medicine, we cannot ignore the appropriateness of diagnostic test requests and therefore the involvement of specialists in the disciplines of laboratory medicine areas in defining optimal diagnostic–therapeutic pathways for patient’s health [ 7 ].

On these bases, with great pleasure, we invite specialists from the various branches of laboratory medicine to participate in the submission of scientific work in the fields of clinical chemistry and translational medicine and from the full spectrum of clinical biochemistry and clinical laboratory medicine, promoting excellence in laboratory sciences and closely related fields and sub-specialties. We welcome contributions that will have an impact on the understanding of health and disease and on the progress in basic and applied research in clinical laboratory medicine, taking into consideration papers about all aspects of clinical chemistry and laboratory medicine, with a focus on analytical, preclinical, and clinical investigations of laboratory tests used for diagnosis, prognosis, treatment and therapy, and monitoring of disease in humans.

Welcome to the new “Clinical Laboratory Medicine” section ( https://www.mdpi.com/journal/jcm/sectioneditors/clinical_laboratory_medicine accessed on 26 January 2022).

Author Contributions

Conceptualization, M.P. and F.M.; writing—original draft preparation, F.M.; writing—review and editing, M.P. All authors have read and agreed to the published version of the manuscript.

This research received no external funding.

Institutional Review Board Statement

Not applicable.

Informed Consent Statement

Conflicts of interest.

The authors declare no conflict of interest.

Publisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations.

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Medical Lab Science and Tech

Medical lab science and tech research papers/topics, mutational signatures for breast cancer diagnosis using artificial intelligence.

Abstract Background Breast cancer is the most common female cancer worldwide. Its diagnosis and prognosis remain scanty, imprecise, and poorly documented. Previous studies have indicated that some genetic mutational signatures are suspected to lead to progression of various breast cancer scenarios. There is paucity of data on the role of AI tools in delineating breast cancer mutational signatures. This study sought to investigate the relationship between breast cancer genetic mutational prof...

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ABSTRACT Lemon grass (Cymbogon citratus) is an abundant, locally available plant. In this work, essential oil was extracted from it using solvent extraction method.  In this work two methods of extraction was used, solvent extraction and enfleurage methods were used to extract essential oil from lemongrass. Solvent extraction method yielded 2.08% and effleurage method yielded 1.96% essential oil respectively. From the analysis solvent extraction gave the highest yield because of the less e...

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Abstract  Human Immunodeficiency Virus ( HIV) is global and serious problem , with increase in mortality and morbidity worldwide. This was prospective , descriptive and cross sectional study aimed to assess the level of HIV Ab using the ICT and ELISA for detecting Ab and Ag (p24) .It was conducted among Screening patient in Khartoum state (National Public Health Laboratory) from 1 April to 30 June (2015) on a total of eighty nine (n=89)to compare the sensitivity and specificity of immunochro...

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Thermo Fisher Scientific

10 Life Science Trends to Watch in 2024

By Frances Gatta

From personalized medicine to lab automation to gene therapy, both established and emerging areas of innovation are set to help shape the future of the life sciences industry.

Let’s dive into ten of the biggest trending and emerging topics to watch in 2024.

1. Personalized medicine and cell therapies

Personalized medicine is a relatively new approach that aims to develop predictive, preventive, diagnostic, and therapeutic solutions more customized to each person’s physiological, environmental, and behavioral characteristics. The field has grown with the emergence of cutting-edge technologies enabling researchers to uncover individual differences in disease processes, such as DNA sequencing, multi-omics, 3D tumoroid culture systems , and wireless health monitoring.

Autologous cell therapy, which involves using a patient’s engineered cells as medicine, is major evidence of personalized medicine’s research, clinical, and commercial success. Capable of treating many intractable cancers, including multiple myeloma, cell therapy has rapidly risen in the pharmaceutical market and regulatory pipeline in the last decade. Five CAR-T cell therapies have received five FDA approval since its first in 2017. Many in the space are exploring emerging methods like NK cell and allogeneic therapies, while others explore closed, modular manufacturing systems for scale-up of existing therapies. The global cell therapy market was valued at $4.74 billion in 2023 and is expected to reach $5.89 billion in 2024.

Read more about emerging cell therapies like CAR-NK therapy

2. gene therapies.

Gene therapy , a ground-breaking field of molecular medicine predicted to impact healthcare profoundly, is seeing a renaissance after a rocky start 20 years ago. This is thanks to advances in genetics and bioengineering like CRISPR-Cas9 editing, nanoparticle biological delivery systems, and highly efficient adeno-associated virus (AAV) vector technologies.

Though applications are currently limited to research, gene therapies hold immense potential for treating diseases caused by autosomal recessive disorders such as sickle cell anemia, acquired genetic diseases such as cancer and cardiovascular diseases, and viral infections such as AIDS.

This rapidly evolving field has produced remarkable breakthroughs in recent times, with the latest being treating children with deafness caused by a mutated otoferlin gene with AAV1-hOTOF gene therapy. In 2023 , the FDA approved the first cell-based gene therapies for treating sickle cell disease and severe hemophilia A.

Explore gene therapy development solutions

3. lab sustainability.

The life sciences industry continues to have a substantial environmental impact due to its heavy use of energy and resources. The pharmaceutical industry , in particular, is responsible for 4.4% of global emissions, and unaddressed, its carbon footprint is projected to triple by 2050. As advocates for a better world through science, researchers are often also passionate about mitigating climate change and its far-reaching impact s on human and ecosystem health. Where possible, they’re seeking to limit hazardous, consumable, and packaging waste; improve energy efficiency in the lab; and extend the life cycle of their tools before disposal or recycling.

In response, research organizations and industry members like Thermo Fisher Scientific are prioritizing scientific innovaiton and creating labeling systems to help scientists understand a product’s sustainability profile more transparently. Modern sustainable design approaches are paying off with more environmentally sustainable products , such as DynaGreen™ Protein A Magnetic Bead s, that can reduce environmental impact without sacrificing scientific quality.

Read more about sustainable scientific product design

4. de-extinction science and paleogenomics.

A few decades ago, the idea of assembling a genome with or otherwise extracting meaningful genetic information from samples like 19 th century museum specimens, Egyptian mummies, and prehistoric bones seemed like science fiction – as did concepts like “de-extinction” that would seek to bring long-gone species back to life for ecological purposes. For context, even in modern forensic science applications, bone samples of even 20 years old are some of the most difficult for reliable DNA analysis.

Scientists like Svante Pääbo, 2022 Nobel Laureate in Medicine or Physiology recognized for his pioneering work in sequencing the Neanderthal genome, and the arrival of next-generation sequencing (NGS) technologies has brought these once far-fetched ideas into exciting reality.

Today’s scientific instruments and technologies make it possible to prepare, purify, and analyze more delicate and degraded samples than ever before. Research teams have already sequenced and published the genomes of at least 8,000 ancient individuals . As the field continues to grow, so do the prospects of shedding new light on our evolutionary history, genetic factors for disease risk, and more.

Read more about advancements in ancient DNA sample analysis 

5. more complex, biologically relevant cancer research models with tumoroid culture.

More than 90% of potential anti-cancer drugs fail in clinical trials, often due to the heavy limitations of 2D pre-clinical models that rely on traditional immortal tumor lines. These models struggle to accurately replicate the complex environment and biological processes within real-life patient tumors, limiting their clinical translatability. 3D culture tumoroid models , on the other hand, are emerging as excellent alternatives that can more accurately reflect the physiological behaviors and characteristics of cancer cells, closing the gap between laboratory and clinical settings.

Tumoroids , also called tumor organoids or tumor-like organoids, are complex 3D culture models sourced from primary tumors obtained from patients. Tumoroid setups have been DIY for some time, with a steep learning curve and spotty reproducibility. But newer tools like the Gibco™ OncoPro™ Tumoroid Culture Medium Kit are making tumoroid systems more accessible and standardized between research groups. These biologically relevant cancer research models have big potential to accelerate strides in cancer drug development and personalized medicine.

Read more about advances in tumoroid culture systems

6. mrna-based therapeutics.

After decades of research, mRNA-based therapeutics came into the spotlight with the launch of mRNA-based SARS-CoV-19 vaccines and have proven themselves as a safe, easy-to-produce, targeted, versatile, and effective drug class.  mRNA-based therapy also shows promise in treating diseases currently difficult to treat, such as metabolic genetic diseases, cardiovascular diseases, infectious diseases, cerebrovascular diseases, and cancer.

The emergence of commercially successful mRNA-based therapies is expected to pave the way for a new generation of nucleic acid medicines.

Read more about mRNA therapeutic research and manufacturing

7. lab automation.

Lab automation can improve the quality and reproducibility of results, support clinical translation in a closed-system environment, and improve researcher efficiency, speed, and productivity. New, exciting options are emerging fast – offering everything from GMP compliance to AI-powered analysis and all-in-one, hands-off workflow completion. Likewise, the benchtop footprint of advanced instruments are shrinking as materials and engineering technologies advance.

Automated tools and systems will be key to the clinical manufacturing future, expanding the field’s ability to both “fail fast” in R&D for processes like drug candidate screening and to scale up quickly on what works – potentially breaking the bottleneck for lifesaving therapies like mRNA vaccines, cell therapies, and more.

Learn more about lab automation and closed, modular cell therapy manufacturing technologies

8. science entrepreneurship.

The commercialization of scientific research enables researchers to move their findings into innovative products and services with potential to transform public health. Though pharmaceutical funding significantly dropped in 2023 compared to previous years, it was still a strong year for the industry . As competition for innovation strengthens, experts predict expansive deal-making in sectors with substantial increases in innovation.

Fortunately, the government and private investors are increasingly interested in supporting scientific research and commercializing innovative products and technologies, creating an ecosystem that promotes entrepreneurship in the life sciences industry.

Read about how biotech incubator BioLabs Pegasus Park in Dallas is jumpstarting innovation

9. ai-powered data analysis.

The AI revolution is changing our relationship with the world around us. The increasingly data-rich life sciences industry is a strong beneficiary. The AI in life science analytics market size was valued at $1.5 billion in 2022 and is predicted to reach $3.6 billion by 2030.

Predominantly impacting biomedicine and healthcare, AI-powered data analysis is enabling scientists and clinicians to analyze vast and complex data sets quickly and accurately. As the adoption of AI-powered data analysis increases in drug development, clinical trials, manufacturing, and basic research, the life science industry is set to experience unprecedented growth in many of its subsectors, especially precision medicine .

Read about how AI-powered image analysis is transforming flow cytometry

10. multi-omics.

Powered by advances in high-throughput technologies and informatics tools , multi-omics is deepening our understanding of human health and disease and, in turn, driving significant breakthroughs in biomedical research.

By integrating distinct information about the biological system from omics, including genomics, epigenomics, transcriptomics, proteomics, and metabolomics, multi-omics provides researchers with a comprehensive view and analysis of complex biological processes that help them more precisely classify diseases, identify biomarkers of health and disease, and discover new drug targets.

As a relatively new computational approach, multi-omics technologies have predominantly existed as research tools. Their evolution into clinical applications shows the potential to drive personalized disease prevention, diagnosis, and treatment.

Learn more about multiomics research approaches and hear from researchers exploring the space in the “Speaking of Mol Bio” podcast

Want to read more stories like this  subscribe to connect to science , your portal for life science news..

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Home | Research Topics

Top 100 Science Laboratory Technology Research Topics in 2024

• Analysis of heavy metal contamination in water sources within urban areas.
• Development of a low-cost water purification system for rural communities.
• Identification and characterization of antibiotic-resistant bacteria in hospital environments.
• Evaluation of the antimicrobial properties of natural plant extracts.
• Assessment of air quality in industrial areas using air pollution monitoring techniques.
• Analysis of soil fertility and nutrient levels in agricultural fields.
• Investigation of the effectiveness of different insecticides on pest control in crops.
• Development of a rapid diagnostic test for infectious diseases.
• Characterization of nanoparticles for drug delivery applications.
• Study of the impact of climate change on biodiversity in a specific region.
• Identification and analysis of microplastics in water bodies.
• Evaluation of the quality and safety of processed food products.
• Development of a biosensor for detecting environmental pollutants.
• Investigation of the microbial load in hospital settings.
• Analysis of heavy metal accumulation in edible crops grown near industrial areas.
• Assessment of the nutritional content of commonly consumed foods.
• Study of the effects of different cooking methods on nutrient retention in vegetables.
• Development of a bioinformatics tool for analyzing DNA sequences.
• Investigation of the genetic basis of a specific disease.
• Analysis of the pharmacological properties of medicinal plants.
• Evaluation of the effectiveness of different wound healing agents.
• Study of the impact of electromagnetic radiation on human health.
• Analysis of waterborne pathogens in recreational water sources.
• Development of a biodegradable packaging material.
• Assessment of the microbial quality of cosmetics and personal care products.
• Identification and quantification of allergens in food products.
• Study of the microbial diversity in extreme environments.
• Evaluation of the effectiveness of various disinfection methods in healthcare settings.
• Analysis of the nutritional composition of alternative protein sources.
• Development of a sensor for detecting foodborne pathogens.
• Investigation of the impact of pesticides on non-target organisms in agriculture.
• Characterization of nanomaterials for environmental remediation.
• Study of the role of enzymes in industrial processes.
• Analysis of the quality of drinking water in rural communities.
• Evaluation of the microbial contamination of cosmetics during use.
• Development of a diagnostic tool for detecting genetic disorders.
• Investigation of the effectiveness of herbal remedies in treating common ailments.
• Analysis of the microbiome in the human gut.
• Study of the impact of noise pollution on human health.
• Assessment of the nutritional status of vulnerable populations.
• Development of a rapid test for detecting foodborne pathogens.
• Evaluation of the antimicrobial properties of essential oils.
• Analysis of the presence of pharmaceutical residues in water sources.
• Investigation of the effects of environmental pollutants on aquatic ecosystems.
• Characterization of bioactive compounds in medicinal plants.
• Study of the microbial communities in different soil types.
• Assessment of the quality of drinking water from different sources.
• Development of a diagnostic tool for detecting drug-resistant bacteria.
• Analysis of the impact of urbanization on biodiversity.
• Evaluation of the effectiveness of different water treatment methods.
• Investigation of the genetic diversity of a specific plant species.
• Characterization of nanomaterials for drug delivery applications.
• Study of the effects of pollution on fish health in aquatic ecosystems.
• Analysis of the nutritional content of organic vs. conventionally grown produce.
• Development of a biosensor for detecting foodborne pathogens.
• Assessment of the microbial quality of recreational water sources.
• Investigation of the role of probiotics in promoting gut health.
• Evaluation of the effectiveness of different cleaning agents in healthcare settings.
• Analysis of heavy metal levels in hair samples as a biomarker of exposure.
• Study of the impact of agricultural practices on soil health.
• Identification and quantification of bioactive compounds in herbal teas.
• Development of a rapid diagnostic test for cancer biomarkers.
• Assessment of the microbial contamination of public transportation surfaces.
• Analysis of the nutritional composition of traditional vs. modern diets.
• Investigation of the antimicrobial properties of marine-derived compounds.
• Characterization of nanoparticles for cancer therapy.
• Study of the impact of air pollution on respiratory health.
• Evaluation of the effectiveness of different wound dressings in promoting healing.
• Analysis of the microbial diversity in fermented foods.
• Development of a diagnostic tool for detecting food allergies.
• Investigation of the effects of climate change on plant phenology.
• Assessment of the quality of herbal supplements in the market.
• Study of the microbial communities in wastewater treatment plants.
• Identification and characterization of antibiotic-resistant strains in farm animals.
• Analysis of the nutritional content of school lunch programs.
• Evaluation of the microbial contamination of cosmetics during manufacturing.
• Investigation of the effects of electromagnetic fields on cell cultures.
• Characterization of nanomaterials for use in medical imaging.
• Study of the impact of land use change on ecosystem services.
• Assessment of the microbial quality of fresh and processed seafood.
• Analysis of heavy metal levels in hair samples of industrial workers.
• Evaluation of the effectiveness of different water filtration systems.
• Investigation of the genetic basis of a specific plant disease.
• Development of a rapid diagnostic test for viral infections.
• Study of the antimicrobial properties of honey against clinical isolates.
• Identification and quantification of pollutants in urban air.
• Analysis of the nutritional content of gluten-free products.
• Assessment of the microbial contamination of indoor air in residential buildings.
• Investigation of the effects of pharmaceuticals on aquatic organisms.
• Characterization of nanoparticles for use in targeted drug delivery.
• Study of the impact of noise pollution on wildlife.
• Evaluation of the effectiveness of different mosquito control methods.
• Analysis of heavy metal levels in agricultural soils.
• Investigation of the genetic diversity of a specific animal species.
• Assessment of the microbial quality of street food in urban areas.
• Identification and characterization of bioactive compounds in marine organisms.
• Development of a rapid diagnostic test for foodborne pathogens.
• Study of the antimicrobial properties of traditional fermented foods.
• Analysis of the nutritional content of school breakfast programs.
• Evaluation of the microbial contamination of pharmaceutical products.
• Investigation of the effects of climate change on insect populations.
• Characterization of nanomaterials for use in environmental sensors.
• Development of a biosensor for detecting waterborne pathogens.
• Study of the impact of light pollution on nocturnal animals.
• Assessment of the microbial quality of raw and pasteurized milk.
• Analysis of heavy metal levels in seafood products.
• Evaluation of the effectiveness of different hand sanitizers.
• Investigation of the genetic basis of a specific animal behavior.
• Identification and quantification of allergens in pet food.
• Development of a rapid diagnostic test for food allergies.
• Study of the antimicrobial properties of herbal extracts against oral pathogens.
• Analysis of the nutritional content of plant-based meat substitutes.
• Assessment of the microbial contamination of public swimming pools.
• Investigation of the effects of air pollution on plant physiology.
• Characterization of nanoparticles for use in solar cells.
• Development of a biosensor for detecting pesticide residues in fruits and vegetables.
• Study of the impact of water pollution on fish behavior.
• Evaluation of the microbial quality of water in recreational areas.
• Analysis of heavy metal levels in hair samples of hairdressing salon workers.
• Investigation of the genetic diversity of a specific bird species.
• Identification and quantification of antimicrobial compounds in honey.
• Development of a rapid diagnostic test for fungal infections.
• Study of the antimicrobial properties of probiotic bacteria.
• Assessment of the microbial contamination of food contact surfaces in restaurants.
• Analysis of the nutritional content of gluten-free and lactose-free products.
• Evaluation of the effectiveness of different laundry detergents in removing bacteria.
• Investigation of the impact of urbanization on bird populations.
• Characterization of nanomaterials for use in water treatment.
• Development of a biosensor for detecting foodborne viruses.
• Study of the antimicrobial properties of essential oils against foodborne pathogens.
• Analysis of heavy metal levels in urban dust.
• Assessment of the microbial quality of cosmetics during storage.
• Investigation of the genetic diversity of a specific reptile species.
• Identification and quantification of contaminants in seafood products.
• Development of a rapid diagnostic test for respiratory infections.
• Study of the antimicrobial properties of plant-derived compounds.
• Evaluation of the effectiveness of different surface disinfectants in healthcare settings.
• Analysis of the nutritional content of plant-based dairy alternatives.
• Assessment of the microbial contamination of public transportation vehicles.
• Investigation of the effects of climate change on amphibian populations.
• Characterization of nanoparticles for use in drug delivery to the brain.
• Development of a biosensor for detecting antibiotic residues in meat products.
• Study of the impact of light pollution on plant growth.
• Evaluation of the microbial quality of fresh and processed fruit juices.
• Analysis of heavy metal levels in urban gardening soils.
• Investigation of the genetic diversity of a specific fish species.
• Identification and quantification of contaminants in honey.
• Development of a rapid diagnostic test for foodborne parasites.
• Study of the antimicrobial properties of silver nanoparticles.
• Assessment of the microbial contamination of public restroom surfaces.
• Analysis of the nutritional content of gluten-free and vegan products.
• Evaluation of the effectiveness of different handwashing techniques.
• Investigation of the impact of urbanization on butterfly populations.
• Characterization of nanomaterials for use in cancer therapy.
• Development of a biosensor for detecting waterborne viruses.
• Study of the antimicrobial properties of herbal extracts against skin pathogens.
• Analysis of heavy metal levels in urban rivers.
• Assessment of the microbial quality of fresh and processed vegetables.
• Investigation of the genetic diversity of a specific insect species.
• Identification and quantification of contaminants in herbal supplements.
• Development of a rapid diagnostic test for foodborne toxins.
• Study of the impact of noise pollution on fish behavior.
• Evaluation of the effectiveness of different waste management practices.
• Analysis of the nutritional content of plant-based protein supplements.
• Assessment of the microbial contamination of public park surfaces.
• Investigation of the effects of climate change on bird migration patterns.
• Characterization of nanoparticles for use in sunscreen products.
• Development of a biosensor for detecting antibiotic-resistant bacteria in water.
• Study of the antimicrobial properties of essential oils against respiratory pathogens.
• Analysis of heavy metal levels in urban street dust.
• Evaluation of the microbial quality of fresh and processed meat products.
• Investigation of the genetic diversity of a specific spider species.
• Identification and quantification of contaminants in pet toys.
• Development of a rapid diagnostic test for foodborne viruses.
• Study of the impact of light pollution on bat behavior.
• Assessment of the nutritional content of plant-based baby foods.
• Analysis of the microbial contamination of public playground equipment.
• Evaluation of the effectiveness of different hand sanitizers against viruses.
• Investigation of the effects of climate change on bee populations.
• Characterization of nanomaterials for use in water filtration systems.
• Development of a biosensor for detecting foodborne toxins in seafood.
• Study of the antimicrobial properties of copper nanoparticles.
• Analysis of heavy metal levels in urban garden vegetables.
• Assessment of the microbial quality of fresh and processed dairy products.
• Investigation of the genetic diversity of a specific fungi species.
• Identification and quantification of contaminants in pet bedding.

View Downloadable Project Topics and Materials

Home » Blog » List of Interesting Medical Laboratory Sciences Project Topics & Ideas for Beginners

List of Interesting Medical Laboratory Sciences Project Topics & Ideas for Beginners

Medical laboratory sciences project topics & ideas.

Medical Laboratory Sciences — We have developed a compelling list of interesting Medical Laboratory Sciences research project topics. These topics, when adequately executed, are guaranteed to get you a good grade in your final year project.

1. Assessment of Staphylococcal Nosocomial Infections in National Orthopaedic Hospital, Enugu.

2. Prevalence of Hepatitis C Virus Infection in Diabetic Subjects at Enugu State University of Science and Technology Teaching Hospital, Parklane, Enugu.

3. Serum Levels of Proinflammatory Cytokines, Haptoglobin in Children of Various Abo Blood Group And Heamoglobin-Genotype With P. Falciparaum Malaria in Nnewi, Nigeria.

4. Assessment of Tinea Infections Among Primary School Children in Aninri Local Government Area of Enugu State, Nigeria.

5. Molecular Basis of Immunological Dysfunction In People Living With Hiv and Aids in Enugu, Nigeria.

6. Assessment of Biochemical Markers of Iron And Some Haematological Parameters on Blood Donors in Enugu State.

7. Morphological Effect of Crude Extract of Viscum Album Linnaeus on Some Selected Visceral Organs of Albino Rat.

8. Molecular Characterization of Exon 28 of the Vwf Gene In Nigerian Population.

9. Assessment of Staphylococcal Nosocomial Infections in National Orthopaedic Hospital, Enugu.

10. Haemostatic and Haematological Studies of Aqueous Extract of Bidens Pilosa in Wistar Rats.

11. Investigations of Haematopoietic Activities of Sesamum Indicum, Linn Lectin in Albino Wistar Rats.

12. Serum Fibronectin Levels in People Living With HIV/AIDs.

13. The Effect of Ocimum Tenuiflorum (Nchuanwu) Leaf Extract on Hematolgical Parameters of Immumnosuppressed Albino Rats.

14. Haemopoietic and Haematinic Property of the Leaf and Fruit Extract of Solanum Nigrum L (Spp Villosum) in Anaemic Albino Wistar Rats.

15. Potential for the Prediction of Prostate Cancer Risk Using Haplotypes of Exon1 of Klk2 Gene.

16. Detection of BCR-ABL1 Fusion Gene in Saliva of Chronic Myeloid Leukaemic Patients.

17. Coagulation Profile of Non-Diabetic Hypertensive Patients in Enugu Urban Enugu State.

18. Serum Gamma-Glutamyl Transferase, Total Antioxidant Concentration and Histological Changes in Liver, Kidney and Heart of Alloxan-Induced Diabetic Rats.

19. ABH Prevalence, CD4 and CD8 Levels in Secretors and Non-Secretors of ABH Antigens Among HIV Positive Individuals in Abakaliki Area of South-East Nigeria.

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Six Adapters for Crewed Artemis Flights Tested, Built at NASA Marshall

Former Astronaut Charles M. Duke, Jr.

Alphabet Soup: NASA’s GOLD Finds Surprising C, X Shapes in Atmosphere

The 1998 Florida Firestorm and NASA’s Kennedy Space Center

Climate Interactives

NASA’s Mars Odyssey Captures Huge Volcano, Nears 100,000 Orbits

Detective work enables perseverance team to revive sherloc instrument.

Pillars of Creation Star in New Visualization from NASA’s Hubble and Webb Telescopes

Mapping the Red Planet with the Power of Open Science

Surprising Phosphate Finding in NASA’s OSIRIS-REx Asteroid Sample

NASA Prepares for Air Taxi Passenger Comfort Studies

Hypersonic Technology Project

NASA Engineer Honored as Girl Scouts ‘Woman of Distinction’

Amendment 22: Heliophysics Flight Opportunities in Research and Technology Final Text and Due Date

Augmented Reality Speeds Spacecraft Construction at NASA Goddard

Slow Your Student’s ‘Summer Slide’ and Beat Boredom With NASA STEM

NASA Webb, Hubble Scientist Marcia Rieke Awarded Gruber Cosmology Prize

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Astronauta de la NASA Frank Rubio

Diez maneras en que los estudiantes pueden prepararse para ser astronautas

Astronauta de la NASA Marcos Berríos

Hypersonic research topics.

Shannon Eichorn

System-level design and analysis, propulsion technologies, vehicle technologies, high temperature materials.

The Hypersonic Technology project is divided into four research topic areas. The first research topic is system-level design, analysis, and validation, which explores the impacts of technologies on vehicle performance. The second and third topics focus more specifically on propulsion technologies and vehicle technologies enabling hypersonic flight. The fourth topic area explores material technology that can survive and be reused in high-temperature hypersonic flight.

The System-Level Design, Analysis, and Validation research topic (RT-1) investments are focused on computational tool development and validation for hypersonic propulsion and vehicle system analysis methods including uncertainty quantification. RT-1 coordinates and performs definitive systems analysis studies to clarify the potential benefits of hypersonic vehicles and technologies for both high-speed civilian travel and space access and will use these studies to drive a technology portfolio focused on reusability, affordability, and reliability.

The Propulsion Technologies research topic (RT-2) focuses on turboramjet, ramjet, integrated combined-cycle, dual-mode, and scramjet propulsion systems and associated propulsive mode transitions, combustor operability, fuels, controls, and sensors. RT-2 develops computational fluid dynamic technologies to enable predictive simulations of these systems.

The Vehicle Technologies research topic (RT-3) investments focus on understanding aerodynamic and aerothermodynamic phenomena, such as high-speed boundary-layer transition and shock-dominated flows, to further technologies that improve aerodynamic performance as well as reduce aerodynamic heating.

The High Temperature Durable Materials research topic (RT-4) investments focus on advanced propulsion and vehicle materials research. Due to the operating conditions of hypersonic vehicles, most of the structures and materials are shared between propulsion and vehicle components, which include aeroshell, control surface, leading edge, propulsion, and sealing concepts. RT-4 examines the design and evaluation of potential structure and material concepts through component development and testing under relevant environments. In addition, because of the extreme environments the materials and structures must endure, RT-4 also includes development of advanced thermal and structural measurement methods.

About the Author

Shannon Eichorn is the Strategic Engagement Lead for NASA’s Advanced Air Vehicles Program. She is a former test engineer in supersonic wind tunnels and former engineer managing facilities, such as the Aeroacoustic Propulsion Lab, Glenn Extreme Environments Rig, and Creek Road Cryogenics Complex.

Explore More

NASA Launches Rocket to Study Hypersonic Aircraft

AETC Hypersonic Facilities

Rocket Launch Scheduled March 21 from NASA’s Wallops Flight Facility

Discover related topics.

Small Business Innovation Research (SBIR) / Small Business Technology Transfer (STTR)

Related Terms

• Hypersonic Technology
• Advanced Air Vehicles Program

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FUNAAB Post UTME Past Questions - Federal University of Agriculture,…

UNIBEN Post UTME Past Questions - University of Benin

UNICAL Post UTME Past Questions - University of Calabar

UNILAG Post UTME Past Questions - University of Lagos

Project / Seminar Topics under Science Laboratory Technology

In quest of Science Laboratory Technology project or seminar topics , this platform is intended for (2024) Undergraduate and Postgraduate Students in Nigeria and Other Countries, who are searching for research proposal topics with Materials in PDF or Microsoft Word (Docx) that will serve as a roadmap for achieving their final year research aim in Science Laboratory Technology (SLT).

• Select and document the research topics from our list of Science Laboratory Technology seminar topics that interests you and aligns with your academic background and career goals;
• Review the synopsis of the complete research material of your selected topics and write a proposal;
• Present your seminar research topics to your academic supervisor for assessment and approval; and
• Finally, inform Us with the phone number below after the topic has been approved to obtain the complete research material (Chapters 1–5) including references.

See also – Subject Based Seminar Related Topics

The sole purpose of this platform is to provide simple and swift methods to find top-notch (2024) scholaristic research topics and materials on Science Laboratory Technology (SLT). The PDF (Microsoft Word) project materials for Science Laboratory Technology seminar topics that can potentially be chosen for proposal write-up submission are listed below.

100+ List of Available Science Laboratory Technology Project or Seminar Topics

Evaluation and Optimization of the Physiochemical Properties of Composite Flours

In Vitro Antidiabetes Screening of Stecuria Satigera Steam Back of Crude and Chromatography Fractions

Production of homemade carrot oil and its benefits

Determination, Organic Matter, Total Nitrogen and Elemental Content of Cow Dung

Determination of Caffeine Content in Energy Drinks

Laboratory Production of Ethanol From Millet

Science Laboratory Technology Seminar Topics

Extraction and Characterization of Orange Seed and Pawpaw Seed Oil

Determination of Heavy Metal in Fresh Water Fish

Extraction and Characterization of Orange Seed, African Pear and Pawpaw Seed Oil

Mineral Composition and Sensory Acceptability of Cookies Produced from Cassava Pro Vitamin a Wheat Flour Blend

Stool Analysis for Parasitic Worms (Enteric Worm) Among Primary School Pupils

Antimicrobial Activities of Garlic and Ginger Extracts

Extraction of Margarine From Palm Kernel, Coconut, and Melon Oil Blends

Science Laboratory Technology Seminar Topics on Bacteria

Estimation of Mineral Contents of Mango Fruits

Production of Bioethanol from Millet Hust

Design and Construction of a Metre Bridge

Nutritional Quality of Jam Produced from Blends of Banana, Pineapple and Watermelon Pulp

The Design and Fabrication of a Electrical Centrifuge

Determination of Enzymes Presence in Starch Processing From Maize

Science Laboratory Technology Seminar Topics on Fruit Spoilage

Sugar Content Analysis Per 10ml of Liquid Fayrouz, Coca Cola, Guinness Malt, Amstel Malt, and Pepsi Drink

Aflatoxin in Nutrition

Production of Mosquitoes Repellent Insecticide

Effect of Temperature on the Growth of Yeast

Bacteriological Examination of Fried Snail

Production of Comparative Analysis of Different Drying Methods on the Quality of Akpu Flour

Comparative Study of Antibacterial Activity of Three Selected Soap (Septol, Detol and Tetmasol)

Microbial Examination of Spoilt Avocado Fruit

Effectiveness of Antiseptics Against Pathogens

The Production and Analysis of Pesticide - Insecticide

ANTISEPTICS

Examining the Presence and Concentration of Some Phytochemicals in Avocado Pear (Persea Americana Mill) Seed

Water Analysis on Covered and Open Well

Production of Juice From Pineapple and Watermelon

Production of Wine From Banana and Sweet Orange

Investigation of Heavy Metals Contamination of Nigerian Fruit Juice

Science Laboratory Technology Seminar Topics on Ecology

An Epidemiologic Survey for Schistosomiasis Among Pupils in Amagunze Community

Extraction and Analysis of Alkaloids in Carica Papaya Leaves

Bacteriology in Ice Cream

Formulation and Evaluation of Some Healthy Natural Juice Blends

Evaluation of Bread and Cake from Composite Flour of White Wheat, Adu and Beltroth

Production of Body Lotion Using Cocoa Extract

Formulation of Microbial Growth Medium From Sweet Potato

The Nutritional Composition of Plant Milk (Soya Bean)

Review on Phytochemicals and Medicinal Properties of Watermelon Seed

Comparative Determination of Protein Contents of Breadfruit, Brown Beans and Soybeans

Getting more topics...

Seminar Guideline for Science Laboratory Technology

Science Laboratory Technology Seminar research has shown that it is important to be aware that the research write-up for seminar topics on Science Laboratory Technology is limited to 20 pages, including some sections from the fully obtained research material (Chapters 1–5) and References. When writing up your seminar research, remember to utilize the future tense rather than the past. Students studying Science Laboratory Technology can use the sections listed below to assist them with their seminar research projects.

Introduction of Science Laboratory Technology Seminar Topics

Statement of Problems

Motivation of Research (Optional)

Purpose (Aim and Objectives) of Study

Significance (Justification) of Study

Review of three (3) or more related literature

Research Methodology

Ethical Consideration (Optional)

Presentation and Data Analysis (Summary)

Recommendation of Selected Topic (Optional)

Subject Based Seminar Topics and Research Questions

Can i get simple current solar energy research seminar topic.

We successfully found a topic related to your query, which is captioned “ Solar Technology: An Alternative Source of Energy for National Development ” – This research was carried out to understand solar technology: An alternative source of energy for national development. The study was based on the pursuance of basic objectives to ascertain the present state of power generation and supply in Nigeria, to examine the possibility of reviving the energy sector of Nigeria, highlight the advantages of solar technology as it affects national development. In essence the study sets out to contribute to the advancement of knowledge on solar energy in Nigeria as an alternative power supply for national development. The quantitative research technique was utilized during the course of the study. The …

How can I get one of the best related seminar topics on Growth of Small and Medium Scale Business ?

Our research bot has sourced out one of the best related seminar topic titled “ The Impact of Microfinance Bank in Growth of Small and Medium Scale Business in Nigeria ” – This study discusses the impact of Microfinance Institution (Microfinance bank) on the growth of Small and Medium Scale Enterprises (Small and medium scale business) in the Owerri Urban. The study examined the detailed profile of Small and medium scale business in the Owerri Urban of Nigeria, the contribution of Microfinance bank to entrepreneurial growth, the challenges encountered by Small and medium scale business in accessing credit and the rate of credit utilization by Small and medium scale business. An analysis of the profile of Small and medium scale business shows that most Small and medium scale business area their Micro …

How Can I Find Seminar Topics Related to Investment Decision ?

Final year students searching for seminar related topics on Investment Decision should refer to this topic “ Financial Reporting Quality and Its Effect on Investment Decision ” – Financial reporting quality entails the standardization of preparation and presentation of both financial and non-financial information by the financial institution for effective planning and reliable decisions. The study scrutinizes the Financial Reporting Quality and Its Effect on Investment Decision. In achieving this aim, the following specific objectives were laid out to know whether the information in the financial reports of companies and other financial information areas are understood and used for investment decision making ascertain the extent the company’s concept, convention and principles are capable of meeting users / investors needs, and ascertain the extent published financial statement induced more …

Searching for a Specific Final Year Seminar Topics on Change Management ?

Among the most important seminar topics related to Change Management, we found “ Management of Foreign Exchange in Nigeria by CBN ” – This thesis deals with foreign exchange management in Nigeria by the Central Bank of Nigeria (CBN) from 1959 to July 2004. The need to manage foreign exchange became imperative as a result of dis equilibrium in the foreign exchange market caused by inadequate supply of foreign exchange management is a conscious attempt to harnesses foreign exchange resources deploy them to service the economy so as to prevent the economy from experiencing shocks due to foreign exchange volatility. The central focus of thesis is to examine how CBN through its policy measures manages foreign exchange in the country. To carryout this thesis, …

How Can I Locate Product Planning Related Seminar Topics and Student Material?

After searching our library, we discovered that Product Planning has one of the best related seminar topics titled “ Determinants to Family Planning Choices among Women of Reproductive Age ” – Family planning is the process of controlling the number of children wanted in a marriage using contraceptive method, often known as birth control measure. The aim of the study is to determine the Family Planning Choices among Women of Reproductive Age. In achieving this aim, the following specific objectives were laid out to examine the role of male in family planning, find out reasons poor application of contraceptive (family planning) method in the area of study, and Proffer solution or recommendation that will further improve on the existing use of contraceptive method and to further open the eyes of the …

Other Science Laboratory Technology Based Related Topics

Science Laboratory Technology Related Departmental Repository assistance in finding your preferred topic for proposal submission or presentation purpose. Below is the list of related repository under Science Laboratory Technology department:

Crop Science Seminar Topics

Library and Information Science Seminar Topics

Political Science Seminar Topics

Soil Science Seminar Topics

Science Laboratory Technology Topics Page Content

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Scientist Spotlight: Teaching Technical Topics to High Schools

Jun 27, 2024 —.

David Peeler with Leigh McCook, director of STEM@GTRI

David Peeler , a research scientist with the Institute for People and Technology (IPaT) at Georgia Tech, dedicates his time to supporting high teachers and students across the state of Georgia by teaching computer programming-related topics.

Peeler is a key team member supporting Georgia Tech’s Rural Computer Science Initiative launched in 2022. This initiative offers co-teaching lessons prepared by Georgia Tech faculty and offers virtual classes in computer science to expose Georgia high school students to a variety of technical topics and career pathways.

The program was conceived by Georgia Tech’s Center for Education Integrating Science, Mathematics and Computing (CEISMC) ) and the Georgia Tech Research Institute, specifically STEM@GTRI , to create and launch a pilot program for rural Georgia school districts with support from Georgia’s legislators to bring technical knowledge directly into high school classrooms.

“I’ve created and taught Java professional development courses for high school teachers to learn and use in their classes,” said Peeler. “Part of my job is to be on call for instructors who need me to troubleshoot problems. In addition, we typically have a week of in-class instruction where I virtually beam into the class to teach directly, then we introduce a project for them to try and tackle on their own based from the in-class material that we taught. I really like what I’m doing for Georgia high schools.”

Peeler has also created an instructional module introducing students to robotic programming. Students develop and deploy code using the MakeCode environment which is an online platform and toolset developed by Microsoft that enables users, especially beginners and students, to learn programming and computer science concepts through blocked-based coding.

Through this initiative and with the help of Peeler, Georgia Tech is empowering the next generation of tech-savvy leaders fostering interest in STEM fields and opening doors to exciting career opportunities.

“I'm extremely proud to be a part of this initiative and kickstarting the next generation of high school students in the computer science realm,” said Peeler.

Walter Rich

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June 26, 2024

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New tool enables faster, more cost-effective genome editing of traits to improve agriculture sustainability

by Donald Danforth Plant Science Center

With the goal of reducing the time and cost it takes to bring an improved crop to the marketplace to improve agriculture sustainability, research conducted in the laboratory of Keith Slotkin, Ph.D., and his colleagues in the Plant Transformation Facility at the Donald Danforth Plant Science Center, was recently published in the journal Nature . The publication " Transposase-assisted target site integration for efficient plant genome engineering " focuses on technology called TATSI (Transposase-Assisted Target Site Integration), which uses transposable elements to integrate custom DNA into specific sites in plant genomes.

The TATSI technology takes advantage of over two billion years of evolution of plant transposable elements , which naturally function as honed molecular machines to insert DNA into the genome . The high-frequency and high-precision target site integration of custom DNA into plant genomes enables the faster and less expensive production of gene-edited plants to address global challenges in agriculture, climate and the environment.

A critical bottleneck in modern crop improvement is the low frequency and error-prone integration of foreign DNA into the plant genome, hampering genome editing approaches for crop improvement. The CRISPR/Cas system functions like a pair of molecular "scissors" to cut the genome and introduce site-specific changes to the DNA. But current methods lack robust ways to add custom DNA accurately and efficiently at those edited sites.

TATSI technology takes advantage of the molecular "glue" feature of transposable elements to provide custom "cut-and-paste" genome editing when combined with CRISPR/Cas. The "scissors + glue" combination enables an order-of-magnitude increase in the rate of targeted DNA integration in plant genomes , allowing for custom improvement of plants through the addition of important traits such as virus resistance, elevated nutrient levels, or better oil composition.

The research on TATSI started in 2019 following the Danforth Center's "Conversations: Big Ideas 2.0" event, a competition in which a team from the Slotkin proposed harnessing the power of transposable elements for crop improvement. Often referred to as the "junk DNA," transposable elements comprise over 70% of corn genome.

Using the enzyme called "transposase" encoded by certain transposable elements, the big idea was a new genome editing tool that could enable development of a wide variety of new traits fast, better and cheaper. The Slotkin team won the competition and received seed money to initiate their research.

Journal information: Nature

Provided by Donald Danforth Plant Science Center

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